The Saudi initiative for asthma – 2024 update: Guidelines for the diagnosis and management of asthma in adults and children

Al-Moamary, Mohamed Saad; Alhaider, Sami A.; Allehebi, Riyad; Idrees, Majdy M.; Zeitouni, Mohammed O.; Al Ghobain, Mohammed O.; Alanazi, Abdullah F.; Al-Harbi, Adel S.; Yousef, Abdullah A.; Alorainy, Hassan S.; Al-Hajjaj, Mohamed S.

doi:10.4103/atm.atm_248_23

Cited by 4 publications

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References 514 publications

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“…As a result mast cells are activated and lymphocytes B increase the production of immunoglobulin E (IgE). 3,4 Non-type-2 phenotype is characterised by increase in neutrophil caused by release of cytokines by Th1 and Th17 cells. 4 Treatment of asthma includes inhaled corticosteroids and short-acting β2-agonists for shortterm relief.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Non-type-2 phenotype is characterised by increase in neutrophil caused by release of cytokines by Th1 and Th17 cells. 4 Treatment of asthma includes inhaled corticosteroids and short-acting β2-agonists for shortterm relief. However, compliance to corticosteroid treatment is low, it was estimated that 22% to 63% of asthmatic patients stick to regular use of corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

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Role of dietary supplements in the treatment of asthma - a narrative review

Kozicz,

Kołodziej,

Saiuk

et al. 2024

J Educ Health Sport

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Introduction: Asthma is a common inflammatory disease of airway affecting both adults and children. In a large number of cases asthma remains poorly controlled. There is a need to find an additional therapeutic demeanour alleviating symptoms and lowering the risk complications in a long-term. Recently, increasing number of studies has been examining dietary supplements in regards to their anti-inflammatory, immunomodulatory, anti-remodelling properties and their use in asthmatic patients. Aim of the Study: The aim of the study was to collect and analyse current literature regarding influence of different dietary supplements on the course of asthma in both adults and children. Methods and Materials: Extensive research was conducted using PubMed and Google Scholar, with the primary focus on literature from the past 5 years. Firstly, potential dietary supplements affecting course of asthma were collected. The names of the substances were juxtaposed with term “Asthma” to gather data regarding their effect on occurrence and control of asthma and potential mechanisms responsible for it. Additionally, references from selected articles were included in the analysis. Results: Dietary supplements show promising results in decreasing asthma symptoms and lowering inflammation of airway. However, our study revealed that in current state of knowledge there is a deficit of studies performed on humans, especially large-scale, prospective studies that assess the efficacy of different doses of dietary supplements. Thus, further research of dietary supplements in asthma is needed, especially large-scale randomised controlled trials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of dietary supplements in the treatment of asthma - a narrative review

Kozicz,

Kołodziej,

Saiuk

et al. 2024

J Educ Health Sport

View full text Add to dashboard Cite

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APPaRENT 3: Asthma Patients’ and Physicians' Perspectives on the Burden and Management of Asthma in Seven Countries

Aggarwal,

Al-Moamary,

Allehebi

et al. 2024

Adv Ther

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Introduction Asthma management is strongly dependent on physician and patient beliefs and perceptions about the disease and its long-term treatment. The APPaRENT 3 study was conducted to explore factors influencing treatment choice and to understand patients’ and physicians’ attitudes and perspectives on the use of controller inhalers in regular versus flexible dosing for asthma management. Methods This cross-sectional survey of patients with asthma and treating physicians was conducted in seven countries: Indonesia, Malaysia, Philippines, Thailand, Vietnam (patient survey only), Saudi Arabia, and the United Arab Emirates. Assessment was carried out through an online/face-to-face questionnaire, where patients’ viewpoints were focused on their attitudes and beliefs about asthma and treatment adherence, whereas physicians’ viewpoints were gathered on their attitudes and beliefs about asthma management, knowledge of and adherence to asthma treatment guidelines, and asthma treatment regimens. Results Overall, 1400 patients (mean age, 34 years) and 599 physicians (mean age, 43 years) were included in the survey. Physicians similarly prioritised symptom control (39%) and exacerbation reduction (40%) in moderate asthma, whereas patients prioritised symptom control (41%) over exacerbation reduction (22%). Although both groups (physicians, 86%; patients, 84%) perceived asthma as well-controlled, poor management was evident based on Asthma Control Test (ACT) scores (mean, 15.7; standard deviation, 4.14; 82% had an ACT score < 20) and high symptom burden (39% reported nighttime awakenings or early mornings ≥ 2 nights/week). Most patients (76%) with moderate asthma were prescribed regular dosing, with the most common treatment being inhaled corticosteroid (ICS)/long-acting β 2 -agonist (LABA) with as-needed inhaled short-acting β 2 -agonist (SABA; 20%). Among patients on maintenance and reliever therapy, 93% of patients received a separate inhaled reliever. Conclusions Despite high symptom burden, patients overestimated their level of asthma control. Physicians prioritised controlling symptoms and reducing exacerbations as treatment goals for moderate asthma, often prescribing regular dosing with ICS/LABA with as-needed inhaled SABA. Supplementary Information The online version contains supplementary material available at 10.1007/s12325-024-02900-2.

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