The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells

Beauvillain, Céline; Meloni, Francesca; Sirard, Jean‐Claude; Blanchard, Simon; Jarry, Ulrich; Scotet, Mari; Magistrelli, Giovanni; Delneste, Yves; Barnaba, Vincenzo; Jeannin, Pascale

doi:10.1016/j.jhep.2009.11.031

Cited by 38 publications

(31 citation statements)

References 38 publications

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“…It has also been the positioning of lysine in the AA sequence of the ligand binding pocket which results in high binding affinities [107]. Some SRs are capable of homo-and heterodimerization with other SRs, such as occurs in the cooperative interaction between SR-A1 and SREC-1 and between SREC-1 and SREC-11 [108,109]. In turn, the SREC-1/SREC-11 complex can cooperate with the Toll-like receptor-2 (TRL2) in the uptake and cross-presentation of antigens for T cell activation (Fig.…”

Section: Scavenger Receptor Endocytotic Pathwaysmentioning

confidence: 99%

“…2). The formation of this three-receptor cooperative complex results in enhanced endocytotic activity and receptor signaling [108]. The LOX-1 SR is also involved in antigen cross-presentation on dendritic cells serving as a dimer partner for direct binding of HSP70-bound antigen to calreticulin at the cell surface of the antigen-presenting (dendritic) cells [110] (Fig.…”

Section: Scavenger Receptor Endocytotic Pathwaysmentioning

confidence: 99%

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Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family

Mizejewski

2010

Tumor Biol.

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The identification of a receptor for alpha-fetoprotein (AFP) has long been sought in the field of medicine. The uptake and endocytosis of AFP by rat tumor cells in 1984 sparked a series of confirmatory reports and the original studies were then extended to include multiple tumor types in rats, mice, and humans. The following year, French investigators partially characterized the binding properties of the AFP receptor, but they were not able to purify the receptor. It was not until 1991-1992 that an AFP receptor was partially purified and characterized from both human monocytes and breast cancer cells. By 1993, a monoclonal antibody had been raised against the AFP receptor produced from a breast cancer extract with claims that the receptor was a widespread (universal) oncofetal biomarker for cancer. However, that receptor has yet to be cloned and/or purified due to its complex multimeric binding interactions and associations. The present report will review the literature of the multiple putative AFP receptors described to date, the cellular uptake and endocytosis of AFP, and the biochemical characterization of these putative cell-surface proteins. In addition, evidence derived from computer modeling, proteolytic degradation patterns, and amino acid sequence analysis will be presented in a proposed identification of a family of multi-ligand binding receptors; this family fits many, if not most, of the criteria required for an AFP receptor. The purposed receptor protein family is tentatively identified as the Scavenger receptors which comprise several classes of single- and double-pass integral transmembrane proteins. Present data do not support the concept that the AFP receptor is a "universal" tumor receptor and/or biomarker.

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Section: Scavenger Receptor Endocytotic Pathwaysmentioning

confidence: 99%

Section: Scavenger Receptor Endocytotic Pathwaysmentioning

confidence: 99%

Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family

Mizejewski

2010

Tumor Biol.

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“…A seminal study by Means and colleagues also demonstrated in vitro and in vivo that SCARF1 is able to mediate binding and uptake of the fungal pathogens, Cryptococcus neoformans and Candida albicans , via β-glucan, but, again, the presence of TLR2 was required to elicit macrophage activation and the initiation of a proinflammatory immune response [6]. Furthermore, it has also been shown that SCARF1 again cooperates with TLR2 to induce myeloid cell activation in response to the hepatitis C virus (HCV) protease, non-structural protein (NS)3 [26]. More recently, Murshid and colleagues have also shown that the presence of SCARF1 can augment the TLR-mediated activation of the NF-κB pathway and ultimately the release of proinflammatory cytokines, such as IL-8, IL-6, and TNFα, in cells stimulated with either the TLR3 ligand, poly I:C (dsRNA) [27], or the TLR4 ligand, lipopolysaccharide (LPS) [24].…”

Section: Functions Of Scarf1mentioning

confidence: 99%

SCARF1: a multifaceted, yet largely understudied, scavenger receptor

Patten

2018

Inflamm. Res.

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BackgroundAs is a prerequisite of belonging to the scavenger receptor super family, SCARF1 (scavenger receptor class F, member 1) is known to play a key role in the binding and endocytosis of a wide range of endogenous and exogenous ligands.FindingsUnlike most scavenger receptors, SCARF1 is an essential protein, as SCARF1-deficient mice exhibit a severe resting phenotype in which they develop systemic lupus erythematosus (SLE)-like disease, thus highlighting the importance of SCARF1-mediated clearance of apoptotic host cells in homeostasis. In addition, a number of other roles in homeostasis and disease pathology have also been suggested, including roles in both innate and adaptive immunity; however, the majority of these studies have utilised transfected cell lines engineered to ectopically express SCARF1 and very few have utilised in vivo or ex vivo approaches.ConclusionThis review summarises our current knowledge on SCARF1 biology and reflects on future directions for research on this multifaceted, yet largely understudied, scavenger receptor.

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“…The scavenger receptor A (SRA) is expressed primarily on myeloid cells, such as macrophages and dendritic cells (DCs) (Beauvillain et al, 2010). SRA represents an important class of pattern recognition receptors shown to mediate both beneficial and detrimental roles in host defense against microbial pathogens (Qiu et al, 2013;Navarro-Noya et al, 2013;Sra et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Scavenger receptor SRA attenuates microglia activation and protects neuroinflammatory injury in intracerebral hemorrhage

Yang

Zhong

Liu³

et al. 2015

Journal of Neuroimmunology

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The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells

Cited by 38 publications

References 38 publications

Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family

Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family

SCARF1: a multifaceted, yet largely understudied, scavenger receptor

Scavenger receptor SRA attenuates microglia activation and protects neuroinflammatory injury in intracerebral hemorrhage

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