The Scenario of Recurrence of Cervical Cancer by Epigenetics

Abstract

Epigenetic changes happen all the time during life, however, some differences are responsible for specific diseases. One such disease is cancer; nevertheless, a cancer recurrence can be exceedingly lethal and hasten the demise process. Epigenetic changes have the power to completely rule out all current modalities of treatment and have a rapid and substantial impact on the recurrence of cancer. Research indicates that recurrences may occur in up to 70% of individuals with stage III to IVB of cervical cancer. Even with extensive therapy, the 5-year overall survival (OS) rate for recurrent cervical cancer is less than 5%, and the disease is still extremely difficult to treat. This is particularly true for those who experience recurrence in a region that has previously undergone radiation treatment. Therefore, it is important to comprehend the role that epigenetic plays in cervical cancer recurrence since this will provide novel opportunities for treatment options. The purpose of this study was to evaluate the current developments in the field of epigenetic research on cervical cancer recurrence, including the role these alterations play in the evolution of the illness, their prognostic significance, and their application in targeted therapy.