The schizophrenia prodrome: treatment and high-risk perspectives

Cornblatt, Barbara A.; Lencz, Todd; Obuchowski, M.

doi:10.1016/s0920-9964(01)00365-6

Cited by 148 publications

(106 citation statements)

References 33 publications

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“…This earliest stage could, in retrospect, be termed the "prodrome", i.e., the precursor of the psychotic stage. However, since we can only apply the term "prodrome" with certainty if the definitive psychotic stage does indeed develop, terms such as the "ultra-high risk" (34) or "clinical high risk" (45) stage have been developed to indicate that psychosis is not inevitable and that false positive cases also occur. This symptomatic yet prepsychotic stage is the earliest point at which preventive interventions for psychosis can concurrently be conceived (46).…”

Section: The Stages Of Early Psychosis Stage 1: Ultra-high Riskmentioning

confidence: 99%

Early intervention in psychosis: concepts, evidence and future directions

2008

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Section: The Stages Of Early Psychosis Stage 1: Ultra-high Riskmentioning

confidence: 99%

Early intervention in psychosis: concepts, evidence and future directions

2008

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“…Alternatively, 'close in' i.e. clinical high-risk approaches are able to identify a group at ultra high-risk of psychosis with higher transition rates than those observed in studies purely based on genetic inclusion criteria (Cornblatt et al, 2002;McGlashan and Johannessen, 1996;Pantelis et al, 2007;Yung et al, 1998). The latter approach, focusing on individuals who are considered to be at increased risk for psychotic disorders, is based primarily on the presence of clinical symptoms.…”

Section: High-risk Research Paradigmsmentioning

confidence: 99%

Neuroimaging predictors of transition to psychosis—A systematic review and meta-analysis

Smieskova

Fusar‐Poli

Allen

et al. 2010

Neuroscience & Biobehavioral Reviews

280

219

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Objectives: In early stage psychosis research is the identification of neurobiological correlates of vulnerability to schizophrenia an important hurdle.Methods: We conducted a systematic review of the neuroimaging publications on high-risk subjects with subsequent transition to psychosis (HR-T) and conducted a meta-analysis using the Cohen's d.Results: Out of 30 identified studies 25 met the inclusion criteria. sMRI studies showed small to medium effect sizes of decreased prefrontal, cingulate, insular and cerebellar gray matter volume in HR-T compared to high-risk subjects without transition (HR-NT) and reduced temporal cortex in first episode (FE) of psychosis subjects compared to HR-T.Compared to HR-NT, HR-T subjects showed in functional imaging studies reduced brain activation in prefrontal cortex, reduced neuronal density, increased membrane turnover in frontal and cingulate cortex and decreased availability of serotonine receptors in prefrontal cortex with medium to large effect sizes.Conclusions: Despite methodological differences between studies, structural and neurochemical abnormalities in prefrontal, anterior cingulate, medial temporal and cerebellar cortex might be predictive for development of psychosis within HR subjects.

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“…66 The transition rate to schizophrenia in the schizophrenia-like psychosis group was 33%. 92 This approach of further refining and characterizing subclasses of CHR states facilitates the implementation of more specific hypothesis-driven experimental paradigms, particularly in the interests of predicting relatively discrete or parsed cognitive processes that may be differentially related to CHR subclasses.…”

Section: Recognition and Prevention (Rap) Programmentioning

confidence: 99%