The Science of Absorbable Poly(L-Lactide-Co-ϵ-Caprolactone) Threads for Soft Tissue Repositioning of the Face: An Evidence-Based Evaluation of Their Physical Properties and Clinical Application

Wong, Vincent

doi:10.2147/ccid.s274160

Cited by 28 publications

(45 citation statements)

References 17 publications

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“…The double needle threads are convergent bidirectional barbs and are available in 12-or 23-cm versions with 9-or 15-cm 24G straight needles at both Fig. 7 Patients' self-assessment on the improvement in lower facial laxity at baseline and follow-up visits thread extremities [20,28]. The subdermal suspension threads lift the tissues by connecting to the dermis retinacula cutis system, the SMAS, and the downward muscular bands [20].…”

Section: Discussionmentioning

confidence: 99%

“…Thread resorption most likely occurred between 8 and 12 months post-procedure. Based on previous studies and the thread’s composition, neocollagenesis was most likely initiated at 1 month post-implantation [ 18 , 23 , 26 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we used Definisse™ threads, which consist of absorbable p(LA-CL) monofilaments that provide subdermal support or filling, confer elasticity, and prolong thread stability when implanted [ 26 , 28 ]. The double needle threads are convergent bidirectional barbs and are available in 12- or 23-cm versions with 9- or 15-cm 24G straight needles at both thread extremities [ 20 , 28 ]. The subdermal suspension threads lift the tissues by connecting to the dermis retinacula cutis system, the SMAS, and the downward muscular bands [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…The tissue areas containing Definisse™ double needle threads undergo neocollagenesis and elastogenesis, as evidenced by mast cell migration, uniform fibrous encapsulation of the threads, and dermal thickening of the adjacent tissues [ 23 ]. Following implantation, threads can induce neocollagenesis, elastogenesis, hyaluronic acid production, and angiogenesis for up to 15 months before total reabsorption occurs, thus providing up to 36 months of progressive tissue lifting and revitalization [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Absorbable Barbed Threads for Lower Facial Soft-Tissue Repositioning in Asians

Wanitphakdeedecha

Yan

et al. 2021

Dermatol Ther (Heidelb)

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Introduction: Asian patients often seek to address lower facial aging through clinical interventions that increase anterior projection and jawline contouring. The Definisse TM (also known as Happy Lift TM ) thread lift treatment uses barbed absorbable threads to suspend tissues and induce biostimulation. We evaluated the efficacy and safety of absorbable barbed threads for lower facial reshaping in Thai patients. Methods: This prospective, evaluator-blinded study enrolled 27 Thai patients diagnosed with mild to moderate facial laxity. Patients underwent thread implantation along the mandibular angle with one of two double needle thread lengths (12 and 23 cm) to create a ''J stitch''. Primary outcome was the clinical improvement in facial laxity as graded by two blinded dermatologists at baseline, immediately after treatment, and at 1 week and 1, 2, 3, 6, and 12 months follow-up. Objective measurements included volume in the jawline, nasolabial folds, and submental area. Patients' self-assessment scores and adverse reactions were recorded. Results: Of the 27 patients recruited to the study, 25 (92.6%) attended all follow-up visits. Clinical improvement of facial laxity was observed immediately after thread implantation. There was significant volume improvement in the jawline, nasolabial folds and submental area at almost all follow-up visits (p \ 0.007), with most patients (51.9%) reporting excellent lifting effect as early as the 1 week follow-up visit. All adverse reactions were mild and resolved spontaneously without any medical intervention. Conclusion: Implantation of absorbable barbed threads is a safe and effective treatment for facial rejuvenation in Thai patients. Long threads (23 cm) showed a slight superiority to short threads (12 cm) in terms of face-lifting efficacy, which suggests the benefit of additional barbs in tissue suspension and biostimulation. The disadvantage of absorbable threads is that their visible lifting effects are not as longlasting as those of non-absorbable ones, since they are reabsorbed from 6 months onwards. Trial registration: ClinicalTrials.gov identifier: TCTR20210415001. This clinical trial was retrospectively registered 12 April 2021.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Absorbable Barbed Threads for Lower Facial Soft-Tissue Repositioning in Asians

Wanitphakdeedecha

Yan

et al. 2021

Dermatol Ther (Heidelb)

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“…Aside from the individual effects of each contributing anatomic structure and the clinically visible difference between individuals of different genders, ethnicities, and cultural backgrounds, facial soft tissues tend to descend with increasing age. Repositioning facial soft tissues is one of the major goals of a facelift, [12][13][14][15] suspension thread procedures, [16][17][18] and some of the novel soft tissue filler injection techniques. 19,20 All of the above-mentioned techniques aim to relocate facial soft tissues toward their original position-often in a more cranial and/or lateral direction.…”

Section: Introductionmentioning

confidence: 99%

Soft tissue filler augmentation of the orbicularis retaining ligament to improve the lid‐cheek junction

Bernardini¹,

Casabona²,

Alfertshofer

et al. 2021

J of Cosmetic Dermatology

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Background:The orientation of facial ligaments changes with increasing age due to the loss of bony support. Soft tissue filler injections placed in close proximity to facial ligaments can alter their orientation to help achieve an improved and younger aesthetic appearance.Objective: To assess the anatomic and aesthetic effects of a standardized injection with soft tissue filler placed directly inferior to the orbicularis retaining ligament in the infraorbital region.Methods: A total of 163 patients with signs of infraorbital aging were treated with a standardized soft tissue filler injection into and in close proximity to the orbicularis retaining ligament (ORL). 2D frontal images of the infraorbital region were rated by eleven blinded and independent raters with regards to the aesthetic appearance of the infraorbital region before and after the standardized injection treatment. Results:The aesthetic appearance of the entire infraorbital region (lid-cheek junction) was rated before and after the treatment. The severity of the tear trough (medial aspect of the infraorbital region) as well as the hollowing of the lateral aspect of the infraorbital region also was rated before and after the treatment. Aesthetic improvement was statistically significant when evaluated by the blinded raters, the treating physician, and the patients. All the results were "very much improved" compared to baseline. Conclusion:The effectiveness of this injection technique is thought to be due to the strategic placement of soft tissue filler that helps to reposition facial ligaments that have changed their orientation during the aging process.

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Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open‐heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion devices used in clinical settings are primarily composed of Nitinol as the skeleton. Nevertheless, long‐term follow‐up studies have revealed various complications related to metal skeletons, including hemolysis, thrombus, metal allergy, cardiac erosion, and even severe atrioventricular block. Thus, occlusion devices made of biodegradable materials have become the focus of research. Over the past two decades, several bioabsorbable cardiac occluders for ventricular septal defect and atrial septal defect have been designed and trialed on animals or humans. This review summarizes the research progress of bioabsorbable cardiac occluders, the advantages and disadvantages of different biodegradable polymers used to fabricate occluders, and discusses future research directions concerning the structures and materials of bioabsorbable cardiac occluders.

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The Science of Absorbable Poly(L-Lactide-Co-ϵ-Caprolactone) Threads for Soft Tissue Repositioning of the Face: An Evidence-Based Evaluation of Their Physical Properties and Clinical Application

Cited by 28 publications

References 17 publications

Absorbable Barbed Threads for Lower Facial Soft-Tissue Repositioning in Asians

Absorbable Barbed Threads for Lower Facial Soft-Tissue Repositioning in Asians

Soft tissue filler augmentation of the orbicularis retaining ligament to improve the lid‐cheek junction

Progress of biodegradable polymer application in cardiac occluders

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