The Scourge of HIV Infection in Sub-Saharan Africa — A Rheumatological Perspective

Tikly, Mohammed

doi:10.3899/jrheum.110119

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…[64] This pandemic has both diagnostic and therapeutic implications for the management of patients with concomitant inflammatory arthritis. [65] HIV infection can cause, among other musculoskeletal syndromes, inflammatory polyarthritis mimicking RA. [66] Hence, an HIV test may be appropriate in a patient presenting with inflammatory arthritis.…”

Section: Hiv Infectionmentioning

confidence: 99%

South African recommendations for the management of rheumatoid arthritis: An algorithm for the standard of care in 2013

et al. 2013

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Section: Hiv Infectionmentioning

confidence: 99%

South African recommendations for the management of rheumatoid arthritis: An algorithm for the standard of care in 2013

et al. 2013

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“…The safety of MTX in patients who are HIV positive is uncertain. In patients with low CD4 counts, MTX may predispose patients further to opportunistic infections, including TB [ 15 ]. The use of MTX in HIV positive individuals may be acceptable in the setting of a CD4 count >200, particularly if ARV therapies are prescribed and if the patient is closely followed up.…”

Section: Discussionmentioning

confidence: 99%

HIV Infection and Osteoarticular Tuberculosis: Strange Bedfellows

Hodkinson

Osman

Botha-Scheepers

2016

Case Reports in Rheumatology

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We report the case of a 47-year-old female patient with rheumatoid arthritis and HIV infection presenting with a 3-week history of a painful swollen knee, increased serum inflammatory markers, and a low CD4 lymphocyte count. The diagnosis of TB arthritis was made by synovial fluid culture, GeneXpert/PCR, and confirmed by histopathology of a synovial biopsy. A mini literature review suggests that although HIV infection is associated with extrapulmonary TB, osteoarticular TB is a relatively unusual presentation in an HIV positive patient. The diagnostic utility of the GeneXpert test is explored. We also describe the patient's good response to an intra-articular corticosteroid injection in combination with standard anti-TB therapy.

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“…The condition is limited to a specific geographical region in northern Kwazulu Natal [ 2 ]. Due to the high incidence of human immunodeficiency virus (HIV) disease in South Africa, typical features of HIV arthropathy are dealt with frequently and well described [ 3 ]. Arthralgia is present in 46% of the HIV population.…”

Section: Rheumatology In South Africamentioning

confidence: 99%

“…In South Africa, the burden of HIV infection is amongst the highest in the world, with an estimated 33% of females between the ages of 25 and 29 years infected in 2010 [ 70 ]. This pandemic has both diagnostic and therapeutic implications for the management of patients with concomitant inflammatory arthritis [ 3 ].…”

Section: Complications and Safety Issuesmentioning

confidence: 99%

“…Uncontrolled severe joint inflammation, extra-articular disease, physical inactivity, and corticosteroid use further contribute to the risk of cardiovascular events [ 80 ]. Improved disease control with therapy, such as MTX and anti-TNF therapy, has been shown to decrease cardiovascular risk in RA patients [ 3 , 81 ].…”

Section: Complications and Safety Issuesmentioning

confidence: 99%

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The specialist physician’s approach to rheumatoid arthritis in South Africa

Bester¹,

Bosch²,

Rensburg

2016

Korean J Intern Med

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Rheumatoid arthritis (RA) is expected to increase in Africa and South Africa. Due to the low numbers of rheumatologists in South Africa, specialist physicians also have to care for patients with RA. Furthermore several new developments have taken place in recent years which improved the management and outcome of RA. Classification criteria were updated, assessment follow-up tools were refined and above all, several new biological disease-modifying anti-rheumatic drugs were developed. Therefore it is imperative for specialist physicians to update themselves with the newest developments in the management of RA. This article provides an overview of the newest developments in the management of RA in the South African context. This approach may well apply to countries with similar specialist to patient ratios and disease profiles.

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The Scourge of HIV Infection in Sub-Saharan Africa — A Rheumatological Perspective

Cited by 6 publications

References 16 publications

South African recommendations for the management of rheumatoid arthritis: An algorithm for the standard of care in 2013

South African recommendations for the management of rheumatoid arthritis: An algorithm for the standard of care in 2013

HIV Infection and Osteoarticular Tuberculosis: Strange Bedfellows

The specialist physician’s approach to rheumatoid arthritis in South Africa

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