The <scp>DR</scp>7‐<scp>DQ</scp>2 Haplotype in a Native Norwegian Population

Heide, Gøril; Stuge, Tor B.; Skogen, Bjøŕn; Husebekk, Anne; Ahlén, Maria Therese

doi:10.1111/sji.12031

Cited by 1 publication

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“…In support of the latter, DQ2 is associated with alloimmunization also by a second allele not linked to DR3-DQ2. This second allele, DQB1*02:02, is present in the DR7-DQ2 haplotype, 33 which is the only other DR-DQ haplotype including DQ2 besides DR3-DQ2. 15 The DQB1*02:02 allele and, thus, the DR7-DQ2 haplotype are present at a higher frequency in HPA-1a-alloimmunized DRB3*01:01-positive women compared to in DRB3*01:01-positive individuals in the general population.…”

Section: Discussionmentioning

confidence: 99%

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The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB301:01* allele and associated DR‐DQ haplotypes

et al. 2020

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Alloimmunization against human platelet antigen (HPA)‐1a during pregnancy can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) and severe bleeding in the foetus or newborn and likely depends on several factors. HPA‐1a alloimmunization is associated with DRB3*01:01, which is associated with several DR‐DQ haplotypes. However, it is not known to what extent these haplotypes contribute to the prevalence of HPA‐1a alloimmunization. HPA‐1a–alloimmunized women, identified in a prospective study, and random donors were typed for selected DRB3, DRB4, DRB1, DQA1 and DQB1 alleles to determine allele and DR‐DQ haplotype frequencies. DRB3*01:01 was carried by 94% HPA‐1a–immunized women compared to 27% in the general population. In the first population, the DR3‐DQ2 haplotype was overrepresented (P < .003). The prevalence of HPA‐1a alloimmunization was estimated to be about twice as frequent with DR3‐DQ2 compared to DR13‐DQ6, together accounting for about 90% of DRB3*01:01–positive individuals. Further, we examined DQB1*02 and DRB4*01:01 alleles for their reported association with HPA‐1a alloimmunization, in the context of DR‐DQ haplotypes. Since ~ 80% of DQB1*02 alleles are linked to the DR3‐DQ2 haplotype, the association might be coincidental. However, the DQB1*02:02–associated DR7‐DQ2 haplotype was also overrepresented in alloimmunized women, suggesting a role for this allele or haplotype in HPA‐1a alloimmunization. As DRB4*01:01 is predominantly associated with the DR7‐DQ2 haplotype in HPA‐1a–alloimmunized individuals, the reported association with FNAIT may be coincidental. Typing for DR‐DQ haplotypes revealed important genetic associations with HPA‐1a alloimmunization not evident from typing individual alleles, and the presence of different DRB3‐associated DR‐DQ haplotypes showed different prevalence of HPA‐1a alloimmunization.

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Section: Discussionmentioning

confidence: 99%

“…In support of the latter, DQ2 is associated with alloimmunization also by a second allele not linked to DR3‐DQ2. This second allele, DQB1*02:02 , is present in the DR7‐DQ2 haplotype, 33 which is the only other DR‐DQ haplotype including DQ2 besides DR3‐DQ2 15…”

Section: Discussionmentioning

confidence: 99%

The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB301:01* allele and associated DR‐DQ haplotypes

et al. 2020

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show abstract

The DR7‐DQ2 Haplotype in a Native Norwegian Population

Cited by 1 publication

References 10 publications

The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB301:01* allele and associated DR‐DQ haplotypes

The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB301:01* allele and associated DR‐DQ haplotypes

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The DR7‐DQ2 Haplotype in a Native Norwegian Population

Cited by 1 publication

References 10 publications

The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR‐DQ haplotypes

The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR‐DQ haplotypes

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The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB301:01* allele and associated DR‐DQ haplotypes

The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB301:01* allele and associated DR‐DQ haplotypes