This paper analyses the science-policy interactions in the field of flood risk governance against the background of climate change. By the example of three neighbouring Alpine regions (Switzerland, Southern Germany and Austria), the study strives to shed further light on how flood risk governance regimes embrace the possible impacts of climate change. It builds on the assumption that flood risk management, as a 'technical' policy field, is strongly influenced by scientific evidence and that differences in how countries incorporate climate change can be explained by the way science and policy are brought together in the respective national arenas. We structure the empirical analysis along three dimensions: (i) dynamics of knowledge creation; (ii) institutionalization of the science-policy interface; and (iii) pathways of influence of expertise on policy development. We find that there is a mixed, though increasing influence of climate change on flood risk governance in the three selected Alpine regions. Climate adaptation has become an important issue of flood policy in all three study areas, and this shift has been strongly supported by evidence-based arguments.