2014
DOI: 10.1002/ijc.29293
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The Hippo pathway in chemotherapeutic drug resistance

Abstract: Chemotherapy is one of the major treatments for cancer patients. Although chemotherapeutic drugs can sometimes effectively suppress tumor growth in cancer patients, a significant proportion of patients are either intrinsically resistant or later develop resistance to primary chemotherapy, leading to disease relapse and patient mortality. The best way to conquer the resistance is the better understanding of the molecular network in cancer cells in response to drugs. Therefore, identification of signaling pathwa… Show more

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Cited by 85 publications
(73 citation statements)
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References 102 publications
(216 reference statements)
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“…5,7,[16][17][18][19][20][21][22][23][24][25] The core components of this pathway are composed of two serine/threonine (S/T) kinases Mst1 and its homolog Mst2 (mammalian homolog of Drosophila Hippo) and LATS1 and its homolog LATS2, two adaptor/scaffold proteins hMOB1 and WW45 and two WW domaincontaining transcriptional co-activators TAZ and its paralog YAP (Fig. 5,7,[16][17][18][19][20][21][22][23][24][25] The core components of this pathway are composed of two serine/threonine (S/T) kinases Mst1 and its homolog Mst2 (mammalian homolog of Drosophila Hippo) and LATS1 and its homolog LATS2, two adaptor/scaffold proteins hMOB1 and WW45 and two WW domaincontaining transcriptional co-activators TAZ and its paralog YAP (Fig.…”
Section: The Hippo Pathwaymentioning
confidence: 99%
“…5,7,[16][17][18][19][20][21][22][23][24][25] The core components of this pathway are composed of two serine/threonine (S/T) kinases Mst1 and its homolog Mst2 (mammalian homolog of Drosophila Hippo) and LATS1 and its homolog LATS2, two adaptor/scaffold proteins hMOB1 and WW45 and two WW domaincontaining transcriptional co-activators TAZ and its paralog YAP (Fig. 5,7,[16][17][18][19][20][21][22][23][24][25] The core components of this pathway are composed of two serine/threonine (S/T) kinases Mst1 and its homolog Mst2 (mammalian homolog of Drosophila Hippo) and LATS1 and its homolog LATS2, two adaptor/scaffold proteins hMOB1 and WW45 and two WW domaincontaining transcriptional co-activators TAZ and its paralog YAP (Fig.…”
Section: The Hippo Pathwaymentioning
confidence: 99%
“…It is crucial for tissue homeostasis, cell proliferation, development, and stem cell renewal [61]. It has recently been recognized to have a role in cancer and chemoresistance [55,62]. Although the core Hippo pathway has been characterized, the regulatory mechanisms that affect this signaling cascade are poorly understood.…”
Section: Figmentioning
confidence: 99%
“…It is proposed as a major regulator of cell proliferation, cell migration and invasion, epithelial-mesenchymal transition (EMT), human embryonic stem cell renewal, and drug resistance (21)(22)(23)(24)(25)(26)(27). Within the N terminus of TAZ lies a TEAD binding domain (TBD) responsible for the interaction with the TEAD family of transcription factors.…”
mentioning
confidence: 99%