TheMichael Reaction*This cooperative study was begun when the three authors were working at the Weizmann Institute of Science, Rehovoth.

Abstract

The Michael condensation in its original scope is the addition of an addend or donor containing an alpha‐hydrogen atom in the system OCCH to a carbon‐carbon double bond that forms part of a conjugated system of the general formula CCCO in an acceptor. The condensation takes place under the influence of alkaline reagents, typically alkali metal alkoxides. The range of addends is very broad. Typical acceptors are alpha, beta‐unsaturated aldehydes, keotnes, and acid derivatives. As an extension of the original scope, the Michael condensation has come to be understood to include addends and acceptors activated by groups other than carbonyl and carboxalkoxy. The wider scope is encompassed in this survey.

Crown Ether Complex Cation Ionic Liquids: Preparation and Applications in Organic Reactions

“…The Michael addition is traditionally catalysed by strong bases. [12] ILs have recently been used as catalysts and solvents in Michael additions. [13] The complexation of a potassium or sodium cation to a crown ether increases the radius of the cation, which decreases the electrostatic interactions between ion pairs and, consequently, enhances the basicity/ nucleophilicity of the anion in [OH] and [18-C-6K] [OH].…”

“…To further extend the scope of application of CECILs, the CECILs of [18-C-6K] PO 4 ] were applied in the Heck reaction as additives (Table 6, Table 6, it can be seen that the reaction can take place under mild conditions (110 8C) when the active aryl halide iodobenzene is used (Table 6 < xtabr6, entries [11][12][13][14]. When bromobenzene was used as the substrate, the reaction required a higher temperature (140 8C) (Table 6 < xtabr6, entries 15-18).…”

Synthesis, Characterization and Antimicrobial Activity of Novel Chalcones Analogues

“…Chalcones possess conjugated double bonds and a completely delocalized π-system on both benzene rings. Chalcones have been used as intermediate for the preparation of compounds having therapeutic value [5][6][7] . Chalcones and their derivatives, whether synthetic or naturally occurring are an interesting and significant group of molecules as they possess a wide range of pharmacological activities such as anti-inflammatory, antimicrobial, antifungal, antibacterial, antioxidant, cytotoxic antitumor, anticancer, antimitotic, antileishmanial, antimalarial, antitubercular, antiviral and so on [8][9][10][11][12][13][14][15][16][17][18][19][20][21] .…”

Triethylamine and TBD supported on silica: useful heterogeneous catalysts for the reaction of β-dicarbonyl derivatives with α,β-unsaturated compounds under batch and continuous flow conditions

“…10 These reactions are usually performed in the presence of strong bases (i.e. alkali metal alkoxides and hydroxides), 11 transition metal complexes, 12 solid acids (i.e. alumina and clays), [13][14][15] …”