The <scp>UK</scp> national evaluation of the development and impact of <scp>E</scp>arly <scp>I</scp>ntervention <scp>S</scp>ervices (the <scp>N</scp>ational <scp>EDEN</scp> studies): study rationale, design and baseline characteristics

Birchwood, Max; Lester, Helen; McCarthy, Linda; Jones, Peter B.; Fowler, David; Amos, Tim; Freemantle, Nick; Sharma, Vimal; Lavis, Anna; Singh, Swaran P.; Marshall, Max

doi:10.1111/eip.12007

Cited by 70 publications

(83 citation statements)

References 43 publications

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“…We should not be too surprised by these findings since historical 22 and recent data 23 suggest that young people with psychosis do not engage well with out-patient services such as CMHTs and are often discharged as a result. Indeed, the evidence base for the effectiveness of CMHTs in managing schizophrenia was reviewed in recent National Institute for Health and Care Excellence (NICE) guidelines 36 concluding, 'Despite the fact that CMHTs remain the mainstay of community mental healthcare, there is surprisingly little evidence to show that they are an effective way of organising services.…”

Section: Impact Of First Mental Health Service Contact On Dupmentioning

confidence: 99%

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Reducing Duration of Untreated Psychosis: Care Pathways to Early Intervention in Psychosis Services

Birchwood¹,

Connor²,

Lester³

et al. 2014

Schizophrenia Research

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Section: Impact Of First Mental Health Service Contact On Dupmentioning

confidence: 99%

“…23 Graduate research psychologists who had completed comprehensive training conducted interviews and DUP calculations to acceptable reliability. Research staff in National EDEN underwent an annual check on DUP reliability.…”

Section: Duration Of Untreated Psychosismentioning

confidence: 99%

Reducing Duration of Untreated Psychosis: Care Pathways to Early Intervention in Psychosis Services

Birchwood¹,

Connor²,

Lester³

et al. 2014

Schizophrenia Research

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“…The sample comprises participants in the National EDEN study: a national evaluation of the impact and cost-effectiveness of Early Intervention in Psychosis (EIP) services in the UK (Birchwood et al, 2014). All individuals accepted into EIP services in Birmingham, Bristol, Cambridge, Cornwall, Lancashire and Norfolk between August 2005 and April 2009 were invited to take part.…”

Section: Participantsmentioning

confidence: 99%

The course of negative symptom in first episode psychosis and the relationship with social recovery

Gee

Hodgekins

Fowler

et al. 2016

Schizophrenia Research

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(2016) The course of negative symptom in first episode psychosis and the relationship with social recovery. Schizophrenia Research,. 065-171. Permanent WRAP URL:http://wrap.warwick.ac.uk/79034 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. Method: 1006 participants were followed up for 12 months following acceptance into EarlyIntervention in Psychosis services. Negative symptom trajectories were modelled using latent class growth analysis (LCGA) and predictors of trajectories examined using multinomial regression. Social recovery trajectories -also modelled using LCGA -of members of each negative symptom trajectory were ascertained and the relationship between negative symptom and social recovery trajectories examined. proportion of FEP patients with elevated negative symptoms at baseline will achieve remission of these symptoms within 12 months. However, elevated negative symptoms at baseline, whether or not they remit, are associated with poor social recovery, suggesting targeted interventions for service users with elevated baseline negative symptoms may help improve functional outcomes. Results

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“…Duration of untreated psychosis (DUP) was defined as the delay between the onset of psychosis and the onset of criteria treatment and was calculated using a robust strategy (for more information, see article by Birchwood et al 16 ). A dichotomous DUP variable was constructed representing short (0 = <6 months) and long (1 = >6 months) DUP.…”

Section: Potential Confounders Drug Use and Duration Of Untreated Psymentioning

confidence: 99%

“…Comprehensive ethical approval for this study was granted by the South West Multicentre Research Ethics Committee. A total of 1 027 individuals consented to the study (50% of those approached; see article by Birchwood et al 16 for information on nonresponders). The violent behavior outcome was available at both points for 670 individuals (65% of the consented group).…”

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confidence: 99%

Pathways to Violent Behavior During First-Episode Psychosis

et al. 2013

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IMPORTANCE Although many studies have explored the correlates of violence during first-episode psychosis (FEP), most have simply compared violent psychotic individuals with nonviolent psychotic individuals. Accumulating evidence suggests there may be subgroups within psychosis, differing in terms of developmental processes and proximal factors associated with violent behavior.OBJECTIVE To determine whether there are subgroups of psychotic individuals characterized by different developmental trajectories to violent behavior. DESIGN, SETTING, AND PARTICIPANTSThe National EDEN (Evaluating the Development and Impact of Early Intervention Services in the West Midlands) Study longitudinal cohort assessed premorbid delinquency (premorbid adjustment adaptation subscale across childhood and adolescence), age at illness onset, duration of untreated psychosis, past drug use, positive symptoms, and violent behavior. Group trajectories of premorbid delinquency were estimated using latent class growth analysis, and associations with violent behavior were quantified. This study included 6 early intervention services in 5 geographical locations across England, with violent behavior information available for 670 first-episode psychosis cases. MAIN OUTCOMES AND MEASURESViolent behavior at 6 or 12 months following early intervention services entry.RESULTS Four groups of premorbid delinquency were identified: stable low, adolescent-onset high to moderate, stable moderate, and stable high. Logistic regression analysis, with stable low delinquency as the reference group, demonstrated that moderate (odds ratio, 1.97; 95% CI, 1.12-3.46) and high (odds ratio, 3.53; 95% CI, 1.85-6.73) premorbid delinquency trajectories increased the risk for violent behavior during FEP. After controlling for confounders, path analysis demonstrated that the increased risk for violence in the moderate delinquency group was indirect (ie, partially mediated by positive symptoms) (probit coefficient [β] = 0.12; P = .002); while stable high delinquency directly increased the risk for violence (β = 0.38; P = .05). CONCLUSIONS AND RELEVANCEThere appear to be diverse pathways to violent behavior during FEP. Stable high premorbid delinquency from childhood onwards appears to directly increase the risk for violent behavior, independent of psychosis-related risk factors. In addition to tackling illness-related risks, treatments should directly address antisocial traits as a potent risk for violence during FEP.

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The UK national evaluation of the development and impact of Early Intervention Services (the National EDEN studies): study rationale, design and baseline characteristics

Cited by 70 publications

References 43 publications

Reducing Duration of Untreated Psychosis: Care Pathways to Early Intervention in Psychosis Services

Reducing Duration of Untreated Psychosis: Care Pathways to Early Intervention in Psychosis Services

The course of negative symptom in first episode psychosis and the relationship with social recovery

Pathways to Violent Behavior During First-Episode Psychosis

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