2024
DOI: 10.3389/fmars.2024.1498223
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The screening and anti-Raji lymphoma effect of Chiloscyllium plagiosum anti-CD20 VNARs

Qingyu Ren,
Yu Sheng,
Ling Sun
et al.

Abstract: IntroductionB-cell lymphoma, a malignant proliferative disease originating from lymphoid tissue, poses a grave threat to human health. CD20 has emerged as a promising target for lymphoma treatment. However, due to the significant heterogeneity of B-cell lymphomas, conventional CD20 monoclonal antibodies show limited penetration, severely impeding the progress of B-cell lymphoma therapies.MethodsIn contrast, single-domain antibody molecules derived from cartilaginous fish have a molecular weight as small as 12 … Show more

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