The screening and electron microscopy observation of mammary analogue secretory carcinoma in Chinese

Zhong, Yi; Liu, Liu; Qi, Bin; Song, Xuejiao; Shen, Linhan; Li, Hongwei

doi:10.1016/j.jcms.2017.10.007

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…Our study also adds to the limited number of reports describing the ultrastructural features of MASC. Only 3 studies on electron microscopic findings in MASC have been published to date [6,7,16]. As in the previous studies, our case showed the presence of small electron dense secretory granules which were not described in the single reported case of EM findings in intraductal carcinoma [17].…”

Section: Conflicts Of Interestsupporting

confidence: 68%

“…Since the rst publication describing MASC as a distinct entity in the salivary glands by Skálová et. al in 2010 [1], there has been a urry of interest in this tumor including case series and literature reviews describing morphologic, immunohistochemical, and ultrastructural ndings [2,[4][5][6][7][8]. However, the diagnosis remains challenging in certain cases; MASC can show considerable morphologic overlap with other salivary gland tumors including acinic cell carcinoma and intraductal carcinoma (formerly called low grade salivary duct carcinoma or cribriform cystadenocarcinoma) [9].…”

Section: Introductionmentioning

confidence: 99%

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A Challenging Case of Mammary Analogue Secretory Carcinoma: Case Study with Ultrastructural and Cytogenetic Correlation

Mathew

Carvalho

Chorneyko³

et al. 2019

Case Reports in Pathology

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Mammary analogue secretory carcinoma (MASC) is a rare salivary gland tumor analogous to secretory carcinoma of the breast. The diagnosis of MASC can be challenging due to substantial morphologic and immunohistochemical similarities with other salivary gland tumors. The differential diagnosis of MASC is broad and includes intraductal carcinoma, acinic cell carcinoma, and adenocarcinoma, not otherwise specified. Although molecular testing for ETV6 gene rearrangement is characteristic of MASC and has not been shown in any other salivary gland tumor, a particular challenge arises when such testing is unavailable, or when molecular testing for ETV6 gene rearrangement is negative in a suspected case of MASC. Our study presents the diagnostic workup of a challenging case of MASC with immunohistochemistry, electron microscopy, and cytogenetic studies performed to resolve the diagnosis.

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Section: Conflicts Of Interestsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

A Challenging Case of Mammary Analogue Secretory Carcinoma: Case Study with Ultrastructural and Cytogenetic Correlation

Mathew

Carvalho

Chorneyko³

et al. 2019

Case Reports in Pathology

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“…Upon reviewing published data, the microscopic structures of SCs were found diverse, including solid types, papillary cystic, glandular tubular, and striated structures. 2 , 17 , 18 Tumor cells were eosinophilic and round or ovoid with abundant cytoplasm, and were usually multivesicular and lipid-rich. 9 Malignant SCs usually structurally presented as solid-type or trabecular-type with larger tumor cells, together with more visible necrosis, indicating its heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of 18 cases of secretory carcinoma of the salivary glands

Wang

Yang

Yao

et al. 2024

Journal of Dental Sciences

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“…MASC is typically negative for high-molecular-weight keratin and basal cell/myoepithelial markers, such as calponin, SMA, CK5, CK6, CK14, and p63. The defining cytogenetic characteristic of MASC is the presence of the t(12;15)(q13;q25) ETV6-NTRK3 translocation, demonstrated by either FISH or PCR [9].…”

Section: Discussion/conclusionmentioning

confidence: 99%

A Cribriform Cancer Metastatic to Liver: Case Report and Literature Review

2019

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Metastasis from salivary gland tumors to liver is exceedingly uncommon. Reported is the first case of a mammary analog secretory carcinoma (MASC) of salivary gland origin metastasized to the liver, even after complete surgical resection. A 76 year old female, with past history of a completely extirpated right parotid gland MASC, presented 2 years after right superficial parotidectomy and right neck dissection, with back and flank pain. Subsequent abdominal and pelvic CT revealed multiple small hepatic lesions. Biopsy of the largest hepatic lesion confirmed metastatic MASC of primary parotid gland origin. Both the parotid primary and the hepatic metastases had the confirmatory ETV6 rearrangement by fluorescence in situ hybridization. Although high-grade malignancy and distant metastases of MASC of salivary gland origin to liver is rare, recognizing metastatic MASC potentially alters prognosis and determines therapeutic options.

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The screening and electron microscopy observation of mammary analogue secretory carcinoma in Chinese

Cited by 7 publications

References 24 publications

A Challenging Case of Mammary Analogue Secretory Carcinoma: Case Study with Ultrastructural and Cytogenetic Correlation

A Challenging Case of Mammary Analogue Secretory Carcinoma: Case Study with Ultrastructural and Cytogenetic Correlation

Clinicopathological analysis of 18 cases of secretory carcinoma of the salivary glands

A Cribriform Cancer Metastatic to Liver: Case Report and Literature Review

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