The search for thrombophilic gene mutations in women with gestational hypertension does not help in predicting poor pregnancy outcome

D’Aniello, Gemma; Florio, Pasquale; Severi, Filiberto Maria; Fineschi, Daniela; Cito, Giuseppe; Guidoni, C. G.

doi:10.1097/00004872-200310000-00019

Cited by 13 publications

(5 citation statements)

References 26 publications

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“…However, Cotter et al (153,156) found that elevated tHcy at Ȃ15 wk of gestation was associated with an increased risk of preeclampsia. The reason for the difference between the study by Cotter et al (153,156) and the other studies (149,151,152,157,160) is unknown. For data analyses, it is essential to consider when plasma tHcy was measured during gestation (138).…”

Section: Preeclampsiamentioning

confidence: 82%

“…Of these studies, all but 5 indicated that plasma tHcy in women with preeclampsia was significantly higher than in women without. In 4 of the 5 studies that found no association, tHcy was measured before 27 wk of gestation (149,152,157,160); in the fifth study, it was measured long after delivery (151). These findings may suggest that plasma tHcy is not elevated before clinical signs of preeclampsia appear, but that it increases considerably once signs develop.…”

Section: Preeclampsiamentioning

confidence: 98%

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Folate and human reproduction

Tamura

Picciano

2006

The American Journal of Clinical Nutrition

424

319

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The influence of folate nutritional status on various pregnancy outcomes has long been recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal folic acid supplementation as a means to prevent pregnancy-induced megaloblastic anemia. In the 1990s, the utility of periconceptional folic acid supplementation and folic acid food fortification emerged when they were proven to prevent the occurrence of neural tube defects. These distinctively different uses of folic acid may well be ranked among the most significant public health measures for the prevention of pregnancy-related disorders. Folate is now viewed not only as a nutrient needed to prevent megaloblastic anemia in pregnancy but also as a vitamin essential for reproductive health. This review focuses on the relation between various outcomes of human reproduction (ie, pregnancy, lactation, and male reproduction) and folate nutrition and metabolism, homocysteine metabolism, and polymorphisms of genes that encode folate-related enzymes or proteins, and we identify issues for future research.

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Section: Preeclampsiamentioning

confidence: 82%

Section: Preeclampsiamentioning

confidence: 98%

Folate and human reproduction

Tamura

Picciano

2006

The American Journal of Clinical Nutrition

424

319

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“…Recent reports have suggested an association of preeclampsia and HELLPsyndrome with hereditaryrisk factorsfor thrombophilia(2-4). However, the issue remains controversial (5)(6)(7)(8). In the present case, laboratoryt ests for thrombophilia showed normal activities of antithrombin, protein C, and protein S, and no evidenceoflupus anticoagulants.…”

Section: Thrombhaemost 2005; 93: 787-8mentioning

confidence: 52%

HELLP syndrome with fetal growth retardation in a woman homozygous for the prothrombin gene variant 20210A

Moessmer

Müller²,

Kolben³

et al. 2005

Thromb Haemost

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“…9 More recently, D'Aniello et al reported that a family history of hypertensive disorders was more prevalent in women who had poor pregnancy outcome and severe pre-eclampsia. 14 In our retrospective study that excluded women with diabetes, 8 a greater incidence of familial hypertension was reported by women with pre-eclampsia (65%) compared with normotensive women (35%; P < 0.01, Chi-squared). Women with pre-eclampsia more commonly reported that their mother or both parents had high blood pressure (34%) compared with the normotensive pregnant group (11.4%; P < 0.01).…”

Section: Familial Factors Predisposing To Pre-eclampsiamentioning

confidence: 72%

“…In a multivariate analysis of risk factors for pre‐eclampsia, a family history of hypertension was a strong predictor of the development of pre‐eclampsia 9 . More recently, D’Aniello et al reported that a family history of hypertensive disorders was more prevalent in women who had poor pregnancy outcome and severe pre‐eclampsia 14 . In our retrospective study that excluded women with diabetes, 8 a greater incidence of familial hypertension was reported by women with pre‐eclampsia (65%) compared with normotensive women (35%; P < 0.01, Chi‐squared).…”

Section: Familial Factors Predisposing To Pre‐eclampsiamentioning

confidence: 99%

Pre‐eclampsia: Contribution of Maternal Constitutional Factors and the Consequences for Cardiovascular Health

Barden

2006

Clin Exp Pharma Physio

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1. Pre-eclampsia is a serious complication of pregnancy that is potentially life threatening for both the mother and baby. It encompasses a number of abnormalities that may be present in other clinical conditions. 2. A placenta is essential for the development of pre-eclampsia and can be important in the pathogenesis of pre-eclampsia. Normal pregnancy is associated with remodelling of the maternal spiral arteries, which deliver blood to the placental villous space. Remodelling involves invasion by placental cytotrophoblasts that cause the maternal spiral arteries to lose their smooth muscle and become capacitance vessels; this process, known as placentation, is complete by 20 weeks of pregnancy. Poor placentation is associated with small-for-gestational-age fetuses and some cases of pre-eclampsia. It is thought that poor placentation can result in a hypoxic placenta that releases 'toxic substances' into the maternal circulation, contributing to the maternal syndrome. A number of candidate 'toxic substances' have been proposed, but none is universally raised in pre-eclampsia. 3. Although the placenta is necessary for the development of pre-eclampsia, the extent to which placental abnormalities contribute to the condition varies. It is becoming apparent that maternal constitutional factors may also be important in this syndrome. Underlying hypertension, diabetes and obesity strongly predispose to pre-eclampsia. However, a continuum of risk may exist for blood pressure, bodyweight, glucose and lipids, which, in combination with each other and some degree of placental abnormalities, may lead to the development of pre-eclampsia. 4. The present review will focus on the maternal constitutional factors that define the metabolic syndrome and examine their contribution to pre-eclampsia and the long-term consequences for cardiovascular health.

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The search for thrombophilic gene mutations in women with gestational hypertension does not help in predicting poor pregnancy outcome

Abstract: Only Factor II:C activity levels, uterine arterial Doppler and a history of familial hypertension are useful in predicting poor pregnancy outcome in gestational hypertension.

Cited by 13 publications

References 26 publications

Folate and human reproduction

Folate and human reproduction

HELLP syndrome with fetal growth retardation in a woman homozygous for the prothrombin gene variant 20210A

Pre‐eclampsia: Contribution of Maternal Constitutional Factors and the Consequences for Cardiovascular Health

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