The Seasonal Variations of the Chemical Composition of Essential Oil Obtained From Scrophularia frigida

Asgharian, Parina; Afshar, Fariba Heshmati; Asnaashari, Solmaz; Moghaddam, Sedigheh Bamdad; Delazar, Abbas

doi:10.17795/jjnpp-29742

Cited by 10 publications

(11 citation statements)

References 17 publications

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“…Seasonal variation for the essential oil of Scrophularia frigida Boiss. was compared and the essential oil of autumn sample was found to be composed of fatty acid derivatives mainly, while the essential oil of summer sample contained oxygenated monoterpenes as the major constituents [13]. Chemical composition of the essential oil of Scrophularia amplexicaulis Benth., which is a native species to Turkey, was also investigated by GC-FID/MS and the main constituents were found to be eugenol (53.8%) and eugenol acetate (24.5%) [14].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antimicrobial Activity of the Essential Oils of Five Scrophularia L. Species from Turkey

Renda¹,

Kalaycı²,

Korkmaz³

et al. 2017

Rec.Nat.Prod.

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The essential oils of the five Scrophularia species; Scrophularia chrysantha Jaub. et Spach, Scrophularia kotschyana Benth., Scrophularia olympica Boiss., Scrophularia cinerascens Boiss. and Scrophularia zuvandica Grossh. were obtained by hydrodistillation (HD) with a range of 0.10% to 0.16% yield and analazsed by GC-FID/MS. In the meantime, the volatile organic compounds (VOCs) of S. chrysantha, S. kotschyana, S. olympica, S. cinerascens and S. zuvandica were also identified with the technique of SPME GC-FID/MS and the phytochemical results were evaluated. The experimental results of this study showed that the major compounds of essential oils which were taken by the hydrodistillation were carvacrol (52.4%), 2pentadecanone (26.7%), 2-pentadecanone (12.2%), (Z)-2-nonenal (11.2%) and carvacrol (69.1%) respectively. Isovaleraldehyde (37.1%, 27.9%), eucalyptol (13.8%), 2-ethyl furan (14.8%) and 3(Z)-hexenol (91.3%) were respectively found as the main constituents of the five Scrophularia species with SPME method. Also antimicrobial activities of the essential oils of the five Scrophularia species were screened by using agar well diffusion method. It was identified that S. olympica, S.chrysantha, and S. kotschyana, have anti-tuberculosis activity, whereas, the essential oils gained from S. zuvandica and S. cinerascens have anti-fungal activity.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antimicrobial Activity of the Essential Oils of Five Scrophularia L. Species from Turkey

Renda¹,

Kalaycı²,

Korkmaz³

et al. 2017

Rec.Nat.Prod.

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“…1) and eugenol (1.3%) [23]. The main constituents of S. frigida essential oil were palmitic acid (30.49%), phytol (12.9%), L-linalool (11.41%) and hexahydrofarnesyl acetone (6.65%) [24], indicating that these compounds vary depending on the location of the plant collection, which can be caused by factors such as environmental conditions and plant genotypes, explaining the differences in the chemical composi-tion of these plants. The major chemical compounds isolated and identified from S. striata are cinnamic acid, some flavonoids such as quercetin, isorhamnetin-3-O-rutinoside, nepitrin and a glycoside (octreotide 1).…”

Section: Discussionmentioning

confidence: 99%

Study of extraction and chemical compounds of Scrophularia striata Boiss. and Scrophularia deserti Delile using HS-SPME and GC-MS

Bahmani

Hadavi

Abbasi

2020

Plant Biotechnol Persa

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In this study, from June 2019 to May 2019 aerial parts of Scrophularia striata Boiss. were collected from Ilam city and those of Scrophularia deserti Delile from Dehloran city, Ilam province in western Iran. The aerial parts of the medicinal plants were pulverized. The essential and volatile oils were extracted by headspace solid-phase microextraction (HS-SPME) and their chemical compounds analyzed by Gas chromatography-mass spectrometry (GC-MS). Using HS-SPME, 68 and 49 chemical compounds were identified from S. striata and S. deserti, respectively. Spathulenol (18.41%) was the highest chemical compound of the essential oil of S. striata, followed by caryophyllene oxide (15.38%), linalool (11.85%), alpha-terpineol (8.34%), trans-caryophyllene (4.44%) and geraniol (3.10%). The most important identified compounds from S. deserti were caryophyllene oxide (15.38%), linalool (11.85%), alpha-terpineol (8.34%), trans-caryophyllene (4.44%) and geraniol (3.10%). The most important chemical compounds of S. deserti essential oil included alpha-pinene (25.54%), alpha-phellandrene (19.60%), beta-myrcene (11.29%) and trans-caryophyllene (6.78%). Results show major constituents of this two plant include with a high amount of Spathulenol and caryophyllene oxide has high pharmaceutical and healthful value.

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“…Among natural products, medicinal herbs have played a vital role both in prophylaxis and treatment of various forms of malignancies. Scrophularia genus (Scrophulariaceae) encompasses over 3000 species which are extensively dispensed from mid Asia including Iran to North America (78910). Scrophularia subaphylla (S. subaphylla) is a well-known endemic medicinal species of Azerbaijan flora in Iran.…”

Section: Introductionmentioning

confidence: 99%

“…Scrophularia subaphylla (S. subaphylla) is a well-known endemic medicinal species of Azerbaijan flora in Iran. Traditionally, some species of this genus have been ethno medically consumed as anti-inflammatory, anti-eczema, anti-erythema, removing mouth dryness, improving sore throat, and anticancer agents (89). Numerous investigators have isolated some chemical constituents like iridoid glycosides, phenyl propanoids, flavonoids, terpenoids, and saponins from Scrophuria umbrosa (1112).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and antiproliferative activity of the aerial parts of Scrophularia subaphylla

et al. 2019

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Scrophularia subaphylla ( S. subaphylla ) L., a medicinal plant from the Scrophulariaceae family, has been reported to possess potential profits in the treatment and prophylaxis of different diseases. Some phenolic compounds in this genus have been displayed decent effects on different types of cancer via multiple mechanisms. The current study aimed to bioassay guided isolation of cytotoxic constituents from the aerial parts of S. subaphylla against breast (MCF-7) and colon (HT-29) cancer cell lines as well as normal cells (L929). Different extracts of S. subaphylla were acquired by Soxhlet apparatus and then subjected to brine shrimp lethality test and MTT assay for assessing their cytotoxic characteristics. Cytotoxic extract subjected to further phytochemical fractionation using solid phase extraction, reversed-phase high pressure liquid chromatography (RP-HPLC), and one dimensional nuclear magnetic resonance (1D-NMR) spectroscopy. The biological activity of the isolated pure components, verbascoside and 3‘ O rhamnosyl -4‘ O para coumaryl 7- hydroxyl salidroside , was assessed using MTT assay against MCF-7 and HT-29 carcinoma cells. Two known phenylpropanoid compounds were isolated from this species. Their structures were elucidated by spectroscopic data (using 1 H-NMR and 13 C-NMR) and compared with the previous literature. Both pure compounds in comparison with control group demonstrated significant antiproliferative activity against cancerous cells ( P < 0.001). In our study, verbascoside and its derivative could inhibit proliferation of cancerous cells without any side effects on normal cells.

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The Seasonal Variations of the Chemical Composition of Essential Oil Obtained From Scrophularia frigida

Cited by 10 publications

References 17 publications

Chemical Composition and Antimicrobial Activity of the Essential Oils of Five Scrophularia L. Species from Turkey

Chemical Composition and Antimicrobial Activity of the Essential Oils of Five Scrophularia L. Species from Turkey

Study of extraction and chemical compounds of Scrophularia striata Boiss. and Scrophularia deserti Delile using HS-SPME and GC-MS

Phytochemical analysis and antiproliferative activity of the aerial parts of Scrophularia subaphylla

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