The second nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan

Ohnishi, Takamitsu; Watanabe, Shinichi; Matsumoto, Tetsuya; Yotsuyanagi, Hiroshi; Sato, Junko; Kobayashi, Intestu; Iinuma, Shin; Nagayama, Takashi; Shibuya, Shuichiro; Ogawa, Natsuki; Iozumi, Ken; Nakajima, Yasuyuki; Kurikawa, Yukiko; Kobayashi, Mari; Matsuo, Koma; Ishikawa, Hideyuki; Shimizu, Tadamichi; Tsutsui, Kiyohiro; Kawamura, Tatsuyoshi; Okuyama, Ryuhei; Seishima, Mariko; Akita, Yoichi; Kasugai, Chikatoshi; Yano, Katsuaki; Tamada, Yasuhiko; Mizutani, Kimihiko; Kabashima, Kenji; Yamada, Nanako; Ikeda, Masami

doi:10.1016/j.jiac.2022.10.005

Cited by 3 publications

(6 citation statements)

References 6 publications

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“…The most frequent pathogens were methicillin-susceptible Staphylococcus aureus (MSSA). One striking finding was that the frequency of MRSA was similar between in-patients and out-patients, patients with and without history of antibiotic consumption the last 4 weeks and patients with and without history of hospitalization the last 1 year [3]. cSSTIs remain a major cause of healthcare-associated infections (HCAI).…”

Section: Trends In Epidemiologymentioning

confidence: 99%

Clinical evidence supporting ceftaroline fosamil and ceftobiprole for complicated skin and soft tissue infections

Leventogiannis

Mouktaroudi

Giamarellos‐Bourboulis

2023

Current Opinion in Infectious Diseases

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Purpose of reviewCeftaroline and ceftobiprole are advanced generation cephalosporins with activity against methicillinresistant Staphylococcus aureus (MRSA). This review summarizes their clinical efficacy for complicated skin and soft tissue infections (cSSTIs). Recent findingsBoth these agents retain excellent in vitro activity against both MRSA and Gram-negative isolates from patients with CSSTIs. Both these agents are registered for the management of cSSTIs based on the results of large scale phase III noninferiority trials. Ceftaroline and ceftobiprole are noninferior to the combination of vancomycin and aztreonam as this was assessed by their clinical cure rate at the test-of-cure visits. Furthermore, ceftobiprole is noninferior to comparators for the achievement of early clinical success at 72 h. Ceftaroline achieves 81% clinical cure against diabetic foot infections. SummaryCeftaroline and ceftobiprole can be used as monotherapy for the treatment of cSSTIs.

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Section: Trends In Epidemiologymentioning

confidence: 99%

Clinical evidence supporting ceftaroline fosamil and ceftobiprole for complicated skin and soft tissue infections

Leventogiannis

Mouktaroudi

Giamarellos‐Bourboulis

2023

Current Opinion in Infectious Diseases

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“…Though the aforementioned pathogens are usually susceptible to first-line antimicrobial agents in CA cases, several issues related to bacterial resistance may complicate the management of patients with SSTI, especially those with healthcare-associated (HA) diseases such as surgical wound infection (SWI) or super-infection of chronic ulcers [1,2 ▪ ]. In this latter situation, HA methicillin-resistant S. aureus (HA-MRSA) remains the most frequently encountered MDRB [12,13 ▪ ,20,21]; however, Pseudomonas aeruginosa and Acinetobacter baumannii (including MDR isolates), extended-spectrum-β-lactamase-producing and carbapenemase-producing Enterobacterales, vancomycin-resistant Enterococcus faecium and MR coagulase-negative staphylococci are commonly involved in healthcare settings with endemicity or on-going outbreaks [1]. Patients with prior exposure to broad-spectrum antimicrobials, recent and/or prolonged hospital stay, intensive care unit (ICU) admission, invasive procedures, chronic hemodialysis and long-term nursing care are especially at-risk for HA-SSTI due to MDRB.…”

Section: Diversity Of Pathogens Responsible For Moderate-to-severe Sk...mentioning

confidence: 99%

Rapid diagnostics for skin and soft tissue infections: the current landscape and future potential

Barbier

Woerther

Timsit

2023

Current Opinion in Infectious Diseases

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Purpose of reviewManaging antimicrobial therapy in patients with complicated skin and soft tissue infections (SSTI) constitutes a growing challenge due to the wide spectrum of potential pathogens and resistance phenotypes. Today, microbiological documentation relies on cultural methods. This review summarizes the available evidence regarding the clinical input of rapid microbiological diagnostic tools (RMDT) and their impact on the management of antimicrobial therapy in SSTI.Recent findingsAccurate tools are already available for the early detection of methicillin-resistant Staphylococcus aureus (MRSA) in SSTI samples and may help avoiding or shortening empirical anti-MRSA coverage. Further research is necessary to develop and evaluate RMDT detecting group A streptococci (e.g., antigenic test) and Gram-negative pathogens (e.g., multiplex PCR assays), including through point-of-care utilization. Next-generation sequencing (NGS) methods could provide pivotal information for the stewardship of antimicrobial therapy, especially in case of polymicrobial or fungal SSTI and in the immunocompromised host; however, a shortening in the turnaround time and prospective data regarding their therapeutic input are needed to better appraise the clinical positioning of these promising approaches.SummaryThe clinical input of RMDT in SSTI is currently limited due to the scarcity of available dedicated assays and the polymicrobial feature of certain cases. NGS appears as a relevant tool but requires further developments before its implementation in routine clinical practice.

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“…This is most likely due to evolution of pathogens associated with environmental changes, as well as the volume of antimicrobial use in the areas to control infections in humans and animals. The inappropriate use of antimicrobial agents can cause antimicrobial resistance [2,3].The spectrum of clinical manifestations in patients with SSTIs may range from cellulitis, folliculitis, erysipelas, and abscesses, including large furuncles and carbuncles. The clinical spectrum of the SSTIs can range from mild to severe, including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis [4].Definite diagnosis of pathogens causing SSTIs is necessary for an appropriate choice of antimicrobial regimens.…”

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Continuous monitoring of trends in pathogen and susceptibility profiles in patients with skin and soft tissue infections (SSTIs)

2023

Asian Biomedicine

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The skin is colonized by a diverse collection of microorganisms. Most microorganisms coexist with their human hosts without any complications. However, in many conditions, such as impaired host immunity and presence of virulent pathogens, skin and soft tissue infections (SSTIs) can occur [1].The most common organisms associated with SSTIs are bacteria, but other organisms such as fungi, viruses, Mycobacterium tuberculosis, and protozoa may occur [1]. The profile of predominant pathogens may vary based on geographical regions. This is most likely due to evolution of pathogens associated with environmental changes, as well as the volume of antimicrobial use in the areas to control infections in humans and animals. The inappropriate use of antimicrobial agents can cause antimicrobial resistance [2,3].The spectrum of clinical manifestations in patients with SSTIs may range from cellulitis, folliculitis, erysipelas, and abscesses, including large furuncles and carbuncles. The clinical spectrum of the SSTIs can range from mild to severe, including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis [4].Definite diagnosis of pathogens causing SSTIs is necessary for an appropriate choice of antimicrobial regimens. Definite diagnosis will require the isolation of pathogens via cultures of the skin lesions, biopsy with adequate tissues, and blood culture, among others. Isolated pathogens can be identified through specific microbiological analytic techniques such as special stains, molecular techniques, and antigen detection methodologies [1]. Immunocompromised hosts such as patients with immunodeficiencies, HIVs, cancers, and other clinical conditions can pose special diagnostic and therapeutic challenges [1].Removal of pus and necrotic tissue from the source of infection is needed. The choice of initial treatment depends on the epidemiological trends (community-or hospital-acquired infections), pathogen or pathogens involved, the virulence

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The second nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan

Cited by 3 publications

References 6 publications

Clinical evidence supporting ceftaroline fosamil and ceftobiprole for complicated skin and soft tissue infections

Clinical evidence supporting ceftaroline fosamil and ceftobiprole for complicated skin and soft tissue infections

Rapid diagnostics for skin and soft tissue infections: the current landscape and future potential

Continuous monitoring of trends in pathogen and susceptibility profiles in patients with skin and soft tissue infections (SSTIs)

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