The second wave of desaturation in coronavirus disease 2019

Alghizzawi, Mohd Islam; Ata, Fateen; Yousaf, Zohaib; AlHiyari, Mousa A; Bilal, Ammara Bint I; Elhiday, Abdelhaleem; Abdulhadi, Ahmad Salih

doi:10.1016/j.nmni.2021.100866

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…These mediators, in turn, stimulates the proliferation of type 2 alveolar cells and increases the recruitment of fibroblasts. Eventually, the cascade can lead to an increased production and storage of extracellular matrix (ECM), compromising the architecture of alveolar-capillary membrane leading to impaired gas exchange and hypoxemia (Vietri et al, 2019;Alghizzawi et al, 2021). These assumptions are confirmed by Yu MX, et al, that, by exploiting data mining and network pharmacology, showed that the molecular mechanisms of PF secondary to COVID-19 are mainly related to the TNF signaling pathway, the cytokine-cytokine receptor interaction pathway and the NF-κB signaling pathway.…”

Section: Cytokine Pathways and Development Of Fibrosismentioning

confidence: 99%

Common Molecular Pathways Between Post-COVID19 Syndrome and Lung Fibrosis: A Scoping Review

et al. 2022

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The pathogenetic mechanism of post-Covid-19 pulmonary fibrosis is currently a topic of intense research interest, but still largely unexplored. The aim of this work was to carry out a systematic exploratory search of the literature (Scoping review) to identify and systematize the main pathogenetic mechanisms that are believed to be involved in this phenomenon, in order to highlight the same molecular aspect of the lung. These aims could be essential in the future for therapeutic management. We identified all primary studies involving in post COVID19 syndrome with pulmonary fibrosis as a primary endpoint by performing data searches in various systematic review databases. Two reviewers independently reviewed all abstracts (398) and full text data. The quality of study has been assess through SANRA protocol. A total of 32 studies involving were included, included the possible involvement of inflammatory cytokines, concerned the renin-angiotensin system, the potential role of galectin-3, epithelial injuries in fibrosis, alveolar type 2 involvement, Neutrophil extracellular traps (NETs) and the others implied other specific aspects (relationship with clinical and mechanical factors, epithelial transition mesenchymal, TGF-β signaling pathway, midkine, caspase and macrophages, genetics). In most cases, these were narrative reviews or letters to the editor, except for 10 articles, which presented original data, albeit sometimes in experimental models. From the development of these researches, progress in the knowledge of the phenomenon and hopefully in its prevention and therapy may originate.

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Section: Cytokine Pathways and Development Of Fibrosismentioning

confidence: 99%

Common Molecular Pathways Between Post-COVID19 Syndrome and Lung Fibrosis: A Scoping Review

et al. 2022

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COVID 19 Second Wave – What Has Changed Since the First Wave

Ragunathan

Nazer

Bharathi

et al. 2022

CHRISMED Journal of Health and Research

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A pandemic named SARS-COV2 COVID 19 affected many people's life in different ways globally. The normal life is still far away, lockdown rules have been relaxed in many countries. Morbidity and mortality increased a lot after the first wave. COVID-19 has affected medical education in a significant way. Most of the patients were asymptomatic during the second wave and some had symptoms such as myalgia, fever, and cough, which complicated to pneumonia, respiratory distress, and thromboembolic complications. There have been the development of many vaccines such as Covaxin, Pfizer–BioNTech, Covishield, Sputnik V, and Moderna, and these vaccinations have been given to frontline medical workers, people with comorbidities, aged people, etc., with high priority and then the general population. Many pregnant and peripartum women were put on Extracorporeal Membrane Oxygenation (ECMO) in severe to critical cases. A new black fungus was found in post-COVID 19 infections. It was named mucormycosis which usually affected immunocompromised people. There is a high importance in the examination of all the different epidemiological variables of all the places in all the regions across the world, to understand the mutations, and severity of the disease and also to be prepared. Many studies done on COVID-19 in first and the second wave was reviewed in detail and were compared for this review.

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The second wave of desaturation in coronavirus disease 2019

Cited by 2 publications

References 13 publications

Common Molecular Pathways Between Post-COVID19 Syndrome and Lung Fibrosis: A Scoping Review

Common Molecular Pathways Between Post-COVID19 Syndrome and Lung Fibrosis: A Scoping Review

COVID 19 Second Wave – What Has Changed Since the First Wave

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