The secret life of steroids in asthma

Sterk, Peter J.; Yick, Ching Yong; Slats, Annelies M.

doi:10.1183/09031936.00135508

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…However, it is unclear whether these benefits are based solely on antiinflammatory properties or whether glucocorticoids also exert other local actions within the airways (10). In vitro studies suggest that glucocorticoids may change gene transcription in ASM cells (11), leading to altered transcription of contractile elements, cytoskeleton, cell surface molecules, cytokines, and mediators (12).…”

mentioning

confidence: 98%

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

Yick¹,

Zwinderman²,

Kunst

et al. 2013

Am J Respir Crit Care Med

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confidence: 98%

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

Yick¹,

Zwinderman²,

Kunst

et al. 2013

Am J Respir Crit Care Med

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“…2,3 More asthma pharmacogenomics studies are needed 4,5 as the exact mechanism of the antiasthmatic effect of ICSs is still unknown; particularly, it is not clear if their anti-inflammatory effect is crucial for successful asthma treatment. 6 More than 100 genes have been linked with asthma in numerous association studies, but these are usually not confirmed in different populations or age groups. 7 The first genome-wide association study in asthma, performed by Moffatt et al, 8 identified single-nucleotide polymorphisms (SNPs) in the noncoding part or near the ORM1-like protein 3 (ORMDL3) gene at locus 17q21 that confer an increased risk of childhood asthma and influence ORMDL3 and adjacent gasdermin B (GSDMB) gene expression.…”

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confidence: 99%

Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma

2012

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Recent genome-wide association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome 17q21. We analyzed the effect of functional SNP rs2872507 in ORMDL3 gene region on the response to antiasthmatic treatment with inhaled corticosteroids (ICSs) and ORMDL3 gene expression. Forced expiratory volume in 1 s increased significantly by 13.3% of predicted value after therapy in atopic asthmatics with AA genotype, compared with 7.0% in heterozygotes and 4.9% increase in GG homozygotes (P=0.0176). Median relative expression of ORMDL3 gene in asthmatics with AA, AG and GG genotypes was 0.75, 1.05 and 1.21, respectively (P<0.0001). Treatment with ICSs was significantly associated with the increase of median relative expression of ORMDL3 gene, from 0.88 to 1.21 (P=0.0032) in atopic asthmatics. Our results suggest that rs2872507 is associated with ORMDL3 gene expression and with ICS treatment response in children with atopic asthma.

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The secret life of steroids in asthma

Cited by 2 publications

References 29 publications

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma

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