Background: The infant contracted Herpes Simplex Virus (HSV) during the process of being born. The worldwide occurrence of NH is approximately 10 cases per 100,000 births, and it is associated with substantial risks of illness and death. Objective: To evaluate nurses' level of understanding regarding HHV-6 infection in the neonatal intensive care unit (NICU) for newborn infants. The study employed a descriptive research design methodology to achieve its objective. A representative sample of 50 nurses currently employed in neonatal critical care units. Tool I: An Arabic-language structured interview questionnaire. The study encompassed many demographic factors of nurses, such as gender, age, educational attainment, years of experience in the Neonatal Intensive Care Unit (NICU), completion of training on HHV-6 infection, and the source of information. The second tool, the knowledge assessment sheet, focused on HHV-6 infection. The findings indicate that the study included exclusively female nurses, comprising 46.0% of the sample, while males accounted for 54%. Furthermore, the educational background of the participants primarily consisted of graduates from nursing institutes and colleges, with each group representing a substantial proportion of 34%. Conclusion: Our findings indicate that we have chosen to dismiss the null hypothesis, which posits that there is no correlation between the demographic attributes of nurses and their degree of understanding regarding herpes virus type 6 infection. Instead, we have opted to embrace the alternative hypothesis. Recommendations: Provide nurses with a thorough knowledge of the viral causes and risk factors linked to HSV type 6 infections in pregnant women.
