The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells

Rittig, Kilian; Dolderer, J.; Balletshofer, Bernd; Machann, Jürgen; Schick, Fritz; Meile, Tobias; Küper, Markus A.; Stock, Ulrich A.; Staiger, Harald; Machicao, Fausto; Schaller, H.-E.; Königsrainer, Alfred; Häring, Hans‐Ulrich; Siegel-Axel, Dorothea

doi:10.1007/s00125-012-2481-9

Cited by 72 publications

(63 citation statements)

References 47 publications

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“…Of note, previous studies could show that new vessel formation contributes to atherosclerotic lesion growth by enhancing inflammatory cell recruitment [32]. Our observations extend previous data that primary human fat cells isolated from PVAT released high amounts of angiogenic factors [48], and that conditioned medium from perivascular adipocytes strongly enhanced endothelial cell tubulogenesis/angiogenesis [38].…”

Section: Discussionsupporting

confidence: 87%

Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis

et al. 2016

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Section: Discussionsupporting

confidence: 87%

Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis

et al. 2016

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“…Furthermore, due the importance of adipose tissue in IR, adipose-derived HGF expression might also have an influence on the obesity associated IR etiology. In fact, a recent study examined HGF secretion in different types of adipose tissue and observed that the HGF secretion pattern of the perivascular adipose tissue differs from the subcutaneous and visceral adipocytes (26). Surprisingly, this research also showed that, in both in vitro and in vivo models, perivascular fat cells have a much higher capacity for secreting adipokines, especially HGF, than other fat cell types.…”

Section: Role Of Adipose Tissue Derived Hgfmentioning

confidence: 99%

The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes

et al. 2018

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In obesity, insulin resistance (IR) and diabetes, there are proteins and hormones that may lead to the discovery of promising biomarkers and treatments for these metabolic disorders. For example, these molecules may impair the insulin signaling pathway or provide protection against IR. Thus, identifying proteins that are upregulated in IR states is relevant to the diagnosis and treatment of the associated disorders. It is becoming clear that hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in β-cell homeostasis; and is capable of modulating the inflammatory response. In this review, we discuss how, and to what extent HGF contributes to IR and diabetes pathophysiology, as well as its role in cancer which is more prevalent in obesity and diabetes. Based on the current literature and knowledge, it is clear that HGF plays a central role in these metabolic disorders. Thus, HGF levels could be employed as a biomarker for disease status/progression, and HGF/c-Met signaling pathway modulators could effectively regulate IR and treat diabetes.

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“…39 HGF is preferentially released by PVAT cells and stimulates endothelial cell growth and cytokine release from SMCs. Interestingly, only the PVAT mass, not the visceral or subcutaneous mass, correlates independently with serum HGF levels in patients, 39 implying that PVATderived HGF is important to vascular remodeling. In summary, higher levels of both angiogenic factors, such as HGF, and inflammation in PVAT may have pathological relevance, and may contribute to atherosclerotic plaque complications (Figure).…”

mentioning

confidence: 97%

Paradoxical Roles of Perivascular Adipose Tissue in Atherosclerosis and Hypertension

Chang

Hamblin

Eitzman

et al. 2013

Circ J

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Perivascular adipose tissue (PVAT) is the fat tissue surrounding most of the vasculature and it has long been considered solely as vessel-supporting connective tissue. There are 2 major types of adipose tissue widely distributed throughout the body: white (WAT) and brown (BAT). PVAT is similar to BAT in rodents, but it was believed that only WAT existed in adult humans and BAT was present only in infants. However, the presence of functional BAT in adult humans is now accepted. The main function of BAT is to generate heat, and it is essential for adaptive thermogenesis and energy expenditure, whereas the main function of WAT is to store lipids. Besides the different functions of WAT and BAT, growing evidence suggests that different depots of adipose tissue have different functions. Similar to other fat depots, PVAT produces various adipokines, growth factors and inhibitors that affect functions of adjacent layers of the vasculature. Pathophysiological conditions such as obesity, vascular injury, aging and infection could cause PVAT dysfunction, leading to vascular endothelial and smooth muscle cell dysfunctions. In this review, we discuss the function and dysfunction of PVAT on atherosclerosis and hypertension.

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The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells

Cited by 72 publications

References 47 publications

Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis

Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis

The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes

Paradoxical Roles of Perivascular Adipose Tissue in Atherosclerosis and Hypertension

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