The Secretory IgA System

Hanson, L A; Åndersson, Bengt; Carlsson, B.; Dahlgren, U.; Mellander, Lotta; Porras, Óscar; Edén, C. Svanborg; Söderström, T

doi:10.1055/s-2008-1033997

Cited by 14 publications

(12 citation statements)

References 25 publications

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“…Transmission of developmental messages is thought to be promoted through the actions of leukocytes, hormones, growth factors and cytokines, and the other milk components themselves (e.g., oligosaccharides and lactoferrin) present in abundance in human milk [43,61,[80][81][82][83]. Further, there is increasing evidence to suggest that early nutrition acts via epigenetic mechanisms to achieve "metabolic imprinting" and that this is an adaptive response to the extrauterine environment with lifelong health implications [84][85][86].…”

Section: Transitioning From Amniotic Fluid To Human Milkmentioning

confidence: 99%

“…Perhaps the best known aspect of human milk is its ability to provide passive immunity to the infant through its secretory IgA, greatest in colostrum but still present in significant concentrations throughout lactation [82,83,161]. This passive immunity is an extension of the transplacental transfer of maternal IgG to the fetus, with levels of IgG in the neonate nearing 90% of maternal levels at term [162].…”

Section: Immunologic Aspects Of Human Milkmentioning

confidence: 99%

“…Whereas sIgA functions to stop microbes along the GI tract to prevent infection and invasion, transplacental IgG antibodies act in tissues and induce inflammation and as such are energy consuming [157]. The mother as the mature, immunocompetent host who shares the same environment as her infant-with similar exposures to pathogens-responds to such mucosal barrier affronts with the production of sIgA that are specific to her infant and include pathogens that the neonate acquired during transit through the birth canal [80,82,83,157,161,162]. The lactogenic hormones produced during the end of pregnancy induce migration of lymphocytes from the Peyer's patches in the gut to the mammary gland via the lymph system.…”

Section: Immunologic Aspects Of Human Milkmentioning

confidence: 99%

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Host Factors in Amniotic Fluid and Breast Milk that Contribute to Gut Maturation

Wagner

Taylor

Johnson

2007

Clinic Rev Allerg Immunol

150

103

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The gut represents a complex organ system with regional differences, which reflect selective digestive and absorptive functions that change constantly in response to bodily requirements and the outside milieu. As a barrier to the external environment, gut epithelium must be renewed rapidly and repeatedly. Growth and renewal of gut epithelial cells is dependent on controlled cell stimulation and proliferation by a number of signaling processes and agents, including gut peptides-both endogenous and exogenous sources. This cascade of events begins during fetal development; with the ingestion of amniotic fluid, this process is enhanced and continued during infancy and early childhood through the ingestion of human milk. Events influenced by amniotic fluid during fetal development and those influenced by human milk that unfold after birth and early childhood to render the gut mature are presented.

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Section: Transitioning From Amniotic Fluid To Human Milkmentioning

confidence: 99%

Section: Immunologic Aspects Of Human Milkmentioning

confidence: 99%

Section: Immunologic Aspects Of Human Milkmentioning

confidence: 99%

See 1 more Smart Citation

Host Factors in Amniotic Fluid and Breast Milk that Contribute to Gut Maturation

Wagner

Taylor

Johnson

2007

Clinic Rev Allerg Immunol

150

103

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“…Durch Immunexklusion und/oder das Besetzen ökologischer Nischen werden das Anheften und die Invasion schädlicher Substanzen verhindert. Abhängig vom Aktivierungsgrad der intestinalen Plasmazellen lassen sich entsprechende sIgA-Mengen im Stuhl nachweisen und gestatten damit eine Aussage über den Zustand des darmassoziierten Immunsystems [19,20,24]. In der Literatur werden Indikationen und klinische Effekte der Fastentherapie beschrieben [12,27].…”

Section: Introductionunclassified

Verläufe des sekretorischen Immunglobulins A des Darms und Befindlichkeit von Patienten unter naturheilkundlicher Therapie und Heilfasten

Rüffer²,

Balles³

et al. 2001

Complement Med Res

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Change of the Secretory Immunoglobulin A and the Condition of the Patients during Naturopathic Therapy and Heal-Fasting Therapy Background: In clinical observations it was noticed that patients who have been treated with naturopathic methods – especially with the treatment of heal fasting – experience a stabilization of their immune system. The immune system stands in close relation to the intestinal flora and influences the condition of the patient. Question: For this reason the influence of a 3-week in-hospital naturopathic therapy – among others a heal-fasting therapy –, a corresponding follow-up on the intestine-associated immune system as well as the condition of the patients have been examined. Patients and Methods: Classical naturopathic treatments based on standardized therapy concepts were applied. The patients (n = 55) showed different kinds of basic diseases, whereof in 56% of the cases the patients suffered of diseases of the skeleton, the muscles, and the connective tissue. The patients got a 3-week standardized high-quality nutrition or they took part in a juice-modified fasting therapy. The state of the local endogenous defense system within the intestine was measured by the concentration of the secretory immunoglobulin A (sIgA) in the feces of the patients. A positive criterion was a sIgA concentration in the stool of under 0.5 mg/g. Additionally the judgement of the patients concerning their own condition (‘quality of life’) was determined by the condition scale. Results: It was shown that the content of the sIgA within the stool was increased during the course of the in-hospital stay, in the complete population of patients as well as in the different subgroups ‘with heal-fasting’ and ‘without heal-fasting’. Even in the follow-up analysis it could be observed that 3 months after the treatment the content of secretory IgA in the stool of all groups was between 0.78 and 0.89 mg/g. This value was significantly higher than the starting values. The most intensive effects concerning the change of sIgA were measured within the group of the patients who performed heal fasting (Ε > 1.0). Aside from the increase of the secretory IgA, a mediocre improvement of the condition of the patients within the pre-post comparison could be noticed, but no correlation between the secretory IgA values and the values concerning the condition was found. Conclusion: A 3-week in-hospital therapy with classical naturopathic treatments (but especially the application of the heal-fasting therapy) leads to a significant improvement of the immune condition of the intestine and consequently of the whole organism. The improving effect lasts beyond the stay in hospital.

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“…Secretory IgA (sIgA) plays an important role in the human immune system as a first line of defence against viral and bacterial infection. It is thought that synthesis of sIgA starts in early childhood [2]. Many authors report a progressive increase of sIgA levels in saliva during the first year of childhood [3][4][5][6], however some authors were unable to measure sIgA in saliva during the first 10 days after birth [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Determination of Secretory IgA and Albumin in Saliva of Newborn Infants

Seidel

Schulze²,

Kieß³

et al. 2000

Neonatology

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As a first line of defence against microbial invasion, secretory IgA (sIgA) is the dominant immunoglobulin on all mucosal surfaces. In this study sIgA was determined by radial immunodiffusion in saliva samples of 63 newborn infants divided into the following age groups: (1) 1 day and younger, (2) 2–10 days. Concentrations of sIgA and albumin as well as their relation to age, postprandial time, gestational age and birth weight were analysed. sIgA could be detected in 75.0% (group 1) and 77.1% (group 2) of the saliva samples with a mean concentration of 190.2 mg/l (group 1) and 216.4 mg/l (group 2). Differences failed to reach significance. Concentration of sIgA was found to be independent of age but positively related to the concentration of albumin in the same saliva sample. In conclusion, this study provides evidence that high levels of sIgA are found in saliva of newborn infants, indicating the existence of a competent oral mucosal immune system as early as within the first 10 days of life.

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The Secretory IgA System

Cited by 14 publications

References 25 publications

Host Factors in Amniotic Fluid and Breast Milk that Contribute to Gut Maturation

Host Factors in Amniotic Fluid and Breast Milk that Contribute to Gut Maturation

Verläufe des sekretorischen Immunglobulins A des Darms und Befindlichkeit von Patienten unter naturheilkundlicher Therapie und Heilfasten

Determination of Secretory IgA and Albumin in Saliva of Newborn Infants

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