The Securinega Alkaloids

Chirkin, Egor; Atkatlian, William; Porée, François‐Hugues

doi:10.1016/bs.alkal.2014.11.001

Cited by 41 publications

(59 citation statements)

References 119 publications

(280 reference statements)

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“…Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, has been reported to have potent biological activity and has been used clinically in several countries [11]. Securinine has been found to be an antagonist of the γ -amino butyric acid (GABA) A receptor and as such is currently used in the treatment of neurological conditions such as ALS, poliomyelitis, and multiple sclerosis [12–14].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Leonoudakis

Rane

Angeli

et al. 2017

Mediators of Inflammation

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Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson's disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target to alleviate neurodegeneration. Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, has been reported to have potent biological activity and is used in the treatment of neurological conditions such as amyotrophic lateral sclerosis, poliomyelitis, and multiple sclerosis. In this study, we explored the underlying mechanisms of neuroprotection elicited by securinine, particularly its anti-inflammatory effects in glial cells. Our results demonstrate that securinine significantly and dose-dependently suppressed the nitric oxide production in microglia and astrocytic cultures. In addition, securinine inhibited the activation of the inflammatory mediator NF-κB, as well as mitogen-activated protein kinases in lipopolysaccharide- (LPS-) stimulated BV2 cells. Additionally, securinine also inhibited interferon-γ- (IFN-γ-) induced nitric oxide levels and iNOS mRNA expression. Furthermore, conditioned media (CM) from securinine pretreated BV2 cells significantly reduced mesencephalic dopaminergic neurotoxicity compared with CM from LPS stimulated microglia. These findings suggest that securinine may be a potential candidate for the treatment of neurodegenerative diseases related to neuroinflammation.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Leonoudakis

Rane

Angeli

et al. 2017

Mediators of Inflammation

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“…1 Some of these plants have been used in traditional folk medicines across Asia, Africa and Amazonia, and subsequently, several compounds of the family were shown to exhibit antimalarial, antibacterial, antitumor as well as central nerve system activities. 1,2 Among the Securinega alkaloids, securinine constitutes the most abundant and best-studied representative featuring the securinane skeleton (Scheme 1A), and the group includes a series of isomeric neosecurinane-type and two lower homologs of norsecurinane-and neonorsecurinane-type, respectively (see Scheme 1A for an overview). Structurally, these compounds can be divided in groups featuring either azabicyclo[2.2.2]-or azabicyclo[3.2.1]octane BC ring systems with a fused pyrrolidine or piperidine ring.…”

mentioning

confidence: 99%

Investigating Biogenetic Hypotheses of the Securinega Alkaloids: Enantioselective Total Syntheses of Secu’amamine E/ent-Virosine A and Bubbialine

et al. 2017

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The synthesis of the Securinega alkaloid secu'amamine E (ent-virosine A) has been accomplished for the first time in 12 steps and 8.5% overall yield. In addition, bubbialine has been prepared and characterized. These two alkaloids and bubbialidine, all featuring an azabicyclo[2.2.2]octane core, were rearranged to their azabicyclo[3.2.1]octane congeners, a framework found in many Securinega alkaloids. These experiments suggest that azabicyclo[2.2.2]octane derivatives could serve as intermediates in the biosynthesis of the rearranged azabicyclo[3.2.1]octane products.

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“…Securinine alkaloids also exhibit various antimicrobial effects 190,191 . Mensah et al 50 identified two antibacterial securinine alkaloids from a water extract of Phyllunthus discoideus leaves as early as 1990.…”

Section: Bioactivities Of Indolizidine Alkaloidsmentioning

confidence: 99%

Biologically active indolizidine alkaloids

Zhang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

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Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of important biological activities. In this review, we discuss the biological activity and pharmacological effects of indolizidine alkaloids and offer new avenues toward the discovery of new and better drugs based on these naturally occurring compounds.

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The Securinega Alkaloids

Cited by 41 publications

References 119 publications

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Investigating Biogenetic Hypotheses of the Securinega Alkaloids: Enantioselective Total Syntheses of Secu’amamine E/ent-Virosine A and Bubbialine

Biologically active indolizidine alkaloids

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