The seed and soil hypothesis revisited: Current state of knowledge of inherited genes on prognosis in breast cancer

Ribelles, Nuria; Santonja, Ángela; Pajares, Bella; Llácer, Casilda; Alba, Emilio

doi:10.1016/j.ctrv.2013.09.010

Cited by 49 publications

(45 citation statements)

References 71 publications

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“…The differences between our study and other studies might be explained by the different source of biological material. In contrast to our study on tumor tissue, most results describing the metastatic ability of tumor cells have been performed [8,25,26]. The results from in vitro studies are not comparable with the data from tumor tissue, which is not as homogenic as a cell line [25,26].…”

Section: Discussioncontrasting

confidence: 79%

“…In contrast to our study on tumor tissue, most results describing the metastatic ability of tumor cells have been performed [8,25,26]. The results from in vitro studies are not comparable with the data from tumor tissue, which is not as homogenic as a cell line [25,26]. The results of the present study show that MMP-9 expression was significantly higher in patients with a high level of PR, and that there was a significant positive correlation between MMP-9 and PR, but not between MMP-9 and ER expression, as well as between MMP-2, ER, and PR in endometrial cancer.…”

Section: Discussionmentioning

confidence: 92%

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The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Gryboś

Bär

2014

Folia Histochem Cytobiol.

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Abstract:The role of the parallel expression of the KAI1 protein and metalloproteinases (MMP-2 and MMP-9) in respect to the status of steroid receptors in endometrial cancer is still incompletely understood. The aim of this study was to evaluate the expression of and correlation between KAI1 on one hand and MMP-2 and MMP-9 on the other hand in terms of the status of the estrogen (ER) and progesterone receptors (PR) in 100 patients with endometrial cancer. The expressions of KAI1, MMP-2, MMP-9, ER and PR were assessed immunohistochemically on paraffin-embedded tissues. No correlations were found between these biomarkers and the clinical and pathological parameters of the endometrial cancer. However, in KAI1-positive cases, the expression was limited to a small area of tumor tissue in FIGO stages III-IV. A tendency towards the high expression of MMP-9 and MMP-2 was observed in the advanced stages of endometrial cancer (FIGO IIIA-IV). Positive correlations between the presence of KAI1 and PR and between the presence of MMP-9 and PR were found in endometrial cancer. A positive correlation was also observed between KAI1 and MMP-2 expression, and a borderline one between KAI1 and MMP-9 expression in endometrial cancer. KAI1 -/MMP-2 + and KAI1 -/MMP-9 + phenotypes were more often observed in FIGO stage II. Our study showed that KAI1 protein, as well as steroid receptors, might modulate MMP-2 and MMP-9 expression in endometrial cancer. Our study revealed that the overlapping expression of the biomarkers investigated here suggests that cooperation between these molecules exists, even at the early stages of endometrial cancer growth, and may determine the speed of tumor cell dissemination and might characterize the biological behavior of endometrial cancer.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 92%

The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Gryboś

Bär

2014

Folia Histochem Cytobiol.

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“…24,25 “Seed and soil” theory is well acknowledged for bone metastases: circulating cancer cells (seeds) can accomplish metastasis in the organs, of which microenvironment (soil) is advantageous for their growth. 25,26 PVI was associated with cancer cell invasion from primary location, and was proven to be a high-risk predictor of the BMFS in our study (HR = 4.066, 95% CI 1.186–13.935, P = 0.026). Immobilized growth factors fertilized the bone marrow, including the transforming growth factor β (TGF-β), insulin-like growth factors (IGFs), fibroblast growth factors (FGFs), and platelet-derived growth factors (PDGFs).…”

Section: Discussionsupporting

confidence: 57%

Prognostic Value of Chemotherapy-Induced Neutropenia at the First Cycle in Invasive Breast Cancer

Chen²,

Zhang³

et al. 2016

Medicine

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Chemotherapy-induced neutropenia (CIN) was the most apparent side effects of bone marrow suppression with adjuvant chemotherapy. Recently, several studies revealed that CIN may predict better outcomes. However, the researches upon breast cancer were still indefinite.We reviewed the female patients with pathologically diagnosed invasive breast cancer at the First Affiliated Hospital of Wenzhou Medical University, between Jan 2008 and Dec 2010. The lowest neutrophil counts in the second week after the first cycle of chemotherapy were collected. Clinicopathological characteristics and survival rates were compared and analyzed between the CIN group and non-CIN group.The median follow-up time was 62 months. The differences of over-all survival and local recurrence-free survival between the 2 groups were nonsense (P = 0.938, P = 0.695, respectively). But the disease-free survival and distant metastasis-free survival of the CIN group were statically significantly better (HR = 0.391, P = 0.009, and HR = 0.315, P = 0.005, respectively). The bone metastasis-free survival may be responsible for the differences (HR = 0.469, P = 0.005). Subgroup analyses showed the CIN may predict lower bone metastases rates with ER positive status, premenopause or younger age (≤ 40) (P = 0.002, P = 0.004, and P = 0.0001, respectively). Cox analysis showed younger ages, N staging, and the presence of CIN were associated with bone metastasis-free survival independently adjusting to peritumoral vascular invasion (P < 0.05).CIN may predict a decreased recurrence risk of breast cancer, especially bone metastases.

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“…However, this pretreatment was inefficient on cells that had succeeded extravasation from the blood stream. The cells were able to soil [22] and develop metastases demonstrating that the pre-medication preferentially impacted on tumor cells before breaching blood vessels to enter the lung parenchymal tissue. When the cells were pre-incubated with the peptide, thereby blocking NRP1 cell–autonomous signaling pathways, we found both a reduction of the number and size of metastases.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide

et al. 2016

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The transmembrane domains (TMD) in membrane receptors play a key role in cell signaling. As previously shown by us a peptide targeting the TMD of neuropilin-1 (MTP-NRP1), blocks cell proliferation, cell migration and angiogenesis in vitro, and decreases glioblastoma growth in vivo. We now explored the clinical potential of MTP-NRP1 on breast cancer models and demonstrate that MTP-NRP1 blocks proliferation of several breast cancer lines including the MDA-MB-231, a triple negative human breast cancer cell line. In models with long term in vivo administration of the peptide, MTP-NRP1 not only reduced tumor volume but also decreased number and size of breast cancer metastases. Strikingly, treating mice before tumors developed protected from metastasis establishment/formation. Overall, our results report that targeting the TMD of NRP1 in breast cancer is a potent new strategy to fight against breast cancer and related metastasis.

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The seed and soil hypothesis revisited: Current state of knowledge of inherited genes on prognosis in breast cancer

Cited by 49 publications

References 71 publications

The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Prognostic Value of Chemotherapy-Induced Neutropenia at the First Cycle in Invasive Breast Cancer

Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide

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