2017
DOI: 10.1016/j.biocel.2017.01.007
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The selective cytotoxicity of DSF-Cu attributes to the biomechanical properties and cytoskeleton rearrangements in the normal and cancerous nasopharyngeal epithelial cells

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Cited by 22 publications
(13 citation statements)
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“…Previously, two studies indicated that DSF/Cu induces NPC cell apoptosis by increasing chloride channel-3 protein expression, or by inducing ROS production and decreasing NF-KB-p65 expression [36,37]. These studies, together with our findings, indicate that DSF/Cu induces anti-NPC activity through a joint action of multiple pathways.…”
Section: Discussionsupporting
confidence: 84%
“…Previously, two studies indicated that DSF/Cu induces NPC cell apoptosis by increasing chloride channel-3 protein expression, or by inducing ROS production and decreasing NF-KB-p65 expression [36,37]. These studies, together with our findings, indicate that DSF/Cu induces anti-NPC activity through a joint action of multiple pathways.…”
Section: Discussionsupporting
confidence: 84%
“…This actin polymer is filamentous actin (F-actin). The main functions of microfilaments are the formation of stress fibers, cell movement, and cytokinesis [ 15 ].…”
Section: Cytoskeletal Reorganization and Cancer Cell Movementmentioning
confidence: 99%
“…However, studies have shown that the DSF-Cu complex has an anti-tumor effect [ 109 ]. The stiffness and adhesion of nasopharyngeal carcinoma cells treated with DSF-Cu have been shown to be increased [ 110 ], which suggested that DSF-Cu reduces the deformability and enhances the adhesion of these cells. DSF-Cu may, therefore, inhibit the malignant growth and metastasis of nasopharyngeal carcinoma cells.…”
Section: Evaluation and Development Of Antitumor Drugsmentioning
confidence: 99%