The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats

Yamamotová, A; Pometlová, Marie; Harmatha, Juraj; Rašková, H; Rokyta, Richard

doi:10.1016/j.jep.2007.03.016

Cited by 15 publications

(6 citation statements)

References 26 publications

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“…It can be interpreted as follows; assuming relatively stable patter in nociception, acute dose of MA had a greater anxiolytic effect in individuals more sensitive to pain than in animals less sensitive to pain and the other way around. A similar relationship between nociception and anxiety was observed in rats after administration of N-feruloylserotonin (extracted from Leuzea carthamoides) which has been demonstrated anxiolytic effect (Yamamotová et al, 2007).…”

Section: Discussionsupporting

confidence: 56%

Can Anxiety Tested in the Elevated Plus-maze Be Related to Nociception Sensitivity in Adult Male Rats?

Pometlová¹,

Yamamotová²,

Nohejlová³

et al. 2016

Prague Med. Rep.

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Methamphetamine (MA) is one of the most addictive psychostimulant drugs with a high potential for abuse. Our previous studies demonstrated that MA administered to pregnant rats increases pain sensitivity and anxiety in their adult offspring and makes them more sensitive to acute administration of the same drug in adulthood. Because individuals can differ considerably in terms of behaviour and physiology, such as rats that do not belong in some characteristics (e.g. anxiety) to average, can be described as low-responders or high-responders, are then more or less sensitive to pain. Therefore, prenatally MA-exposed adult male rats treated in adulthood with a single dose of MA (1 mg/ml/kg) or saline (1 ml/kg) were tested in the present study. We examined the effect of acute MA treatment on: (1) the anxiety in the Elevated plus-maze (EPM) test and memory in EPM re-test; (2) nociception sensitivity in the Plantar test; (3) the correlation between the anxiety, memory and the nociception. Our results demonstrate that: (1) MA has an anxiogenic effect on animals prenatally exposed to the same drug in the EPM; (2) all the differences induced by acute MA treatment disappeared within the time of 48 hours; (3) there was no effect of MA on nociception per se, but MA induced higher anxiety in individuals less sensitive to pain than in animals more sensitive to pain. In conclusion, the present study demonstrates unique data showing association between anxiety and nociceptive sensitivity of prenatally MA-exposed rats that is induced by acute drug administration.

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Section: Discussionsupporting

confidence: 56%

Can Anxiety Tested in the Elevated Plus-maze Be Related to Nociception Sensitivity in Adult Male Rats?

Pometlová¹,

Yamamotová²,

Nohejlová³

et al. 2016

Prague Med. Rep.

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“…late proestrus and early estrus) also correspond to the lowest anxiety of female rats tested in an elevated plus‐maze (Marcondes et al, 2001). Moreover, we have recently shown that the time spent in the open arms of an elevated plus‐maze was inversely related to the latency of forelimbs in the plantar test (Yamamotová et al, 2007a,b), therefore decreased latencies in our METH and S female rats should also reflect reduced anxiety. Our data are also supported by observation of Pan and Chen (2007), who found in neonatal caffeine‐treated rats hyperalgesia in hot‐plate test and lower anxiety measured by time spent in open arms of elevated plus‐maze.…”

Section: Discussionmentioning

confidence: 75%

Perinatal effect of methamphetamine on nociception in adult Wistar rats

Yamamotová

Hrubá

Schutová

et al. 2010

Intl J of Devlp Neuroscience

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Methamphetamine is a psychostimulant drug which causes the release of monoamine neurotransmitters. Although drugs of abuse are known to have analgesic effects, there is a lack of evidence regarding the effect of prenatal exposure to methamphetamine on nociception in adulthood. Adult Wistar rats whose mothers had received daily exposure to methamphetamine (5 mg/kg; s.c.) or saline, during gestation or gestation and lactation periods, were examined for: (1) gender differences in nociception; (2) an association between nociception and gross-motor behavior in the plantar test; (3) effects of cross-fostering on nociception; and (4) analgesic effects of an acute injection of methamphetamine (1 mg/kg s.c.). Nociception was tested using the plantar test on postnatal days 85-90. Prenatal methamphetamine increased sensitivity to pain on forelimbs (p<0.0001) and hind limbs (p<0.05) in females only. Prenatal methamphetamine treated male rats fostered by adoptive injection stressed mothers had higher sensitivity to pain than prenatally injection stressed rats fostered by methamphetamine treated mothers (p<0.05). Acute methamphetamine induced analgesia faster in prenatally methamphetamine exposed rats than in controls. In all groups, analgesia increased in the cranio-caudal direction (p<0.0001). From our behavioral data it can be concluded that exposure to methamphetamine during the prenatal period completely dissociates the relationship between nociception and intensity of overall behavior observed in intact animals in adulthood. Thus, our results indicate that perinatal exposure to psychostimulants may have long-term impact on several functions related to dopaminergic system.

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“…60,68 FS and CS have been isolated from safflower seeds and possess antioxidant, anti-inflamatory activities, 59 anti-tumor, 65 anti-bacterial 66 and anti-stress potential and also involved in reducing depression and anxiety. 67 SER was administered to boost its levels in human brain in treating SER deficiency syndrome. 68 Some of the extensive uses of SER include treating patients suffering from the parkinson-like …”

Section: Health Benefits Of Serotoninmentioning

confidence: 99%

Phytoserotonin

Ramakrishna

Giridhar

Ravishankar

2011

Plant Signaling & Behavior

105

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Serotonin (5-hydroxytryptamine; SER) is one of the well-studied indoleamine neurotransmitter in vertebrates. Recently SER has also been reported in wide range of plant species. The precise function of SER at the physiological level, particularly growth regulation, flowering, xylem sap exudation, ion permeability and plant morphogenesis in plant system has not been clear. Though SER is found in different parts of plant species including leaves, stems, roots, fruits and seeds, the quantity of SER within plant tissues varies widely. SER has been recently shown as a plant hormone in view of its auxin-like activity. This brief review provide an overview of SER biosynthesis, localization, its role in plant morphogenesis and possible physiological functions in plants. This would certainly help to elucidate further the multiple roles of SER in plant morphogenesis. In the future it may form the basis for studies on involvement of SER in cellular signaling mechanisms in plants. Apart from these gaps in understanding the role of SER in ontogeny of plant physiology and ecological, adaptations have been emphasized. Thus, overall perspectives in this area of research and its possible implications have been presented.

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The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats

Cited by 15 publications

References 26 publications

Can Anxiety Tested in the Elevated Plus-maze Be Related to Nociception Sensitivity in Adult Male Rats?

Can Anxiety Tested in the Elevated Plus-maze Be Related to Nociception Sensitivity in Adult Male Rats?

Perinatal effect of methamphetamine on nociception in adult Wistar rats

Phytoserotonin

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