The selective inhibition by metopirone of 11β-hydroxylation in bovine adrenal perfusion of 17-hydroxyprogesterone (1)

Levy, Harold; Hwa, Chung; Carlo, James J.

doi:10.1016/0039-128x(65)90143-1

Steroids

1965

DOI: 10.1016/0039-128x(65)90143-1

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The selective inhibition by metopirone of 11β-hydroxylation in bovine adrenal perfusion of 17-hydroxyprogesterone (1)

Harold Levy

Chung Hwa

James J. Carlo

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Cited by 5 publications

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“…(Sweat and Bryson, 1965) and cholesterol side-chain cleavage (Bryson and Kaiser, 1965), but has little influence on 17 or 21 hydroxylation. Metyrapone behaves similarly to adrenochrome in being specific for 11/3 hydroxylation, and having little effect on either 17 or 21 hydroxylation (Levy et al, 1965). p-Mercuribenzoate is inhibitory to 11 and 21 hydroxylation, but less effective on 17 hydroxylation (Young et al, 1965).…”

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Adrenal gland steroid C-21 cytochrome P-450 reductase

Sweat¹,

Dutcher²,

Young³

et al. 1969

Biochemistry

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The adrenal gland mitochondrial cytochrome P-450 reductase system (adrenal flavoprotein and adrenodoxin) is shown in this investigation to enhance steroid 21 hydroxylation in carefully prepared microsomal suspensions and acetone powder extracts. Examination of the reductase components separately reveals that the enhancement can be accounted for on the basis of the flavoprotein moiety alone.This implicates flavoprotein as an electron carrier in steroid 21 hydroxylation. While it seems likely that the mitochondrial and microsomal flavoproteins are identical, there remains a possibility that different, yet compatible, species may exist for the two organelles. The current studies indicate that V^/teroid 11/3 hydroxylation was early shown to occur in adrenal gland cortex mitochondria (Sweat, 1951) and to require TPNH (Sweat and Lipscomb, 1955; Grant and Brownie, 1955) and molecular oxygen (Sweat et al., , 1956 Hayano et al., 1955a,b) as participants in the reaction. Shortly thereafter, 21 hydroxylation was shown to be associated with elements of the adrenal gland cortex endoplasmic reticulum (Plager and Samuels, 1954) and to also require TPNH (Ryan and Engel, 1956) and molecular oxygen (Cooper et al., 1963;Nakano et al., 1968). Both 11/3-and 21-hydroxylation reactions have been classified in the category of mixedfunction oxidases (Mason, 1957). While it has been suggested that steroid hydroxylations may occur as a generalized process, Mason (1957) has pointed out that nonspecific reactions characteristic of free radicals are not apparent in the steroid

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confidence: 99%

Adrenal gland steroid C-21 cytochrome P-450 reductase

Sweat¹,

Dutcher²,

Young³

et al. 1969

Biochemistry

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The inhibition by metopirone of 11β- and 19-hydroxylations of 11-deoxycortisol in bovine adrenal perfusion

1965

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The inhibition by metopirone of 11β- and 19-hydroxylations of androst-4-ene-3,17-dione in bovine adrenal perfusion (1)

1965

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The selective inhibition by metopirone of 11β-hydroxylation in bovine adrenal perfusion of 17-hydroxyprogesterone (1)

Cited by 5 publications

References 4 publications

Adrenal gland steroid C-21 cytochrome P-450 reductase

Adrenal gland steroid C-21 cytochrome P-450 reductase

The inhibition by metopirone of 11β- and 19-hydroxylations of 11-deoxycortisol in bovine adrenal perfusion

The inhibition by metopirone of 11β- and 19-hydroxylations of androst-4-ene-3,17-dione in bovine adrenal perfusion (1)

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