The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

“…Polyurethanes incorporated with YIGSR selectively promoted EC adhesion and proliferation while minimizing platelet adhesion [40,41]. Glass [42] and PEG hydrogels [43] modified with YIGSR also enhanced EC adhesion and migration.…”

Tissue Engineering for Tissue and Organ Regeneration

“…(Livant, 2000) Other peptides sequences such as laminin-derived YIGSR (tyrosine-isoleucine-glycine-serine-arginine), LRE (leucine-arginine-glutamic acid) or IKVAV (isoleucine-lysine-valine-alanine-valine) have potential application in nerve regeneration. (Fittkau, 2005;Pittier, 2005) YIGSR, unlike RGD and PHSRN, does not interact with the 67 kDa laminin binding protein. (Graf, 1987) In addition, YIGSR promotes the adhesion and spreading of many cell types including endothelial cells, fibroblasts, and smooth muscle cells.…”

Aspects of Urological Tissue Engineering

“…(Livant, 2000) Other peptides sequences such as laminin-derived YIGSR (tyrosine-isoleucine-glycine-serine-arginine), LRE (leucine-arginine-glutamic acid) or www.intechopen.com IKVAV (isoleucine-lysine-valine-alanine-valine) have potential application in nerve regeneration. (Fittkau, 2005;Pittier, 2005) YIGSR, unlike RGD and PHSRN, does not interact with the 67 kDa laminin binding protein. (Graf, 1987) In addition, YIGSR promotes the adhesion and spreading of many cell types including endothelial cells, fibroblasts, and smooth muscle cells.…”

“…(Massia, 2011) It was found that PEG surfaces functionalized with cell binding peptide RGD and YIGSR, significantly increased microvascular endothelial cell migration rates relative to RGD alone. (Fittkau, 2005) Another group demonstrated that degradation of endothelial ECMs with bacterial collagenase releases proangiogenic peptide fragments which can stimulate epithelial responses to injury and wound healing in vivo. (Demidova-Rice, 2011) It has been shown that sequences such as Col4-1, Col4-2, Fibr2, Fibr3, Ten1, Ten2, and Comb1 significantly increase the rate of sprout formation, which enhances cell-cell interactions and improves endothelial motility.…”