The self-assembly and aqueous solubilization of [60]fullerene with disaccharides

Bhoi, Vinod I.; Kumar, Sujit Baran; Murthy, C. N.

doi:10.1016/j.carres.2012.07.010

Cited by 24 publications

(20 citation statements)

References 41 publications

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“…The structures of these aggregates, including micelles, 1,2 vesicles, 3,4 bilayers, 5,6 bers 7,8 etc., can inuence the properties of surfactant solutions such as their solubilization ability for hydrophobic substances 9 or their viscous and viscoelastic properties, 10 and their performance in various applications. These self-assembled structures possess numerous applications in many elds, such as nanotechnology, 10,11 environment 12,13 and biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the self-assembled behaviors of C₁₈unsaturated fatty acids in arginine aqueous solution

et al. 2017

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In the field of drug delivery, there is growing concern over the self-assembly of fatty acids, since their structures and properties are similar to liposomes, which are characteristically nontoxic for humans, possess good biocompatibility and biodegradation, and are without immunogenicity. Changes in pH, temperature, concentration, molecular structure of the amphiphilic molecule, head group type and hydrocarbon chain length have significant effects on the self-assembled structures; however, the degree of unsaturation can also influence the self-assembled structures of fatty acids. The aggregation behaviors of the mixtures of arginine and three kinds of unsaturated fatty acids (UFAs, oleic acid, linoleic acid and linolenic acid) in aqueous solutions have been investigated. Phase transition from transparent micelles (L 1 phase) to birefringent bilayer structures (L a phase) occurred with increasing amounts of UFAs. However, the L a phase was different for macro and micro structures. Oleic acid with only one double bond was regarded as less flexible and curved, but with higher stacking, leading to a gradual phase transition process from the vesicle phase to the stacked lamellar phase in the L a phase region, which could be proved by cryogenic transmission electron microscopy (cryo-TEM) and polarizing microscopy observations combined with 2 H-nuclear magnetic resonance ( 2 H NMR) and rheological properties. The turbid vesicle phase with weak viscoelastic properties were only observed in linoleic acid and linolenic acid systems because UFAs with more than one double bond are easier to bend, indicating that highly curved vesicles are likely to form. Through the analysis of the proposed mechanism and FT-IR spectra, the synergistic effects of non-covalent interactions, including hydrogen bonding, electrostatic interaction, and hydrophobicity, were considered to be responsible for the aggregation behaviors. Finally, vesicles displayed their potential in encapsulating water-soluble model drugs such as calcein. The results show that drug-loaded vesicles could play a role in the potential applications in drug sustained delivery systems.

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Section: Introductionmentioning

confidence: 99%

Investigation on the self-assembled behaviors of C₁₈unsaturated fatty acids in arginine aqueous solution

et al. 2017

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“…The absorption intensity was enhanced as a function of time and completely reached steady state 1 h later (Figure b). Concurrently, the color of mixed solution transformed from violet to yellow, similar to the results reported by other water‐soluble fullerene systems,,, the results indicated that DPPH radical was almost entirely scavenged by the fullerene derivatives. But the absorption intensity of the characteristic peak of DPPH was not significantly decreased compared with the pure DPPH solution (Figure a).…”

Section: Resultsmentioning

confidence: 99%

“…The rate constants of HOPOs‐C 60 4a‐d and other fullerene derivatives are shown in Table . The kinetic behavior of HOPOs‐C 60 4a‐d all displayed a similar trend with higher k 1 than water‐soluble polyhydroxy fullerene grafting cellulose nanocrystals (CNC‐C 60 (OH) 30 ), lactose‐C 60 complex and fullerene polymer system (PDMA‐C 60 , PEO‐b‐PAA‐C 60 ) . The higher k 1 can be explained by the extent to which the fullerene molecule is shielded by the coil structure of the hydrophilic groups.…”

Section: Resultsmentioning

confidence: 99%

Chlorofullerene C₆₀Cl₆: A Precursor for Straightforward Preparation of Highly Water‐Soluble Poly‐hydroxypyridinone Fullerene Derivatives as Potential Radionuclide Chelators

et al. 2017

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Radionuclide internal contamination can induce chemical and radiological intoxication and produce harmful free radicals in vivo. Conventional studies on chelating agents have disregarded the damage of free radicals to the body. Therefore, novel poly‐hydroxypyridinone fullerene derivatives were designed and prepared by using chlorofullerene as precursor. The poor water solubility of fullerene was ameliorated by chemically modifying of hydrophilic hydroxypyridinone, and obtaining high Water‐soluble fullerene derivatives. The radical scavenging reaction kinetics of target products were studied. They all exhibited much higher rate constants than other fullerene polymer system. The CeIII ion was used as a simulated radionuclide for evaluating the binding ability of target products, and the values of conditional stability constants were about 5.15‐6.11. Thus, the bifunctional, Water‐soluble fullerene derivatives were successfully generated. The results provided basis for further study on the potential application of poly‐hydroxypyridinone fullerene derivatives as radionuclide chelators.

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“…The first step of the multiscale assembly of the whisker formation involves a molecular level polymer C 60 assembly driven by π-π stacking of the conjugated backbone of the polymer and the fullerene, resulting in the nanofibers. Murthy and coworkers 75 have recently demonstrated first example of solubilization of C 60 in water by complexation with disaccharides in mixed homogeneous solvent system. The complexation of hydrophobic water-insoluble C 60 dissolved in nonpolar solvent toluene and extremely water-soluble disaccharides dissolved in polar solvent DMSO resulted in a unique self-assembled highly crystalline water-soluble C 60 -disaccharide complex with average particle size ca.…”

Section: S E L F -A S S E M B Ly O F F U N C T I O N a L I Z E D Fullmentioning

confidence: 99%

Self-Assembled Fullerene Nanostructures

Shrestha¹,

Shrestha²,

Hill³

et al. 2013

J. Oleo Sci.

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The self-assembly and aqueous solubilization of [60]fullerene with disaccharides

Cited by 24 publications

References 41 publications

Investigation on the self-assembled behaviors of C₁₈unsaturated fatty acids in arginine aqueous solution

Investigation on the self-assembled behaviors of C₁₈unsaturated fatty acids in arginine aqueous solution

Chlorofullerene C₆₀Cl₆: A Precursor for Straightforward Preparation of Highly Water‐Soluble Poly‐hydroxypyridinone Fullerene Derivatives as Potential Radionuclide Chelators

Self-Assembled Fullerene Nanostructures

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The self-assembly and aqueous solubilization of [60]fullerene with disaccharides

Cited by 24 publications

References 41 publications

Investigation on the self-assembled behaviors of C18unsaturated fatty acids in arginine aqueous solution

Investigation on the self-assembled behaviors of C18unsaturated fatty acids in arginine aqueous solution

Chlorofullerene C60Cl6: A Precursor for Straightforward Preparation of Highly Water‐Soluble Poly‐hydroxypyridinone Fullerene Derivatives as Potential Radionuclide Chelators

Self-Assembled Fullerene Nanostructures

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Investigation on the self-assembled behaviors of C₁₈unsaturated fatty acids in arginine aqueous solution

Investigation on the self-assembled behaviors of C₁₈unsaturated fatty acids in arginine aqueous solution

Chlorofullerene C₆₀Cl₆: A Precursor for Straightforward Preparation of Highly Water‐Soluble Poly‐hydroxypyridinone Fullerene Derivatives as Potential Radionuclide Chelators