The self-assembly and dynamics of weakly multivalent, peptide-based, host-guest systems

Abstract

Chapter 2: Effects of variations in ligand density on cell signaling 2.1 Introduction 2.2 Surfaces with stochastic display of ligands 2.2.1 Ligand density variations in monolayers 2.2.2 Ligand density in bio-sensing 2.2.3 Activating the function of growth factor by spatially organizing binding ligands on SAMs 2.2.4 Ligand density variations in hydrogels 2.2.5 Ligand density variations on peptide amphiphiles 2.2.6 Ligand density variations in peptide nucleic acids 2.3 Surfaces with uniform arrangement of ligands 2.3.1 Ligand density variations on nanocorals 2.3.2 Spatial clustering of ligands 2.4 Conclusions and future perspectives 2.5 References Chapter 3: Employing the weakly binding aromatic amino acids for multivalent peptide complexation with β-CD printboards

Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter

“…Peptide-based multivalent interactions at interfaces of a biological system are of great importance. For example, the multivalency of carefully designed supramolecular peptide ligands was utilized in enhancing binding interaction with β-cyclodextrin (β-CD) to study host–guest relationships [ 7 ]. In another approach, multivalency was achieved using self-assembly of a coil/fiber-forming peptide to study the binding interaction with antibody and carbohydrate-binding motifs [ 8 ].…”