The semaphorins and their receptors as modulators of tumor progression

Neufeld, Gera; Mumblat, Yelena; Smolkin, Tanya; Toledano, Shira; Nir-Zvi, Inbal; Ziv, Keren; Kessler, Ofra

doi:10.1016/j.drup.2016.08.001

Cited by 65 publications

(52 citation statements)

References 197 publications

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“…Answering the above questions will help us design effective strategies to accurately and specifically modulate semaphorin signaling for therapeutic purposes. Recent studies have shown that tumor angiogenesis can be regulated by different semaphorins . A better understanding of the molecular mechanism by which semaphorins regulate blood vessel formation may lead to identification of novel intervention targets for cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that tumor angiogenesis can be regulated by different semaphorins. 4,82 A better understanding of the molecular mechanism by which semaphorins regulate blood vessel formation may lead to identification of novel intervention targets for cancer treatment. Another potential area for translational research of semaphorin signaling is regenerative medicine.…”

Section: Discussionmentioning

confidence: 99%

“…To date, more than 20 semaphorin members have been discovered in viruses, invertebrates, and vertebrates . In addition to acting as guidance cues for axon growth in the nervous system, semaphorins have been implicated in many other systems, such as immune responses, tumor angiogenesis, bone development and homeostasis, and cardiovascular development …”

Section: Semaphorins and Their Corresponding Plexin Receptorsmentioning

confidence: 99%

“…S emaphorins are a family of secreted and membranebound molecules that play critical functions in diverse biological processes. [1][2][3][4][5][6][7][8][9] SEMA1A/Fasciclin IV is the founding member of the semaphorin family and was first reported in 1992 as a regulator of axon branching in the growth cone of grasshopper embryos. 10 To date, more than 20 semaphorin members have been discovered in viruses, invertebrates, and vertebrates.…”

mentioning

confidence: 99%

“…3,5,11 In addition to acting as guidance cues for axon growth in the nervous system, semaphorins have been implicated in many other systems, such as immune responses, tumor angiogenesis, bone development and homeostasis, and cardiovascular development. [1][2][3][4][5][6][7][8][9] Semaphorins are categorized into 8 classes. Classes 1 and 2 are found in invertebrates, classes 3 to 7 are present in vertebrates, and class V semaphorins are found only in viruses.…”

mentioning

confidence: 99%

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Role of Semaphorin Signaling During Cardiovascular Development

Sun

Liu

et al. 2018

JAHA

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Semaphorins and Their Corresponding Plexin Receptorsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Role of Semaphorin Signaling During Cardiovascular Development

Sun

Liu

et al. 2018

JAHA

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Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy

Liang

Zhang

et al. 2022

Advanced Science

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Diabetic retinopathy (DR) is the leading cause of vision loss in working age population. Intravitreal injection of anti‐VEGF antibody is widely used in clinical practice. However, about 27% of patients show poor response to anti‐VEGF therapy and about 50% of these patients continue to have macular thickening. Frequent intravitreal injections of antibody may increase the chance of endophthalmitis and cause visual loss or even blindness once happened. Therefore, there is a greatly urgent need for novel noninvasive target to treat DR clinically. Here, the formulation of a smart supramolecular peptide (SSP) eye drop for DR treatment that is effective via specifically identifying and capturing soluble semaphorin 4D (sSema4D), a strongly pro‐angiogenesis and exudates factor, is reported. The SSP nanostructures encapsulate sSema4D so that all biological effects mediated by three receptors of sSema4D are inhibited, thereby significantly alleviating pathological retinal angiogenesis and exudates in DR. Moreover, it is found that combination of SSPs eye drop and anti‐VEGF injection shows better therapeutic effect over anti‐VEGF treatment alone. Overall, SSP eye drop provide an alternative and effective method for noninvasive treatment for DR.

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SEMA3B‐AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B‐dependent VEGF signaling pathway activation

Wang,

Chen,

et al. 2023

MedComm

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Mounting evidence has demonstrated the considerable regulatory effects of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of various carcinomas. LncRNA Semaphorin 3B (SEMA3B) antisense RNA 1 (SEMA3B‐AS1) has been found to be dysregulated in a few carcinomas recently. However, its potential function and mechanism in colorectal carcinoma (CRC) have not yet been examined. Here we show that SEMA3B‐AS1 acts as a crucial regulator of CRC progression. We found that SEMA3B‐AS1 expression was downregulated in CRC cell lines and tissues. Downregulation of SEMA3B‐AS1 was significantly associated with poor survival in CRC patients. Overexpression of SEMA3B‐AS1 reduced the cell growth and metastasis of CRC in vivo and in vitro. In addition, SEMA3B‐AS1 promoted the expression of its sense‐cognate gene SEMA3B, a member of the Semaphorin family (SEMAs), by recruiting EP300 to induce H3K9 acetylation at the SEMA3B promoter. Furthermore, we proved that SEMA3B‐AS1 suppressed CRC angiogenesis by affecting the vascular endothelial growth factor signaling pathway activation which was regulated by the SEMA3B‐NRP1 axis. Our work unravels a novel mechanism of SEMA3B‐AS1 in the inhibition of CRC malignant progression and highlights its probability as a new promising diagnostic marker and therapeutic target for CRC interventions.

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The semaphorins and their receptors as modulators of tumor progression

Cited by 65 publications

References 197 publications

Role of Semaphorin Signaling During Cardiovascular Development

Role of Semaphorin Signaling During Cardiovascular Development

Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy

SEMA3B‐AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B‐dependent VEGF signaling pathway activation

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