The semi-synthetic molecule [4″,5″] dihydro-obovatin isolated from Tephrosia Toxicaria pers reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats

Biological and Molecular Docking Evaluation of a Benzylisothiocyanate Semisynthetic Derivative From Moringa oleifera in a Pre-clinical Study of Temporomandibular Joint Pain

“…MC-H is a promising molecule showing high antinociceptive effects even at low concentrations, showing the same effect of indomethacin and morphine in a 5,000 times lower dose ( dos Santos et al, 2018 ). This occurs possibly due to the triple acetylation at the carbons (2′, 3′, and 4′) of the rhamnose sugar provides more stability and renders the molecule more lipophilic, enabling a greater ability to cross organic barriers such as the blood-brain barrier ( Dvorak, 2010 ; do Val et al, 2018 ). Tests performed with seven semi-synthetic compounds produced from MC-1 isolated from M. oleifera and structurally similar to MC-H (presence of benzene ring and sugar rhamnose) showed that the anti-inflammatory activity of these compounds is reduced by up to 8 times in un-acetylated derivatives ( dos Santos et al, 2018 ).…”