The Sensitivity and Specificity of Nerve Fiber Layer Measurements in Glaucoma as Determined With Scanning Laser Polarimetry

Tjon-Fo-Sang, Martha J.; Lemij, Hans G

doi:10.1016/s0002-9394(14)70993-6

Cited by 176 publications

(115 citation statements)

References 24 publications

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“…This technology has been shown to provide reproducible RNFL measurements and to differentiate glaucoma patients from normal subjects with sensitivities and specificities between 72 and 78%, and 56 and 92%, respectively. [47][48][49][50][51][52] Imaging artifacts such as a poorly compensated corneal birefringence can hamper the accuracy of the device in clinical practice. 53 The introduction of a variable corneal polarization compensator (GDxVCC) attempted to alleviate this problem and resulted in improved diagnostic accuracy.…”

Section: Cslomentioning

confidence: 99%

Assessment of rates of structural change in glaucoma using imaging technologies

Mansouri

Leite

Medeiros

et al. 2011

Eye

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Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methods Review of literature. Results Imaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLP), and optical coherence tomography (OCT), provide quantifiable and reproducible measurements of the optic disc and parapapillary retinal nerve fibre layer (RNFL). Rates of change as quantified by the rim area (RA) (for CSLO) and RNFL thickness (for SLP and OCT) are related to glaucoma progression as detected by conventional methods (eg, visual fields and optic disc photography). Evidence shows that rates of RNFL and RA loss are significantly faster in progressing compared with nonprogressing glaucoma patients. Conclusion Measurements of rates of optic disc and RNFL change are becoming increasingly precise and individualized. Currently available imaging technologies have the ability to detect and quantify progression in glaucoma, and their measurements may be suitable end points in glaucoma clinical trials.

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Section: Cslomentioning

confidence: 99%

Assessment of rates of structural change in glaucoma using imaging technologies

Mansouri

Leite

Medeiros

et al. 2011

Eye

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“…[9][10][11][12] Most of these studies explored the standard parameters provided by the GDx (described elsewhere 13 ) or combinations of these (some including the built-in classifier named The Number). Despite their fair to excellent performance, these parameters may be quite insensitive to wedge defects, especially narrow ones, since they are based either on general statistics of measurements along an ellipse around the optic disc or on measurements in a fairly large area, such as an image quadrant.…”

Section: Introductionmentioning

confidence: 99%

Automated detection of wedge-shaped defects in polarimetric images of the retinal nerve fibre layer

Vermeer

Reus

Vos

et al. 2005

Eye

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Purpose Automated glaucoma detection in images obtained by scanning laser polarimetry is currently insensitive to local abnormalities, impairing its performance. The purpose of this investigation was to test and validate a recently proposed algorithm for detecting wedge-shaped defects. Methods In all, 31 eyes of healthy subjects and 37 eyes of glaucoma patients were imaged with a GDx. Each image was classified by two experts in one of four classes, depending on how clear any wedge could be identified. The detection algorithm itself aimed at detecting and combining the edges of the wedge. The performance of both the experts and the algorithm were evaluated. Results The interobserver correlation, expressed as ICC(3,1), was 0.77. For the clearest cases, the algorithm yielded a sensitivity of 80% at a specificity of 93%, with an area under the ROC of 0.95. Including less obvious cases by the experts resulted in a sensitivity of 55% at a specificity of 95%, with an area under the ROC of 0.89. Conclusions It is possible to automatically detect many wedge-shaped defects at a fairly low rate of false-positives. Any detected wedge defect is presented in a user-friendly way, which may assist the clinician in making a diagnosis.

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“…A polarimetria de varredura a laser (PVL) é uma nova técnica para uma análise quantitativa da espessura da camada de fibras nervosas da retina 6,7 . Apresenta uma boa sensibilidade (96%) podendo ser o primeiro teste para rastreamento do glaucoma 8 . Entretanto, outros autores encontraram uma menor sensibilidade (87,3%) e recomendam a associação com os dados clínicos e semioló-gicos do paciente 9 .…”

Section: Introductionunclassified

Reprodutibilidade do exame de medida da camada de fibras nervosas da retina por meio da polarimetria de varredura a laser

Duarte

Paranhos

Galhardo

et al. 1999

Arq. Bras. Oftalmol.

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Reprodutibilidade do exame de medida da camada de fibras nervosas da retina por meio da polarimetria de varredura a laser Objetivo: Analisar a reprodutibilidade das medidas da espessura da camada de fibras nervosas da retina intra e inter-observador.Material e Métodos: As medidas da camada de fibras nervosas foram realizadas em 26 olhos normais por três examinadores diferentes, os quais tomaram três imagens de cada olho. Com base nestas imagens foi executada a média das imagens pelo programa do aparelho. A cada examinador foi solicitado que escolhesse a melhor imagem para cada exame. Foram analisados os resultados obtidos com a melhor imagem, bem como os da média das imagens. Foi calculada a média da espessura da camada de fibras nervosas nas regiões superior, nasal, temporal e inferior e suas relações. Determinou-se a reprodutibilidade nestas circunstâncias tanto inter como intra-observador por meio de teste de análise de variância por postos de Friedman.Resultados Conclusões: A análise dos dados indica ótima reprodutibilidade do exame intra-observador, e na avaliação inter-observador os melhores resultados de reprodutibilidade são obtidos quando a média das imagens fornecida pelo programa do equipamento é empregada. Reproducibility of retinal nerve fiber layer measurement by scanning laser polarimetryTrabalho realizado no Setor de Glaucoma do Departamento de Oftalmologia da Universidade Federal de São Paulo -Escola Paulista de Medicina -Rua Botucatu, 820. Vila Clementino.

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The Sensitivity and Specificity of Nerve Fiber Layer Measurements in Glaucoma as Determined With Scanning Laser Polarimetry

Cited by 176 publications

References 24 publications

Assessment of rates of structural change in glaucoma using imaging technologies

Assessment of rates of structural change in glaucoma using imaging technologies

Automated detection of wedge-shaped defects in polarimetric images of the retinal nerve fibre layer

Reprodutibilidade do exame de medida da camada de fibras nervosas da retina por meio da polarimetria de varredura a laser

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