The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States.

Schlauder, George G.; Dawson, George J.; Erker, James C.; Kwo, Paul Y.; Knigge, Mark F.; Smalley, David L.; Rosenblatt, Jon E.; Desai, Suresh M.; Mushahwar, Isa K.

doi:10.1099/0022-1317-79-3-447

Cited by 307 publications

(255 citation statements)

References 26 publications

Supporting

Mentioning

242

Contrasting

Unclassified

Order By: Relevance

“…[9][10][11] Around the same time, HEV-like genomic sequences were identified in specimens from animals, in particular pigs. 12 Further work prompted by these observations has led to a major change in our understanding about HEV and its epidemiology, including the routes of transmission and clinical outcomes.…”

mentioning

confidence: 98%

Hepatitis E: Epidemiology and Natural History

Aggarwal

2013

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

mentioning

confidence: 98%

Hepatitis E: Epidemiology and Natural History

Aggarwal

2013

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

“…Genotype 2 contains a sequence of an isolate from an outbreak in Mexico (16). Genotype 3 groups sequences of isolates found in the Unites States, European countries, Japan and Argentina (10,30,(32)(33)(34)37). Genotype 4 contains sequences of isolates found in China, Taiwan and Japan (15,39,47,48).…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of swine hepatitis E virus from Southeastern Brazil

Paiva

Tzaneva

Haddad

et al. 2007

Braz. J. Microbiol.

View full text Add to dashboard Cite

Despite serological evidences of presence of hepatitis E virus (HEV) in humans or other animals, until this study the virus had not been detected and molecular characterization of the isolate that circulates in Brazil had not been described. Thus, we collected stool samples of young pigs and tested for presence of HEV RNA by RT-PCR, using primers for partial amplification of ORF2 sequence. Phylogenetic analysis with sequence obtained from the amplified products revealed that the HEV isolate identified here was most closely related to HEV isolates of genotype 3, which is commonly detected in HEV infected pigs. Nucleotide sequence analyses carried out with the entire amplified fragment, ORF2/ORF3 overlapping and ORF2 non-overlapping sequences showed highest identities with the US isolate of genotype 3. Similarly, amino acid sequence analyses done with the entire amplified fragment, ORF2 non-overlapping, ORF2 and ORF3 overlapping sequences also showed highest identities with the genotype 3 isolate. Presence, in Brazil, of HEV of genotype 4, which also infects pigs, as well as HEV strains that infect humans still remain to be detected and characterized.

show abstract

“…HEVs can be classified into 4 genotypes based on the phylogenetic analysis of the viral genomes. The Burmese, Mexican, American, and Chinese HEV strains are the prototype of genotypes 1, 2, 3, and 4, respectively [6,18,19,23]. Genotype 1 HEV was isolated from several countries in Asia and Africa, genotype 2 was from Mexico, Nigeria, and Chad, genotype 3 was from a lot of countries in America, Asia, Europe, and Oceania, and genotype 4 was exclusively from Asian countries [10].…”

mentioning

confidence: 99%

“…However, sporadic hepatitis cases caused by HEV infections have been reported recently in industrialized countries [5,15,19]. HEV belongs to the genus Hepevirus in the family Hepeviridae and has a 7.2-kb positive-sense single-stranded RNA genome [17].…”

mentioning

confidence: 99%

Determination of Fecal Shedding Rates and Genotypes of Swine Hepatitis E Virus (HEV) in Korea

Kim

et al. 2008

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Hepatitis E virus (HEV) infection induces an acute hepatitis or a subclinical disease in humans. It is known that HEV is a zoonotic agent and pigs are major reservoirs of HEV. This study was conducted to determine the fecal shedding rates of HEV in various age groups of pigs and identify the genotypes of swine HEV prevailing in Korea. A total of 565 fecal samples were collected from suckling piglets, post-weaning pigs, growing pigs, and sows at 12 swine farms. RT-PCR was used to detect the presence of swine HEV in the feces. Every swine farm examined in this study had HEV-infected pigs. The fecal shedding rates of the swine HEV at individual farms were in the range of 2.1-35.4%. The overall fecal shedding rate of HEV in individual pigs was 17.5%. The HEV shedding rates of suckling piglets, post-weaning pigs, growing pigs and sows in their feces were 6.3, 16.3, 38.0 and 9.3%, respectively. When the genotypes of swine HEVs identified in this study were determined, they were all grouped into genotype 3. They were further subdivided into subtype 3a together with human and swine HEVs isolated in the U.S.A.

show abstract

The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States.

Abstract: A variant of hepatitis E virus (HEV),

Cited by 307 publications

References 26 publications

Hepatitis E: Epidemiology and Natural History

Hepatitis E: Epidemiology and Natural History

Molecular characterization of swine hepatitis E virus from Southeastern Brazil

Determination of Fecal Shedding Rates and Genotypes of Swine Hepatitis E Virus (HEV) in Korea

Contact Info

Product

Resources

About