The Sequence of Mouse Dihydropteridine Reductase cDNA, and Comparison with Human and Rat Sequences

Transient Activation of Dihydropteridine Reductase by Ca2+-activated Proteolysis

“…3a). These sequences correspond to the N-terminal regions around about 30 -60th of DHPR subunits of rat (Shahbaz et al, 1987), mouse (Yang et al, 1996), and human (Dahl et al, 1987) enzymes, as shown in Fig. 3a.…”

Transient Activation of Dihydropteridine Reductase by Ca2+-activated Proteolysis.

“…Proteins on the gel were stained with Coomassie brilliant blue G-250. (Edman and Begg, 1967) as described in the text with reference to the sequences of DHPR from various origins (Dahl et al, 1987;Yang et al, 1996;Shahbaz et al, 1987). Asterisks indicate N-terminal sites of fragment A (*) and fragment B (**), respectively.…”

“…DHPR has been purified to homogeneity from many sources (Craine et al, 1972;Hasegawa, 1977;Korri et al, 1977;Webber et al, 1978;Firgaira et al, 1981). The cDNAs of human (Dahl et al, 1987), mouse (Yang et al, 1996), and rat (Shahbaz et al, 1987) DHPR have been cloned, and their deduced amino acid sequences are almost identical.…”