The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5α
Abstract:1Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and 2 tumor growth. We used our high-content screening assay to identify kinases impacting 3 invadopodia formation. Among the top hits we selected TAO3, a STE20-like kinase of the GCK 4 subfamily, for further analysis. TAO3 was over-expressed in many human cancers, and regulated 5 invadopodia formation in melanoma, breast and bladder cancers. Furthermore, TAO3 catalytic 6 activity facilitated melanoma growth in 3-dimen… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.