The serological and genetic basis of the <i>cis</i>‐AB blood group in Korea

Cho, D.; Kim, S.-H.; Jeon, Mee Jeong; Choi, Kai-Luk; Kee, Seung‐Jung; Shin, Myung Geun; Shin, Jong Hee; Suh, Soon Pal; Yazer, Mark H.; Ryang, Dong‐Wook

doi:10.1111/j.1423-0410.2004.00528.x

Cited by 42 publications

(53 citation statements)

References 7 publications

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“…The allele frequencies of O, A, and B were 50.1, 29.5, and 20.4 %, respectively, in controls and 49.4, 32.0, and 18.5 %, respectively, in GC patients. These results were consistent with previous studies [19]. As compared with blood group O, blood group A, but not groups AB or B, was associated with a significantly increased risk of GC overall (adjusted OR 1.28 and 95 % CI 1.09-1.50).…”

Section: General Characteristics Of Subjectssupporting

confidence: 92%

“…Thus, there is the possibility of a discrepancy between serological phenotypes and those predicted from genotypes. However, the error rate is considered to be negligible because the ABO subgroup frequency in the general population of southwestern Korea included in this study, (Yeonggwang and Muan counties and Namwon city) was only 0.114 % [19]. It was also reported that the discordance rates between genotypes and phenotypes defined as groups A, B, AB, and O were 0.18 % (2/1134 samples) in a Japanese population and 0.12 % (2/ 1700) in our previous study [17,20].…”

Section: Discussionmentioning

confidence: 86%

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Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population

et al. 2012

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Background Although previous studies have demonstrated an association between ABO blood group and the risk of gastric cancer (GC), only one study has identified these associations using the ABO genotype; however, that study did not evaluate sex differences in this association. The aim of the present study was to investigate whether there are sex-specific differences in the ABO genotypeassociated risk of GC. In addition, we explored the association of the ABO genotype and the clinicopathologic characteristics of GC in a Korean population.Methods We conducted a large-scale case-control study of 3245 GC patients (2204 males, 1041 females) and 1700 controls (821 males, 879 females). The ABO genotype was determined by multicolor real-time polymerase chain reaction (PCR) using displacing probes. Results As compared with genotype OO, genotypes AA and AO in females, but not in males, were associated with a significantly increased risk of GC (odds ratio [OR] 1.56 and 95 % confidence interval [CI] 1.08-2.26 for AA; OR 1.57 and 95 % CI 1.21-2.03 for AO). In a subgroup analysis, blood group A had a significantly increased risk of diffuse-type GC (OR 2.00, 95 % CI 1.43-2.78), but not of intestinal-type (OR 1.31, 95 % CI 0.96-1.79) or mixedtype GC (OR 1.43, 95 % CI 0.92-2.24). Conclusion The ABO genotypes AA and AO were significantly associated with GC only in females and only for diffuse-type GC. These data suggest that the association between ABO blood group and GC risk may differ according to sex and histological type.

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Section: General Characteristics Of Subjectssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 86%

Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population

et al. 2012

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“…Song et al genotyped 222 samples and reported the ABO genotype frequencies of A101/A101, A101/O02, and A101/ B101 to be 0.00%, 1.35%, and 0.45%, respectively [15]. Also, the cis-AB blood group is rare and the overall frequency of this blood group was determined to be 0.0354% among southwestern Korean blood donors [16].…”

Section: Discussionmentioning

confidence: 99%

Rapid ABO Genotyping Using Whole Blood without DNA Purification

Lee¹,

Park

Yang

et al. 2009

Ann Lab Med

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“…Cases of interest were tested by both automated devices. In cases of the AB blood type, forward typing with anti-A1 (anti-A1 lectin, Ortho Clinical Diagnostics) was additionally performed to confirm A 2 B or A 2 B 3 phenotypes, which are typical cis-AB blood phenotypes in Korea [8][9][10]. Reagents used in serologic tests were as follows: forward typing was performed using Anti-A, Anti-B, and Anti-D BioClone reagent (Ortho Clinical Diagnostics) by both tile and tube method.…”

Section: Evaluation Of Suspected Cis-ab Casesmentioning

confidence: 99%

ABO Mistyping of cis-AB Blood Group by the Automated Microplate Technique

Chun

Ryu

Cha

et al. 2018

Transfus Med Hemother

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Background: The cis-AB phenotype, although rare, is the relatively most frequent of ABO subgroups in Koreans. To prevent ABO mistyping of cis-AB samples, our hospital has applied a combination of the manual tile method with automated devices. Herein, we report cases of ABO mistyping detected by the combination testing system. Methods: Cases that showed discrepant results by automated devices and the manual tile method were evaluated. These samples were also tested by the standard tube method. The automated devices used in this study were a QWALYS-3 and Galileo NEO. Exons 6 and 7 of the ABO gene were sequenced. Results: 13 cases that had the cis-AB allele showed results suggestive of the cis-AB subgroup by manual methods, but were interpreted as AB by either automated device. This happened in 87.5% of these cases by QWALYS-3 and 70.0% by Galileo NEO. Genotyping results showed that 12 cases were ABO*cis-AB01/ABO*O01 or ABO*cis-AB01/ABO*O02, and one case was ABO*cis-AB01/ ABO*A102. Conclusion: Cis-AB samples were mistyped as AB by the automated microplate technique in some cases. We suggest that the manual tile method can be a simple supplemental test for the detection of the cis-AB phenotype, especially in countries with relatively high cis-AB prevalence.

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The serological and genetic basis of the cis‐AB blood group in Korea

Cited by 42 publications

References 7 publications

Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population

Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population

Rapid ABO Genotyping Using Whole Blood without DNA Purification

ABO Mistyping of cis-AB Blood Group by the Automated Microplate Technique

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