The Serological Diagnosis of Influenza in Infancy

Nr, Grist

doi:10.1177/003693305700200603

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Under 6 months of age isolation of B. pertussis was much conmnoner than positive serological findings; over 1 year of age serological tests were more often positive than were cultures. Our study suggests that two agerelated factors were involved in this difference-namely, a poor or delayed antibody response by the young infant as has been previously reported in other respiratory infections (Grist, 1957;Chanock et al, 1961;Ross et al, 1964) and the low proportion of children under 6 months of age who had been fully immunized against B. pertussis. In some children previous immunization appeared to have suppressed growth of B. pertussis in the nasopharynx but not the serological response.…”

Section: Discussionsupporting

confidence: 77%

Diagnosis of Whooping Cough: Comparison of Serological Tests with Isolation of Bordetella Pertussis

1970

BMJ

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Section: Discussionsupporting

confidence: 77%

Diagnosis of Whooping Cough: Comparison of Serological Tests with Isolation of Bordetella Pertussis

1970

BMJ

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“…Whatever the final explanation may prove to be, the demonstration that differences can be measured serologically in the nucleoproteins isolated from several strains of type A influenza virus is believed to be a unique and important finding. Grist's observation (30) that an element of strain specificity is demonstrable when soluble antigens prepared from infected egg membranes are used to test the acute and convalescent sera of infants, support the interpretation offered. Asian AA/~ vaccination against influenza, and because Schiifer (17) has shown that the hemagglutinin isolated from KP virus induced immunity when used as a vaccine, it was of special interest to test the capacity of these viruses and their corresponding hemagglutinins to induce antibody by vaccination.…”

Section: Other Biologic Activities Of Preparations Of Influenza Subunmentioning

confidence: 79%

Physical and Biological Properties of Influenza Virus Components Obtained After Ether Treatment

Davenport

Rott

Schäfer

1960

The Journal of Experimental Medicine

117

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The Rostock strain of fowl plague, the swine, A, A', and Asian strains of influenza A as well as their hemagglutinin and internal s antigen subunits obtained after ether splitting, were found to be morphologically indistinguishable when examined simultaneously. Hemagglutinin fractions reacted in a highly strain specific manner when tested by hemagglutination inhibition or by complement fixation using sera obtained after infection. With the same sera internal s antigen fractions were shown to be serologically distinguishable by complement fixation. This observation may stimulate interest in the feasibility of employing immunologic techniques for the study of nucleoproteins. The significance of the findings reported is discussed.

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“…However, if the child's clinical illness is prolonged and no routine positive virological findings have been found, the meningococcal CF test is worth consideration. It would seem that even in infants the CF antibody response to meningococcal infection is good; this contrasts with the absence or slow development in young children of CF antibodies in response to many viral infections (Anderson, Donnelly, French, Kalra & White, 1953;Grist, 1957).…”

Section: Group 1: Proven Meningococcalmentioning

confidence: 95%

Meningococcal ‘aseptic’ meningitis

Ross

Stevenson

1962

Epidemiol. Infect.

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The usefulness of the meningococcal CF test was assessed by investigating sera from (a) patients with meningococcal meningitis from whom meningococci had been isolated, and (b) patients with aseptic meningitis in whom no virus aetiology had been demonstrated and from whose C.S.F. no bacteria had been isolated.Meningococcal CF antibodies were relatively strain-specific; cross-reacting anti-bodies to heterologous strains were irregular both qualitatively and quantitatively.Positive meningococcal CF tests were obtained in 8 cases of aseptic meningitis, 3 showing a predominance of lymphocytes and 5 a predominance of polymorpho-nuclears in C.S.F. As a result of these positive tests, the cases of lymphocytic aseptic meningitis were given energetic antibiotic therapy to avoid the possibility of more chronic infection.We wish to thank many clinical and bacteriological colleagues for their co-operation, and Prof. S. Graham for details of one case. We are grateful to Dr Patricia Bradstreet, Standards Laboratory for Serological Reagents, London, N.W. 9, for meningococcal agglutination results, and to Miss C. Gourlay for valuable technical assistance.

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The Serological Diagnosis of Influenza in Infancy

Cited by 5 publications

References 12 publications

Diagnosis of Whooping Cough: Comparison of Serological Tests with Isolation of Bordetella Pertussis

Diagnosis of Whooping Cough: Comparison of Serological Tests with Isolation of Bordetella Pertussis

Physical and Biological Properties of Influenza Virus Components Obtained After Ether Treatment

Meningococcal ‘aseptic’ meningitis

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