The Serology of Febrile Transfusion Reactions

Rie, M.A. de; Dalen, C.M. van der Plas-van; Engelfriet, C.P.; Borne, A. E. G. K. Von Dem

doi:10.1159/000466359

Cited by 25 publications

(21 citation statements)

References 7 publications

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“…They can be defined as rise of body temperature by 1 °C or more within the first 4 h of transfusion and normalization of the temperature within 48 h, if transfusion of a bacterially contaminated blood product can be excluded and if no signs of hemolysis are found [1,2]. Patients with isolated febrile reactions may otherwise be asymptomatic or may experience rigor and chills.…”

Section: Febrile Non-hemolytic Transfusion Reactionsmentioning

confidence: 99%

“…In the patients studied by Decary et al [3], 64% of patients with nonhemolytic transfusion reactions had leukocyte antibodies as compared to 30% of control patients. De Rie et al [1] further characterized antibodies as human leukocyte antigen (HLA-), platelet-and granulocyte antibodies in patients with febrile reactions. HLA antibodies were the most common, followed by platelet antibodies and the least common granulocyte antibodies.…”

Section: Febrile Non-hemolytic Transfusion Reactionsmentioning

confidence: 99%

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Reactions Induced by Platelet Transfusions

Kiefel¹

2008

Transfus Med Hemother

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Platelet transfusions play a central role in therapeutic regimens for patients with hematologic/oncologic diseases who develop severe thrombocytopenia either in the course of their disease or following cytostatic therapy. Like other blood components, platelet transfusions have achieved a high degree of safety as far as transmission of viral diseases is concerned. However, transfusion of platelet concentrates is accompanied by a high frequency of febrile and anaphylactoid reactions. In rare cases, recipients of platelet concentrates are threatened by severe reactions as septic complications due to bacterial contamination of platelet concentrates, transfusionrelated acute lung injury and severe anaphylactic episodes.

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Section: Febrile Non-hemolytic Transfusion Reactionsmentioning

confidence: 99%

Section: Febrile Non-hemolytic Transfusion Reactionsmentioning

confidence: 99%

Reactions Induced by Platelet Transfusions

Kiefel¹

2008

Transfus Med Hemother

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“…Another concern raised in reports of HLA antibodies causing reactions is that the presence of the HLA antibody may have obscured the simultaneous presence of another cell-specific antibody. This has been shown by de Rie et al [9] who demonstrated the presence of platelet-specific antibody in 12 of 40 sera containing HLA antibody by studying reaction patterns and performing absorption and elution studies. This pres ent report ruled out the presence of underlying neutrophil or platelet-specific antibody after removing lymphocyto toxic antibody by lymphocyte absorption and testing the absorbed sera against a panel of cells including those from the implicated donors.…”

Section: Discussionmentioning

confidence: 78%

“…Severe febrile and pulmonary reactions, sometimes fatal, have occurred with transfusions to patients with antibodies to antigenic determinants on red cells [1] and leukocytes [2][3][4][5][6][7][8][9]. Non hemolytic transfusion reactions have also occurred in the absence of detectable recipient antibody due to the pas sive transfusion of donor antibody reacting with the recipient's red cell [10,11], platelet [12,13], granulocyte [14,15] or HLA [16][17][18] antigens.…”

Section: Introductionmentioning

confidence: 99%

Platelet Transfusion Reaction Associated with Interdonor HLA Incompatibility

Eastlund¹,

McGrath²,

Burkart³

1988

Vox Sanguinis

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An HLA-compatible platelet transfusion was followed by chills, fever, and severe respiratory distress in a multitransfused patient with chronic lymphocytic leukemia. During the previous 7 days the patient had received blood products without incident, including 8 units of red blood cells (RBC), 24 units of pooled random donor platelet concentrates, and five HLA-compatible platelet pheresis products. The patient had no demonstrable RBC, HLA lymphocytotoxic, platelet or granulocyte antibodies. The platelet donor, a multiparous female, had no granulocyte or RBC antibodies but had lymphocytotoxic antibodies against HLA-A2 CREG (cross-reacting group A2, A28, A23, A24) which reacted not with lymphocytes of the patient but with lymphocytes of the donor whose RBC were transfused 24 h prior to the platelet transfusion reaction and whose HLA type is A23, A24; B44, B57. No RBC donors had HLA lymphocytotoxic, granulocyte, or platelet antibodies against the platelet donor. The patient received three subsequent platelet transfusions from the same donor after removal of the antibody-laden plasma with no adverse reaction. These data suggest an interdonor reaction caused by the presence of cells from the RBC donor received by the patient 24 h prior to the transfusion of donor lymphocytotoxic antibody to HLA-A2 CREG antigens.

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“…Febrile nonhemolytic transfusion reactions may be caused by granulocyte-specific alloantibodies [27]. The relative importance of granulocyte, HLA class I and platelet antibodies is not quite as clear although HLA-specific antibodies were most often found associated with this kind of transfusion reaction [28]. Recent data suggest that many cases of febrile transfusion reaction to platelet concentrates may not be immunemediated but caused by cytokines produced by contaminating leukocytes during storage [29].…”

Section: Clinical Conditionsmentioning

confidence: 99%

Granulocyte Antibody-Mediated Neutropenias and Transfusion Reactions

Bux¹

1999

Transfus Med Hemother

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Objective: This review summarizes the neutropenias and transfusion reactions which are caused by granulocyte antibodies. The granulocyte antigens involved are described, and methods for the detection of granulocyte antibodies and antigens are discussed. Data Source: Review of the literature and results of studies performed at the Institut für Klinische Immunologie und Transfusionsmedizin. Selection Criteria: Peer-reviewed journals and papers relevant to the topic. Results: Granulocyte antibodies cause a variety of diseases, including alloimmune neonatal neutropenia, transfusion-related acute lung injury, refractoriness to granulocyte transfusions, febrile transfusion reactions, immune neutropenia after bone marrow transplantation, autoimmune neutropenia, and drug-induced immune neutropenia. A number of antigens has been described of which the NA1, NA2, NB1, SH, and the 5b antigens proved to be the most important ones. A combination of granulocyte agglutination and immunofluorescence tests together with a panel of typed cells represents currently the best means of detection. Conclusions: The detection and determination of granulocyte antibodies and antigens are essential for the diagnosis of immune neutropenias and of granulocyte antibody-induced transfusion reactions. Granulocyte cross-matching will improve the effects of granulocyte concentrates and avoid possible severe side effects.

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The Serology of Febrile Transfusion Reactions

Cited by 25 publications

References 7 publications

Reactions Induced by Platelet Transfusions

Reactions Induced by Platelet Transfusions

Platelet Transfusion Reaction Associated with Interdonor HLA Incompatibility

Granulocyte Antibody-Mediated Neutropenias and Transfusion Reactions

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