The Seroprevalence of Helicobacter Pylori in A Referral Population of Children in The United States

Chong, Sonny K. F.; Lou, Qinyuan; Zollinger, Terrell W.; Rabinowitz, Simon S.; Jibaly, Rima; Tolia, Vasundhara; Elitsur, Yoram; Gold, Benjamin D.; Rosenberg, Allan J.; Johnson, Austin; Elkayam, O; Rosenthal, Philip; Gilger, Mark A.; Li, B.U.K; Peacock, Jeffrey

doi:10.1111/j.1572-0241.2003.07683.x

Cited by 44 publications

(34 citation statements)

References 24 publications

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“…However, in this study, we found that the prevalence of H. pylori infection among children with RAP was three-and-a-half times greater than those without RAP. Similar findings have been reported in Saudi Arabia [37] and the United States [38]. In sub-Saharan Africa, RAP is common in children and helminthiasis is the proven etiology, particularly in low socio-economic settings [39].…”

Section: Discussionsupporting

confidence: 74%

Helicobacter pylori associated with breastfeeding, nutritional status and recurrent abdominal pain in healthy Nigerian children

Senbanjo

Oshikoya

Njokanma

2014

J Infect Dev Ctries

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Introduction: There is limited knowledge about the associations of Helicobacter pylori (H. pylori) infections in developing countries. This study aimed to determine the current prevalence and associations of H. pylori infection with breastfeeding practices, nutritional status, and recurrent abdominal pain (RAP) in a group of apparently healthy children and adolescents in Lagos, Nigeria. Methodology: This was a prospective hospital-based study conducted at the Lagos State University Teaching Hospital that involved 118 children who came to the hospital for routine pediatric care. Seroprevalence status of the children was determined by measuring immunoglobulin G antibodies against H. pylori using enzyme-linked immunosorbent assay (ELISA). Results: Seventy-five (63.6%) children were seropositive for H. pylori. The prevalence of H. pylori infection increased significantly from 40.4% in children less than five years of age to 85.1% at six to ten years of age (χ 2 = 20.9, p < 0.001). H. pylori infection was associated with low social class (OR = 3.24; 95% CI = 1.20-8.23, p = 0.016) and with RAP (OR = 3.47; 95% CI = 1.55-7.79, p = 0.002), but no association was observed with exclusive breastfeeding, duration of breastfeeding, and under-nutrition. Conclusions: The prevalence of H. pylori infection is high, particularly among children from low socioeconomic backgrounds in Lagos, Nigeria. It is associated with RAP. The effect of this infection on children's health requires further studies.

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Section: Discussionsupporting

confidence: 74%

Helicobacter pylori associated with breastfeeding, nutritional status and recurrent abdominal pain in healthy Nigerian children

Senbanjo

Oshikoya

Njokanma

2014

J Infect Dev Ctries

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“…11,[26][27][28] However, the association of recurrent abdominal pain (RAP) and H. pylori is still debatable and other studies have reported an association between the two. 29,30 On the other hand, there is evidence against this association. First, if this association were true then H. pylori should have been seen more frequently in RAP cases than in controls.…”

Section: It Is Not Yet Clear Whether the Difference In Anthropometry mentioning

confidence: 90%

Helicobacter pylori and recurrent abdominal pain in children: Is there any relation?

KhM²,

Ma³

2012

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“…5 years) [2] . However, this prevalence is quite elevated (ranging from 22 to 45%) also in developed countries, when a population of symptomatic children is considered [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Usefulness of a Serological Panel Test in the Assessment of Gastritis in Symptomatic Children

Angelis¹,

Cavallaro

Maffini³

et al. 2007

Dig Dis

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Background: Non-invasive methods are advisable for the detection of Helicobacter pylori-related chronic gastritis in pediatric patients. Serum pepsinogens I and II (sPGII and sPGII), gastrin-17 (G-17) and anti-H. pylori antibodies (IgG-Hp) have been proposed as a ‘serological gastric biopsy’. Aim: To assess H. pylori infection and to evaluate gastric mucosa status in a pediatric population by means of serological parameters such as sPGI, sPGII, G-17 and IgG-Hp. Methods: 45 consecutively children evaluated for upper gastrointestinal symptoms were analyzed. All children were submitted to upper gastrointestinal endoscopy with biopsies. Serum samples were analyzed for IgG-Hp, sPGII, sPGI and G-17 (Biohit, Helsinki, Finland). Results: 18 children had H. pylori-related mild or moderate non-atrophic chronic gastritis. They presented significantly higher mean levels of sPGII and of IgG-Hp than negative ones, eitherunder or up to 10 years. sPGI showed significantly increased levels in H. pylori-positive patients only over 10 years. G-17 levels were not different between H. pylori-positive and -negative ones. The best cut-offs of IgG-Hp, sPGII and of product IgG-Hp·sPGII, to identify H. pylori infection, were 30 IU/l, 9 µg/l, and 241 IU/l·µg/l, respectively. The product IgG-Hp·sPGII identified H. pylori infection with a 100% sensitivity, 92% specificity, 90% positive predictive value and 100% negative predictive value. IgG-Hp and IgG-Hp showed a correlation (r = 0.94; p < 0.001). Conclusions: Combined analysis of sPGII and IgG-Hp antibody levels could be recommended as a non-invasive panel for the assessment of H. pylori-related histological alterations of gastric mucosa in childhood.

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The Seroprevalence of Helicobacter Pylori in A Referral Population of Children in The United States

Abstract: The H. pylori seropositivity rate of GI referral children with symptoms of abdominal pain was significantly higher. H. pylori infection in early childhood was found to be associated primarily with the child's household size and socioeconomic status.

Cited by 44 publications

References 24 publications

Helicobacter pylori associated with breastfeeding, nutritional status and recurrent abdominal pain in healthy Nigerian children

Helicobacter pylori associated with breastfeeding, nutritional status and recurrent abdominal pain in healthy Nigerian children

Helicobacter pylori and recurrent abdominal pain in children: Is there any relation?

Usefulness of a Serological Panel Test in the Assessment of Gastritis in Symptomatic Children

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