The Seroprevalence of Human Cystic Echinococcosis in Iran: A Systematic Review and Meta-Analysis Study

Abstract

Human cystic echinococcosis (HCE), a zoonotic infection of the larval stage of Echinococcus granulosus, has high effect on public health in human population all around the world. Iran is one of the most important endemic areas in the Middle East. This systematic review and meta-analysis was performed to evaluate the seroprevalence of HCE in Iranian population. An electronic search for articles from 1985 until April 2015 was performed using data bases PubMed, Scopus, Google Scholar, Magiran, IranMedex, Iran Doc, and Scientific Information Database (SID) both in English and in Persian. A random-effects meta-analysis was used to combine results from individual studies. The information was analyzed by STATA version 11.1. A total of 33 articles met our eligibility criteria and were included in a meta-analysis. The pooled estimate of the prevalence of HCE based on random-effects model was estimated 6.0% (95% CI: 4.0%, 7.0%). The prevalence of the disease significantly increased with age and prevalence rate in males was significantly lower than females (p < 0.001). The using of CIE or CCIEP method was also significantly greater than the other methods (p < 0.001). There was a publication bias in prevalence of studies. HCE is highly prevalent in Iran. Public education for preventive strategies and finally reducing transmission of the parasite and infection in population is needed.

Seroprevalence of Hydatidosis in Kaboodarahang, Hamadan Province, Iran, in 2016 - 2017

“…Our study showed that the seroprevalence of the disease was low, similar to some other studies. Farrokhzad et al in 2004 reported a rate of 0.2% in Tehran by the IFA method (10) while Zibaei recorded an amazing rate of 15.4% in Khorramabad in 2013 (2). Some studies showed that the most prevalence of the disease was obtained in the west and southwest of Iran with the highest prevalence obtained in Lorestan (13) and we gained the same data in our study.…”

“…Other variables evaluated in our study were age, gender, and occupation. Our data showed no significant differences between the seroprevalence of CE and the above mentioned variables, which is consistent with the study of Rokni in Qom (15) although Nourjah et al in 2004 showed that women had a higher prevalence of hydatid cyst and underwent more surgery (13) and the study of Shafiei et al indicated that the seroprevalence of hydatid cyst was higher in the middle-aged group, which are not in agreement with our study (2). Another study in Zanjan showed that the infection is more common among over 50-yearsold (16).…”

“…It can be transmitted by infected feces of dogs via soil, vegetables, water, food, etc. (1,2). The disease is widely distributed in regions where sheep rearing is a major industry.…”

Seroepidemiological Study of Hydatid Cyst Using AgB by ELISA in Patients Admitted to Central Laboratory of Baqiyatallah Hospital

“…19 Many investigations were shown that hydatid cyst usually occurs in adulthood/ middle age and was generally increased with the increase of the age. 14,20,21 In the present study, although the most frequent positive response was observed in 40-79 (85.72%) age group, there is not any significant differences between age and seroprevalence of the disease.…”

“…[4][5][6] Moreover, it is prevalent in final and intermediate hosts in different part of Iran. [7][8][9][10][14][15][16][17][18] Our results showed that 0.8% of participants were seropositive for hydatid cyst disease. The assessment of many studies demonstrated that the seroprevalence of CE varied between 0.22% in Tehran 18 and 15.4% in Khoramabad.…”