The seroprevalence of <i>Helicobacter pylori</i> and nitric oxide in acne rosacea

Gürer, Mehmet Ali; Erel, Arzu; Erbaş, Deniz; Çağlar, Kayhan; Atahan, C.

doi:10.1046/j.1365-4362.2002.01452.x

Cited by 39 publications

(29 citation statements)

References 10 publications

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“…Several reports showed seropositivity to H. pylori in rosacea individuals [68]. Eradication therapy for gastric H. pylori infection showed preferable outcome for rosacea symptoms though it is not clear if the improve of rosacea is due to H. pylori eradication [69-71].…”

Section: Microbesmentioning

confidence: 99%

“…Eradication therapy for gastric H. pylori infection showed preferable outcome for rosacea symptoms though it is not clear if the improve of rosacea is due to H. pylori eradication [69-71]. H. pylori produces ROS [72-74] and rosacea individuals showed higher ROS including NO (nitric oxide) in plasma than controls [68, 75]. H. pylori induce cytokine release through TLR2 and TLR4 in gastric epithelial cells [76, 77].…”

Section: Microbesmentioning

confidence: 99%

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The molecular pathology of rosacea

Yamasaki

Gallo

2009

Journal of Dermatological Science

247

241

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Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation. Until recently, the pathophysiology of this disease has been poorly understood and limited to descriptions of factors that exacerbate or improve this disorder. Recent molecular studies suggest that an altered innate immune response is involved in the pathogenesis of the vascular and inflammatory disease seen in patients with rosacea. These findings may help explain the benefits of current treatments and suggest new therapeutic strategies helpful for alleviating this disease. This article discusses the possible molecular mechanisms for the pathogenesis of rosacea from current clinical observations and laboratory research.

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Section: Microbesmentioning

confidence: 99%

Section: Microbesmentioning

confidence: 99%

The molecular pathology of rosacea

Yamasaki

Gallo

2009

Journal of Dermatological Science

247

241

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“…Eradication of H. pylori has been occasionally associated with an improvement of rosacea symptoms [42, 43, 44]. An increased prevalence of anti- H.-pylori antibodies was found in rosacea patients [44, 45, 46]. However, subsequent studies have clearly demonstrated that there is no significant difference in the seroprevalence of H. pylori infection among rosacea patients and healthy subjects [1, 47].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Rosacea: An Update

Buechner¹

2005

Dermatology

119

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Rosacea is a common chronic cutaneous disorder of unknown etiology which occurs most commonly in middle-aged individuals. Cutaneous manifestations include transient or persistent facial erythema, telangiectasia, edema, papules and pustules that are usually confined to the central portion of the face. The National Rosacea Society’s Expert Committee on the Classification and Staging of Rosacea identified four subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous and ocular. Recently, a standard grading system for assessing gradations of the severity of rosacea has been reported. Little is known about the cause of rosacea. Genetic, environmental, vascular, inflammatory factors and microorganisms such as Demodex folliculorum and Helicobacter pylori have been considered. Topical metronidazole and azelaic acid have been demonstrated to be effective treatments for rosacea. Severer or persistent cases may be treated with oral metronidazole, tetracyclines or isotretinoin.

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“…Helicobacter pylori (HP) is the primary cause of gastritis and a major contributor to peptic ulcer disease. Recently, there have been several investigations suggesting a possible etiologic role for HP in rosacea 2–8 . Some of these investigations have shown that the prevalence of HP infection in patients with rosacea is higher than that of control subjects 4–6 or average values, 7 and others have reported that HP eradication treatment reduces the severity of rosacea 2,3,6,8 …”

Section: Introductionmentioning

confidence: 99%

“…How HP is related to rosacea remains unclear; however, it has been shown that HP can increase serum or tissue levels of nitrous oxide (NO), 9–11 a free radical, which has been found to be important in a number of different physiological processes in the skin, including vasodilatation, inflammation, and immunomodulation 12,13 . Thus, it has been postulated that NO produced by HP might cause the flushing and erythema associated with rosacea, 14 or have a pathogenic role in rosacea inflammation 5 . This has not yet been proven, however.…”

Section: Introductionmentioning

confidence: 99%