The seroprevalence of parvovirus B19 infection in pregnant women in Sudan

Adam, Omer; Makkawi, T.; Reber, Ulrike; Kirberg, Heike; Eis‐Hübinger, Anna Maria

doi:10.1017/s0950268814000600

Cited by 22 publications

(28 citation statements)

References 44 publications

(71 reference statements)

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“…B19V infection is common worldwide, showing regional epidemiological differences, with generally over one-half of the adult population having been exposed. The prevalence of B19V-specific antibodies in the population is age dependent, increasing from 2 to 20% in children Ͻ5 years old to 15 to 40% in children 5 to 18 years old and to 40 to 80% in the adult population, depending on both the assays used and the population (214)(215)(216)(217)(218)(219)(220)(221)(222)(223)(224)(225). Seroprevalence, however, is much lower in some isolated areas, such as the Rodriguez Islands and among some Brazilian tribes, with adult seroprevalences of only 2 to 10% (226,227).…”

Section: Epidemiology Virus Prevalence and Transmissionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Epidemiology Virus Prevalence and Transmissionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…Also, B19 IgG antibodies detected in 46.6% and IgM antibodies in 2.25% of different age groups of childbearing women in Makah (14). B19 IgG seroprevalence was 61.4%, with one subject positive for IgM in Sudan (15). In another study, of the 231 women in Nigeria, 45 (20%) were positive for parvovirus B19 IgG, 10 (4%) were positive for parvovirus B19 IgM (2).…”

Section: Discussionmentioning

confidence: 92%

“…But, in our study B19 seroprevalence was not correlated with job, education, place of residence, history of illness, medications, pregnancy, history of abortion, and blood transfusion. In one study parvovirus B19 IgG seroprevalence was correlated with multigravidity (15). In other study the only variable associated with acquisition of IgG antibodies to parvovirus B19 was number of pregnancies more than one (20).…”

Section: Discussionmentioning

confidence: 93%

Seroprevalence of Parvovirus B19 Antibodies in Young Women, Sanandaj, Iran

2013

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Background and Aims: Human parvovirus B19 may transmit to the fetus via the placenta during pregnancy and cause serious complications such as severe fetal anemia, non-immune hydrops fetalis, and even intrauterine fetal death. The aim of this study was to determine the seroprevalence of parvovirus B19 antibodies among young women, Sanandaj, Iran. Materials and Methods: Ninety young women (15-40 years old) referring to clinical laboratory, Sanandaj, Iran, from January 2013 until June 2014 participated in this cross sectional study. In a questionnaire demographic data including age, job, education, place of residence, and history of illness, medications, pregnancy, history of abortion, and blood transfusion were collected. Women's sera were screened for parvovirus B19 IgM and IgG antibodies using ELISA test. The collected data and ELISA results were entered to SPSS statistical software and analyzed using t-test, one-way ANOVA with Tukey post hoc and Chisquire. Results: Prevalence of parvovirus B19 IgG and IgM antibodies were 46.7% and 3.3%, respectively in our study population. There were no association between parvovirus antibodies and the demographic variables using t-test, and one-way ANOVA with Tukey post hoc and Chi-squire. Conclusion: We found that more than fifty percent of the subjects were susceptible to parvovirus B19. Also, IgM antibody was positive in 3.3% of women, indicates that there is an active transmission of the virus in our population. Therefore, if this infection occurs during pregnancy may be harmful to the fetus. Paying more attention is needed to determine the B19 immunity, especially in young women ready for marriage and pregnancy.

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“…9 The peak incidence of B19V-associated hydrops fetalis is between 17 and 24 weeks of gestation. 10,11 Testing maternal serum for IgM/IgG antibodies against parvovirus B19, and DNA detection by PCR can confirm maternal infection. Among the total number of samples analyzed in our study, three were diagnosed with hydrops fetalis, and all three were positive for infection by parvovirus B19.…”

Section: Discussionmentioning

confidence: 99%

Genotype 1 of human parvovirus B19 in clinical cases

Oliveira

Afonso

Curti

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction: Virus surveillance strategies and genetic characterization of human parvovirus B19 (B19V) are important tools for regional and global control of viral outbreak. In São Paulo, Brazil, we performed a study of B19V by monitoring the spread of this virus, which is an infectious agent and could be mistakenly reported as a rash and other types of infection. Method: Serum samples were subjected to enzyme immunoassay, real time polymerase chain reaction, and sequencing. Results: From the 462 patients with suspected cases of exanthematic infections, the results of the 164 serum samples were positive for B19V immunoglobulin M. Among these cases, there were 38 patients with erythema infections and B19--associated with other infections such as encephalitis, hydrops fetalis, chronic anemia, hematological malignancies. These samples were sequenced and identified as genotype 1. Conclusion: This study showed patients with infections caused by B19V and sequencing genotype 1. Continuous monitoring is necessary to detect all known genotypes, and the emergence of new genotypes of these viruses for case management in public health control activities.

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The seroprevalence of parvovirus B19 infection in pregnant women in Sudan

Cited by 22 publications

References 44 publications

Human Parvoviruses

Human Parvoviruses

Seroprevalence of Parvovirus B19 Antibodies in Young Women, Sanandaj, Iran

Genotype 1 of human parvovirus B19 in clinical cases

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