The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant

Jobe, Phillip C.; Browning, Ronald A.

doi:10.1016/j.yebeh.2005.07.014

Cited by 150 publications

(128 citation statements)

References 148 publications

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“…However, SSRIs, one of the most widely used class of antidepressants seem to be relatively safe in this regard. 3,4 They, in fact have shown anticonvulsant action in some animal models of epilepsy though some uncontrolled clinical case studies have shown them to increase seizure frequency in patients with depression. 5 Another major drawback of the commonly used anticonvulsants is the adverse reactions encountered during chronic use.…”

Section: Introductionmentioning

confidence: 99%

Fluoxetine enhances maximal electroshock seizure threshold in Albino rat model when compared to phenytoin

Gangopadhyay

Mandal

Keshri

2017

Int J Basic Clin Pharmacol

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Background: Individuals with epilepsy have a higher incidence of psychiatric disorders than person without epilepsy. Epidemiological studies have shown that the co-morbidity of epilepsy and depression to be high as 50%. The conventional anti-depressants are believed to lower the seizure threshold making it difficult to treat the co-morbid depression, but animal studies have shown SSRIs, a common anti-depressant, to have anti-convulsant properties. So, we propose to study the anticonvulsant effects of fluoxetine, a SSRI, in albino rats against maximal electroshock seizure and to compare against a standard antiepileptic drug phenytoin.Methods: The anticonvulsant effect of fluoxetine was observed in model of maximal electroconvulsive seizure threshold in albino rats. The animals were divided into 3 groups having 6 animals each, receiving distilled water, fluoxetine and phenytoin respectively. The drugs were given orally, and the effect was observed on day 7, 14 and 21. Tonic hind-limb extension was taken as the parameter of electroshock seizure. The effects were compared against a standard anti-seizure drug phenytoin.Results: Fluoxetine showed significant elevation of the seizure threshold following 14 days of administration (P value 0.031). The effect was comparable to phenytoin with no significant difference after 7, 14 and 21 days of treatment (P-value 0.485, 0.699 and 0.818 respectively) though phenytoin showed significant anti-seizure effect since day 7 of treatment.Conclusions: Fluoxetine showed significant anti-seizure activity against electroconvulsive seizure in albino rats.

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Section: Introductionmentioning

confidence: 99%

Fluoxetine enhances maximal electroshock seizure threshold in Albino rat model when compared to phenytoin

Gangopadhyay

Mandal

Keshri

2017

Int J Basic Clin Pharmacol

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“…There had been investigations defending this anticonvulsant effect for years in which the authors hypothesized different mechanisms to explain the anticonvulsant role of TcAs [31]- [33]. Curiously Jobe and Browning [34] published an article whose title alone, "The serotoninergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant", summarizes all our argumentations on this topic. More recently other authors [35] [36] have recently highlighted the anticonvulsant role of second-generation antidepressants.…”

Section: Anticonvulsant Effect Of Dasmentioning

confidence: 99%

Psychiatric Symptoms of Epileptic Nature: An Old Hypothesis in Light of Current Psychopharmacologic Advances

Alvarez-Rodriguez¹

2015

OJPsych

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This paper analyses a hypothesis according to which many positive psychiatric symptoms should be interpreted as symptoms of epileptic nature. When we first raised this proposition, almost fifteen years ago, it was inconsistent with the widespread conviction among psychiatrists that psychopharmacological drugs used to suppress psychiatric symptoms were proconvulsant. But lately, there have appeared numerous neuroscientific investigations that defend the anticonvulsant effect of most psychopharmacological drugs, hence supporting our hypothesis. We have carried out bibliographical reviews in search of the pro-or anticonvulsant role of these substances, particularly lithium, selective serotonin reuptake inhibitors, dual antidepressants, and antipsychotic drugs. These researches show abundant evidence regarding the anticonvulsant action of these substances, a fact that contributes to a better comprehension of paradoxical relationship between epilepsy and psychoses.

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“…I MR-og PET-studier er det ved både epilepsi og depresjoner funnet morfologiske og metabolske endringer ikke bare temporalt, men også frontalt (30). Studier av dyremodeller av epilepsi har vist at økt serotonerg aktivitet kan ha antikonvulsive effekter (31), og hos epilepsipasienter kan antidepressiver av typen selektive serotoninreopptakshemmere (SSRI) ha et visst antikonvulsivt potensial (32), samtidig som den positive psykotrope effekten av lamotrigin, karbamazepin og valproat kan vaere formidlet via økte serotoninnivåer. Man har også spekulert på om den antiepileptiske og den antidepressive effekten av vagusnervestimulering er formidlet gjennom økt noradrenerg og serotonerg aktivitet (33).…”

Section: Flere Patofysiologiske Fellestrekkunclassified

Epilepsi og depresjon

Henning¹,

Nakken²

2011

Tidsskriftet

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The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant

Cited by 150 publications

References 148 publications

Fluoxetine enhances maximal electroshock seizure threshold in Albino rat model when compared to phenytoin

Fluoxetine enhances maximal electroshock seizure threshold in Albino rat model when compared to phenytoin

Psychiatric Symptoms of Epileptic Nature: An Old Hypothesis in Light of Current Psychopharmacologic Advances

Epilepsi og depresjon

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