The serotonergic system is involved in feeding inhibition by pymetrozine. Comparative studies on a locust (Locusta migratoria) and an aphid (Myzus persicae)

Kaufmann, L.; Schürmann, Franz; Yiallouros, Maria; Harrewijn, P.; Kayser, Hartmut

doi:10.1016/j.cca.2004.08.007

Cited by 48 publications

(68 citation statements)

References 35 publications

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“…The presence of motoneuron discharges and muscle activity during active movement demonstrates that neuromuscular transmission and muscle function remained basically unimpaired by pymetrozine, in agreement with previous results (Kaufmann et al, 2004). This had also been illustrated by our electromyographic (extensor and flexor tibiae muscles), motor nerve (nerves 3B2c, 5B1c) and movement recordings (see above).…”

Section: Intracellular Motoneuron Recordingssupporting

confidence: 92%

“…Kaufmann et al, 2004; see also Fig.·4A,B). We therefore wanted to determine whether or not this same threshold is valid for the effects on the fCO alone -which, if true, would support the interpretation that fCO effects are an important cause of the behavioural consequences of pymetrozine application (e.g.…”

Section: Sensory Coding By the Fcomentioning

confidence: 77%

“…Again, both pymetrozine and phenyl analogue were used, the phenyl analogue only being at 10 -5 ·mol·l -1 . Usual pymetrozine concentrations were 10 -6 to 10 -7 ·mol·l -1 , although the highest and lowest applied concentrations were 10 -5 ·mol·l -1 and 10 -9 ·mol·l -1 when determining threshold concentrations ( Fig.·7; see also Kaufmann et al, 2004). Minor dilution may have occurred due to residual saline in the preparation.…”

Section: Application Of Compoundsmentioning

confidence: 93%

“…Stock solution of insecticide was 10·mmol·l -1 in DMSO; it was diluted 1:5 in water before injection. The final dose of insecticide in the insect body was 0.5· g·g -1 body mass (Kaufmann et al, 2004). In dissected preparations, the saline (Usherwood and Grundfest, 1965) in the body cavity was replaced with saline containing the desired concentration of the compound.…”

Section: Application Of Compoundsmentioning

confidence: 99%

“…During studies concerned with the basic mode of pymetrozine action, it was observed that the locust Locusta migratoria, though not a target pest for the field use of pymetrozine, is also sensitive to this compound. This is illustrated by feeding inhibition, as in aphids, but also by unique intoxication symptoms (Kaufmann et al, 2004). As a response to injected or food-applied pymetrozine, locusts raise their legs with the femur-tibia joints almost fully extended (Fig.·2C).…”

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confidence: 97%

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The insecticide pymetrozine selectively affects chordotonal mechanoreceptors

Ausborn

Wolf

Mader

et al. 2005

Journal of Experimental Biology

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Pymetrozine is a neuroactive insecticide but its site of action in the nervous system is unknown. Based on previous studies of symptoms in the locust, the feedback loop controlling the femur-tibia joint of the middle leg was chosen to examine possible targets of the insecticide. The femoral chordotonal organ, which monitors joint position and movement, turned out to be the primary site of pymetrozine action, while interneurons, motoneurons and central motor control circuitry in general did not noticeably respond to the insecticide. The chordotonal organs associated with the wing hinge stretch receptor and the tegula were influenced by pymetrozine in the same way as the femoral chordotonal organ, indicating that the insecticide affects chordotonal sensillae in general.Pymetrozine at concentrations down to 10 -8 ·mol·l -1 resulted in the loss of stimulus-related responses and either elicited (temporary) tonic discharges or eliminated spike activity altogether. Remarkably, pymetrozine affected the chordotonal organs in an all-or-none fashion, in agreement with previous independent studies. Other examined sense organs did not respond to pymetrozine, namely campaniform sensillae on the tibia and the subcosta vein, hair sensillae of the tegula (type I sensillae), and the wing hinge stretch receptor (type II sensillae).

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Section: Intracellular Motoneuron Recordingssupporting

confidence: 92%

Section: Sensory Coding By the Fcomentioning

confidence: 77%

Section: Application Of Compoundsmentioning

confidence: 93%

Section: Application Of Compoundsmentioning

confidence: 99%

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confidence: 97%

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