The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635

Stein, P.; Savli, Markus; Wadsak, Wolfgang; Mitterhauser, Markus; Fink, Martin; Spindelegger, Christoph; Mien, Leonhard‐Key; Moser, Ulrike; Dudczak, Robert; Kletter, Kurt; Kasper, Siegfried; Lanzenberger, Rupert

doi:10.1007/s00259-008-0850-x

Cited by 57 publications

(45 citation statements)

References 61 publications

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“…Twenty-eight healthy subjects participated in this study (mean age ± SD = 26.5 ± 6.8 y, 17 female), who in part also served as control subjects in previous studies (57,(70)(71)(72)(73) (SI Materials and Methods). This project was approved by the Ethics Committee of the Medical University of Vienna and the General Hospital of Vienna.…”

Section: Methodsmentioning

confidence: 99%

Differential modulation of the default mode network via serotonin-1A receptors

Hahn

Wadsak

Windischberger

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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114

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Reflecting one's mental self is a fundamental process for evaluating the personal relevance of life events and for moral decision making and future envisioning. Although the corresponding network has been receiving growing attention, the driving neurochemical mechanisms of the default mode network (DMN) remain unknown. Here we combined positron emission tomography and functional magnetic resonance imaging to investigate modulations of the DMN via serotonin-1A receptors (5-HT 1A ), separated for 5-HT autoinhibition (dorsal raphe nucleus) and local inhibition (heteroreceptors in projection areas). Using two independent approaches, regional 5-HT 1A binding consistently predicted DMN activity in the retrosplenial cortex for resting-state functional magnetic resonance imaging and the Tower of London task. On the other hand, both local and autoinhibitory 5-HT 1A binding inversely modulated the posterior cingulate cortex, the strongest hub in the resting human brain. In the frontal part of the DMN, a negative association was found between the dorsal medial prefrontal cortex and local 5-HT 1A inhibition. Our results indicate a modulation of key areas involved in self-referential processing by serotonergic neurotransmission, whereas variations in 5-HT 1A binding explained a considerable amount of the individual variability in the DMN. Moreover, the brain regions associated with distinct introspective functions seem to be specifically regulated by the different 5-HT 1A binding sites. Together with previously reported modulations of dopamine and GABA, this regional specialization suggests complex interactions of several neurotransmitters driving the default mode network.functional connectivity | resting-state networks | neurotransmitter modulation

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Section: Methodsmentioning

confidence: 99%

Differential modulation of the default mode network via serotonin-1A receptors

Hahn

Wadsak

Windischberger

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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114

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“…In total, PET data from 57 participants from previous work Spindelegger et al, 2008;Stein et al, 2008;Fink et al, 2009;Witte et al, 2009) were used for this retrospective pooled study. Within our patient group, we included 21 medication-free subjects (18 males) between 22 and 56 years of age [mean age (ϮSD), 30.3 Ϯ 7.9 years] with social anxiety (n ϭ 16) or panic disorder (n ϭ 5).…”

Section: Methodsmentioning

confidence: 99%

“…To evaluate the association of 5-HT 1A binding between autoreceptors and heteroreceptors, a voxel-wise linear regression analysis was performed in SPM5 (Wellcome Trust Centre for Neuroimaging, London, UK; http://www.fil.ion.ucl.ac.uk/spm/) for each group separately (i.e., healthy subjects at baseline as well as patients before and after SSRI treatment). Here, the BP ND values of the DRN ROI served as the regressor, and the whole-brain voxel-wise 5-HT 1A binding maps served as the dependent variable, controlling for sex because of controversial results (Jovanovic et al, 2008;Stein et al, 2008). The resulting t maps were then transformed into R maps representing the correlation coefficient of the regression model [p Ͻ 0.05, corrected for multiple comparisons using the false discovery rate (FDR)] with the VBM toolbox 5.1 (http://dbm.neuro.uni-jena.de/vbm/).…”

Section: Methodsmentioning

confidence: 99%

Escitalopram Enhances the Association of Serotonin-1A Autoreceptors to Heteroreceptors in Anxiety Disorders

Hahn¹,

Lanzenberger²,

Wadsak³

et al. 2010

J. Neurosci.

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“…Higher 5-HT 1A receptor binding has been described in women in some (Costes et al, 2005;Jovanovic et al, 2008) but not all studies (Cidis Meltzer et al, 2001;Stein et al, 2008). Cerebral serotonin-transporter binding has not been consistently shown to depend on sex (Jovanovic et al, 2008;Kalbitzer et al, 2009;Meyer et al, 2004).…”

Section: Introductionmentioning

confidence: 98%

Age and sex effects on 5-HT₄ receptors in the human brain: A [¹¹C]SB207145 PET study

Madsen

Haahr

Marner

et al. 2011

J Cereb Blood Flow Metab

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Experimental studies indicate that the 5-HT 4 receptor activation influence cognitive function, affective symptoms, and the development of Alzheimer's disease (AD). The prevalence of AD increases with aging, and women have a higher predisposition to both AD and affective disorders than men. This study aimed to investigate sex and age effects on 5-HT 4 receptor-binding potentials in striatum, the limbic system, and neocortex. Positron-emission tomographic scans were conducted using the radioligand [ 11 C]SB207145 in a cohort of 30 healthy subjects (mean age 44 years; range 20 to 86 years; 14 men and 16 women). The output parameter, BP ND , was modeled using the simplified reference tissue model, and partial volume correction was performed with the Muller-Gartner method. A decline with age of 1% per decade was found only in striatum. Women had a 13% lower 5-HT 4 receptor binding in the limbic system. The lower limbic 5-HT 4 receptor binding in women supports a role for 5-HT 4 receptors in the sex-specific differences in emotional control and might contribute to the higher prevalence of affective diseases and AD in women. The relatively stable 5-HT 4 receptor binding with aging contrasts others in subtypes of receptors, which generally decrease with aging.

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The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635

Cited by 57 publications

References 61 publications

Differential modulation of the default mode network via serotonin-1A receptors

Differential modulation of the default mode network via serotonin-1A receptors

Escitalopram Enhances the Association of Serotonin-1A Autoreceptors to Heteroreceptors in Anxiety Disorders

Age and sex effects on 5-HT₄ receptors in the human brain: A [¹¹C]SB207145 PET study

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The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635

Cited by 57 publications

References 61 publications

Differential modulation of the default mode network via serotonin-1A receptors

Differential modulation of the default mode network via serotonin-1A receptors

Escitalopram Enhances the Association of Serotonin-1A Autoreceptors to Heteroreceptors in Anxiety Disorders

Age and sex effects on 5-HT4 receptors in the human brain: A [11C]SB207145 PET study

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Age and sex effects on 5-HT₄ receptors in the human brain: A [¹¹C]SB207145 PET study