The serotonin transporter polymorphism (5-HTTLPR) and coping strategies influence successful emotion regulation in an acute stress situation: Physiological evidence

Plieger, Thomas; Melchers, Martin; Vetterlein, Annabel; Görtz, Janina; Kuhn, Sarah Anne Kezia; Ruppel, Melissa; Reuter, Martin

doi:10.1016/j.ijpsycho.2017.02.006

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Studies with very short trial duration tend to report an increase in skin conductance, whereas studies with longer or extremely long trial durations tend to report a decrease in skin conductance. However, we acknowledge that our analysis did not allow to differentiate for example between studies that assessed skin conductance averages but eliminated the tonic parts (Hallam et al, 2015;Plieger et al, 2017) and studies that assessed skin conductance level without separating the phasic from the tonic responses. We encourage future researcher to use similar research methodology and terminology as suggested by the committee report on publication recommendations (Boucsein et al, 2012) to make studies more comparable in the future.…”

Section: Discussionmentioning

confidence: 99%

Psychophysiological Effects of Downregulating Negative Emotions: Insights From a Meta-Analysis of Healthy Adults

et al. 2020

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Assessing psychophysiological responses of emotion regulation is a cost-efficient way to quantify emotion regulation and to complement subjective report that may be biased. Previous studies have revealed inconsistent results complicating a sound interpretation of these findings. In the present study, we summarized the existing literature through a systematic search of articles. Meta-analyses were used to evaluate effect sizes of instructed downregulation strategies on common autonomic (electrodermal, respiratory, cardiovascular, and pupillometric) and electromyographic (corrugator activity, emotion-modulated startle) measures. Moderator analyses were conducted, with moderators including study design, emotion induction, control instruction and trial duration. We identified k = 78 studies each contributing multiple sub-samples and performed 23 meta-analyses for combinations of emotion regulation strategy and psychophysiological measure. Overall, results showed that effects of reappraisal and suppression on autonomic measures were highly inconsistent across studies with rather small mean effect sizes. Electromyography (startle and corrugator activity) showed medium effect sizes that were consistent across studies. Our findings highlight the diversity as well as the low level of standardization and comparability of research in this area. Significant moderation of effects by study design, trial duration, and control condition emphasizes the need for better standardization of methods. In addition, the small mean effect sizes resulting from our analyses on autonomic measures should be interpreted with caution. Findings corroborate the importance of multi-channel approaches.

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Section: Discussionmentioning

confidence: 99%

Psychophysiological Effects of Downregulating Negative Emotions: Insights From a Meta-Analysis of Healthy Adults

et al. 2020

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“…Fox et al 2009), while also showing the potential role of the short variant of 5-HTTLPR as a risk allele, for example, regarding depression (Caspi et al 2003) or anxiety (Lesch et al 1996). Moreover, in several studies and meta-analyses, the moderating role of 5-HTTLPR is highlighted, for example, in terms of moderating emotional behavior and changes in marital satisfaction (Haase et al 2013), stress and depression (Karg et al 2011), or coping strategies and emotion regulation (Plieger et al 2017). A recent meta-analysis, however, concluded that the 5-HTTLPR by stress interaction on depression must be of a modest effect size and only observable in limited situations (Culverhouse et al 2018).…”

Section: Discussionmentioning

confidence: 99%

The Molecular Genetics of Life Satisfaction: Extending Findings from a Recent Genome-Wide Association Study and Examining the Role of the Serotonin Transporter

Lachmann¹,

Doebler

Sindermann³

et al. 2020

J Happiness Stud

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In a recent genome-wide association study (GWAS), three polymorphisms (rs3756290, RAPGEF6; rs2075677, CSE1L; rs4958581, NMUR2) were suggested as potentially being related to subjective-well-being and life satisfaction. Additionally, associations between the 5-HTTLPR polymorphism (serotonin transporter) and subjective well-being have been reported in other previous studies. In the current study, we therefore sought to further investigate the findings of the GWAS and examine the association between 5-HTTLPR and subjective well-being. A total of 1174 participants (821 females) were recruited and asked to provide information on their demographics, life satisfaction, and positive affect. All participants provided a genetic sample. We found associations between one SNP derived from the GWAS (rs4958581, NMUR2) and life satisfaction. We also replicated findings involving 5-HTTLPR and life satisfaction, but only for the housing, leisure and family life satisfaction variables, and not for overall life satisfaction or positive affect. Our study underlines that research investigating complex traits in the field of behavioral genetics is challenging due to their (a) pleiotropic and (b) polygenic effects, resulting in tiny effect sizes of each marker investigated. The current study also highlights the importance of investigating genetic markers of distinct areas of life satisfaction.

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“…Studies revealed characteristic changes in, for instance, heart period (Driscoll et al, 2009;Kalisch et al, 2005), skin conductance (Sheppes et al, 2009;Urry, 2010), and facial muscle activity (Ray et al, 2010;Urry, 2010), indicating that successful reappraisal results in reduced physical activation. In detail, reduced skin conductance responses have been found during down-regulation, and enhanced skin conductance responses during upregulation of negative emotions (Kim & Hamann, 2012;Plieger et al, 2017;Urry, 2009). Whereas skin conductance is sensitive to changes in arousal, heart period and facial muscle activity are sensitive to changes in valence (Lang et al, 1998).…”

Section: Peripheral Physiological Parametersmentioning

confidence: 99%

“…However, these studies show several limitations: They either merely focused on the reinterpretation type of reappraisal (Urry, 2010), or on suppression (Dan-Glauser & Gross, 2011;Jackson et al, 2000), or on a mixed form of reappraisal and suppression (Plieger et al, 2017), or on a more general instruction to simply "decrease" negative emotions (Driscoll et al, 2009;Kim & Hamann, 2012;Ray et al, 2010;Urry, 2009). As far as we know, there are only two studies that investigated the skin conductance response during detachment: one study compared the effects of brain stimulation (tDCS) (Feeser et al, 2014), and the other investigated detachment during emotional film clips (Sheppes et al, 2009).…”

Section: Peripheral Physiological Parametersmentioning

confidence: 99%

Individual differences in inhibitory control are not related to emotion regulation

Gärtner¹,

Jawinski²,

Strobel³

2021

Preprint

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Although cognitive control and emotional control have been proposed to rely on similar processes, their specific relationship is not well understood. Given that reappraisal to down-regulate negative emotions requires inhibiting or limiting the expression of a prepotent appraisal of a situation in favor of selecting an alternative appraisal, inhibitory control seems to be a particularly relevant process. However, inconsistent findings on the relationship between inhibitory control and reappraisal ability have been reported, likely because of the application of single task measures in relatively small samples. Therefore, this study examined the relationship between both control processes using a powerful within-subject design in a large sample (N = 190) and by applying a battery of six commonly used inhibitory control tasks. Emotion regulation was measured comprehensively by self-reported habitual use of reappraisal and suppression strategies, by valence and arousal ratings during a reappraisal task and by concurrent physiological measures such as corrugator electromyography (EMG), skin conductance response (SCR), and heart period (HP). Frequentist and Bayesian analyses indicated that inhibitory control was not associated with emotion regulation in our sample of young healthy adults. Furthermore, by implementing a full two-by-two design including a “regulate neutral” condition, the present study provides evidence that domain-general regulation effects need to be separated from domain-specific regulation effects. Finally, compared to HP and SCR, corrugator EMG emerged as a suitable peripheral physiological indicator of regulatory success that was indicative of the regulation of negative emotion.

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The serotonin transporter polymorphism (5-HTTLPR) and coping strategies influence successful emotion regulation in an acute stress situation: Physiological evidence

Cited by 14 publications

References 42 publications

Psychophysiological Effects of Downregulating Negative Emotions: Insights From a Meta-Analysis of Healthy Adults

Psychophysiological Effects of Downregulating Negative Emotions: Insights From a Meta-Analysis of Healthy Adults

The Molecular Genetics of Life Satisfaction: Extending Findings from a Recent Genome-Wide Association Study and Examining the Role of the Serotonin Transporter

Individual differences in inhibitory control are not related to emotion regulation

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