The serum creatinine to cystatin C to waist circumference ratios predicts risk for type 2 diabetes: A Chinese cohort study

Chen, Yinfei; Wen, Weiheng; Mai, Zhiliang; Wang, Ming; Chen, Hong; Sun, Jia

doi:10.1111/1753-0407.13435

Cited by 3 publications

(7 citation statements)

References 46 publications

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“…Previous studies have provided evidence of significant associations between reduced ratios of serum CCR and diminished muscle mass, as well as adverse clinical outcomes in multiple disease conditions ( 24 – 27 ). However, there has been limited investigation into the potential relationship between CCR and bone properties.…”

Section: Discussionmentioning

confidence: 99%

Muscle-origin creatinine-cystatin C ratio is an osteoporosis marker in individuals with normal renal function: evidence from observational and Mendelian randomization analysis

He,

Yang,

Wang

et al. 2024

Front. Endocrinol.

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BackgroundCreatinine-cystatin C ratio (CCR) has been demonstrated as an objective marker of sarcopenia in clinical conditions but has not been evaluated as an osteoporosis marker in individuals with normal renal function.MethodsWe selected 271,831 participants with normal renal function from UK Biobank cohort. Multivariable linear/logistic regression and Cox proportional hazards model were used to investigate the phenotypic relationship between CCR and osteoporosis in total subjects and gender-stratified subjects. Based on the genome-wide association study (GWAS) data, linkage disequilibrium regression (LDSC) and Mendelian randomization (MR) analysis were performed to reveal the shared genetic correlations and infer the causal effects, respectively.ResultsAmongst total subjects and gender-stratified subjects, serum CCR was positively associated with eBMD after adjusting for potential risk factors (all P<0.05). The multivariable logistic regression model showed that the decrease in CCR was associated with a higher risk of osteoporosis/fracture in all models (all P<0.05). In the multivariable Cox regression analysis with adjustment for potential confounders, reduced CCR is associated with the incidence of osteoporosis and fracture in both total subjects and gender-stratified subjects (all P<0.05). A significant non-linear dose–response was observed between CCR and osteoporosis/fracture risk (Pnon-linearity < 0.05). LDSC found no significant shared genetic effects by them, but PLACO identified 42 pleiotropic SNPs shared by CCR and fracture (P<5×10–8). MR analyses indicated the causal effect from CCR to osteoporosis/fracture.ConclusionsReduced CCR predicted increased risks of osteoporosis/fracture, and significant causal effects support their associations. These findings indicated that the muscle-origin serum CCR was a potential biomarker to assess the risks of osteoporosis and fracture.

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Section: Discussionmentioning

confidence: 99%

Muscle-origin creatinine-cystatin C ratio is an osteoporosis marker in individuals with normal renal function: evidence from observational and Mendelian randomization analysis

He,

Yang,

Wang

et al. 2024

Front. Endocrinol.

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“…The results of this longitudinal analysis confirmed the causal relationship between the CCR/WC ratio and SAL. As a novel integrated index of abdominal obesity and muscle mass, this metric has previously been validated as a predictor of type 2 diabetes mellitus incidence [22]. CCR/WC ratios show promise as potential predictive markers for diseases influenced by the combined effects of muscle mass and obesity and could potentially be validated in various other conditions in the future.…”

Section: Discussionmentioning

confidence: 99%

“…The CCR (creatinine clearance rate) is calculated by dividing the creatinine value (mg/dL) by the cystatin C value (mg/L) and then multiplying the result by 100. The CCR/WC ratio is obtained by dividing the creatinine-to-cystatin C ratio by the waist circumference in centimeters (cm) [22].…”

Section: Exposure Measurementmentioning

confidence: 99%

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Serum-Creatinine-to-Cystatin C-to-Waist-Circumference Ratios as an Indicator of Severe Airflow Limitation in Older Adults

Li,

Sun,

Zhang

et al. 2023

JCM

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Background: This study aimed to investigate the association between the serum-creatinine-to-cystatin C-to-waist-circumference (CCR/WC) ratio with lung function and severe airflow limitation (SAL). Methods: The data were derived from the China Health and Retirement Longitudinal Study. Peak expiratory flow (PEF) was used as a measure of lung function parameter. Logistic and linear regression were utilized separately to evaluate the relationship between the CCR/WC ratio with PEF and SAL in baseline. Restricted cubic spline was used to explore potential non-linear associations between the CCR/WC ratio and SAL. Cox proportional-hazards models were used to assess the association between CCR/WC quartiles and the risk of new-onset SAL. Results: A total of 6105 participants were included. This study revealed a positive association between the CCR/WC ratio and lung function (PEF: β [partial coefficient]: 25.95, 95%CI: 12.72 to 39.18, p < 0.001; PEF/PEF prediction: β = 0.08, 95%CI: 0.05 to 0.12, p < 0.001) and an inverse association relationship with SAL (OR [odds ratio]: 0.64, 95% confidence interval [CI]: 0.47 to 0.85, p = 0.003). Subgroup analysis showed a significant association between the CCR/WC ratio and SAL in males (OR: 0.58, 95% CI: 0.37 to 0.90, p = 0.017) but not in females (p = 0.059). Cox regression analysis revealed a decreased risk of SAL in the quartiles (Q2–4) compared to the first quartile of the CCR/WC ratio (hazard ratios [HRs]: 0.49 to 0.73, all p < 0.05). Conclusions: This study highlights a positive association between the CCR/WC ratio and lung function, with a potential protective effect against SAL.

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“…The procedure for measuring WC involved placing a measuring tape horizontally at the level of the participant’s waist, aligned with the navel, while the participant stood still, maintained calm breathing, and held their breath at the end of exhalation. The CCR was determined by dividing the creatinine value (mg/dL) by the cystatin C value (mg/L) and multiplying the result by 100, and the CCR/WC was calculated by dividing the CCR by the WC in centimeters ( 27 ). The ratio of CCR/WC was obtained at baseline in 2011.…”

Section: Methodsmentioning

confidence: 99%

Association of serum creatinine to cystatin C to waist circumference ratios and hypertension: evidence from China health and retirement longitudinal study

Yang,

Sun,

et al. 2024

Front. Endocrinol.

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BackgroundThe objective of this study was to explore the association between the ratio of serum creatinine to cystatin C to waist circumference (CCR/WC) and hypertension.MethodsThe study utilized data extracted from the China Health and Retirement Longitudinal Study. In the cross-sectional analysis, logistic regression analyses were employed to examine the association between the CCR/WC ratio and hypertension. By utilizing restricted cubic splines, potential non-linear associations between the CCR/WC ratio and hypertension were explored. In the longitudinal analysis, the association between CCR/WC quartiles (Q1–Q4) and the risk of new-onset hypertension was evaluated by Cox proportional-hazards models.ResultsIn total, 7,253 participants were enrolled. The study unveiled an inverse association with hypertension, demonstrating an odds ratio (OR) of 0.29 (95% confidence interval [CI]: 0.23–0.37, P < 0.001). Among males, an OR of 0.38 (95% CI: 0.25–0.58, P < 0.001) was observed, while among females, an OR of 0.41 (95% CI: 0.28–0.60, P < 0.001) was noted. There was an absence of a nonlinear association between the CCR/WC ratio and hypertension. Cox regression analysis unveiled a reduced risk of hypertension in Q3 (Hazard ratios [HR]: 0.69, 95% CI: 0.58–0.82, P < 0.001) and Q4: (HR: 0.70, 95% CI: 0.59–0.83, P < 0.001) in compared to the Q1 of the CCR/WC ratio, and sex-specific analysis yielded consistent results.ConclusionThis study emphasizes the potential association between an elevated CCR/WC ratio and a reduced risk of hypertension.

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The serum creatinine to cystatin C to waist circumference ratios predicts risk for type 2 diabetes: A Chinese cohort study

Cited by 3 publications

References 46 publications

Muscle-origin creatinine-cystatin C ratio is an osteoporosis marker in individuals with normal renal function: evidence from observational and Mendelian randomization analysis

Muscle-origin creatinine-cystatin C ratio is an osteoporosis marker in individuals with normal renal function: evidence from observational and Mendelian randomization analysis

Serum-Creatinine-to-Cystatin C-to-Waist-Circumference Ratios as an Indicator of Severe Airflow Limitation in Older Adults

Association of serum creatinine to cystatin C to waist circumference ratios and hypertension: evidence from China health and retirement longitudinal study

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