The serum leptin level in non-obese patients with obstructive sleep apnea

Pamuk, Ahmet Erim; Süslü, Ahmet Emre; Yalçınkaya, Ahmet; Öztaş, Yeşim; Pamuk, Gözde; Özer, Serdar; Önerci, Metin

doi:10.1016/j.anl.2017.11.009

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…Pamuk et al. ( 71 ) reported that serum leptin levels of non-obese individuals and non-obese patients with mild OSA are not significantly different and suggested that obesity is an important factor affecting serum leptin levels. A study on the role of leptin in children with OSA found no significant difference in leptin levels between OSA and non-OSA groups, and after correction for obesity factors, the correlation between leptin and oxygen desaturation index was eliminated ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

2021

Front. Endocrinol.

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BackgroundObstructive sleep apnea syndrome (OSAS) is associated with various adipokines. Leptin, a common adipokine, has attracted considerable attention of many researchers in recent years. So far, there has been little agreement on whether blood leptin levels differ in patients with OSAS. Thus, this meta-analysis examined the relationship between serum/plasma leptin levels and the occurrence of OSAS.MethodWanFang, Embase, CNKI, Medline, SinoMed, Web of Science, and PubMed were searched for articles before March 30, 2021, with no language limitations. STATA version 11.0 and R software version 3.6.1 were used to analyze the obtained data. The weighted mean difference and correlation coefficients were used as the main effect sizes with a random-effects model and a fixed-effects model, respectively. Trial sequential analysis was conducted using dedicated software.ResultScreening of 34 publications identified 45 studies that met the inclusion criteria of this meta-analysis and meta-regression. Our results suggested that plasma/serum leptin levels were remarkably higher in individuals with OSAS than in healthy individuals. Subgroup analyses were performed based on OSAS severity, ethnicity, age, body mass index, assay type, and sample source. The serum and plasma leptin levels were increased in nearly all OSAS subgroups compared to those in the corresponding control groups. Meta-regression analysis indicated that age, BMI, severity, assay approaches, study design, PSG type and ethnicity did not have independent effect on leptin levels. Furthermore, a positive relationship between the serum/plasma leptin level and apnea-hypopnea index (AHI) was found in the meta-analysis. The results of the trial sequential analysis suggested that the enrolled studies surpassed the required information size, confirming that our study findings were reliable.ConclusionOur study results demonstrate that OSAS patients have higher leptin levels in serum/plasma compared to controls, and the serum/plasma leptin level is positively correlated with AHI, especially in adults.

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Section: Discussionmentioning

confidence: 99%

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

2021

Front. Endocrinol.

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“…There are also studies that believe that an increased percentage of rapid eye movement sleep was related to a greater reduction in LP during sleep even when controlling for age, gender, percent body fat and total sleep time, no significant relationship was observed between non-REM sleep stages and overnight change in LP levels ( 30 ). However, a study involving 73 non-obese OSAHS patients revealed that serum LP levels did not exert any influence on PSG parameters ( 31 ). The discrepancy in findings may be attributed to the fact that this research encompasses the LP levels of all BMI populations, rather than solely focusing on non-obese OSAHS patients.…”

Section: Discussionmentioning

confidence: 99%

“…According to reports, LP increased of delta power posited that an elevated level of LP stimulates the peripheral chemical reflex of hypoxia and facilitates the growth of sympathetic nerve in adipose tissue (29). There are also studies that believe that an increased percentage of rapid eye movement sleep was related to a greater reduction in LP during sleep even when controlling for age, gender, percent body fat and total sleep time, no significant relationship was observed between non-REM sleep stages and overnight change in LP levels (30). However, a study involving 73 non-obese OSAHS patients revealed that serum LP levels did not exert any influence on PSG parameters (31).…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum leptin level and sleep monitoring indexes in patients with obstructive sleep apnea hypopnea syndrome and its predictive value: a cross-sectional analysis

Li,

Zhou,

Chen

et al. 2024

Front. Med.

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ObjectiveTo investigate the association between serum leptin (LP) level and polysomnography (PSG) parameters in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).MethodsA cross-sectional study was conducted. The data of subjects who underwent PSG at hospital between January 2021 and December 2022 were collected retrospectively, 220 participants were included. The subjects were categorized into simple snoring group (n = 45), mild OSAHS group (n = 63), moderate OSAHS group (n = 52), and severe OSAHS group (n = 60). The general characteristics, PSG indices, and serological indices were collected retrospectively. Pearson correlation analysis was used to observe the correlation between serum LP level and PSG parameters. The value of serum LP level in predicting OSAHS was analyzed by receiver operating characteristic curve.ResultsThe serum LP level was positively correlated with micro-arousal count, micro-arousal index (MAI), high apnea hypopnea index, times of blood oxygen decreased by≥3% and time in saturation lower 90%, and negatively correlated with lowest nocturnal oxygen saturation and mean oxygen saturation (p < 0.05). The area under the curve (AUC) of serum LP level in predicting the occurrence of OSAHS was 0.8276 (95% CI: 0.7713–0.8839), and when the Youden index was 0.587, the sensitivity was 72.00%, and the specificity was 86.67% (p < 0.0001). In the population with high MAI, the AUC of serum LP level in predicting the occurrence of OSAHS was 0.8825 (95% CI: 0.7833–0.9817), and when the Youden index was 0.690, the sensitivity was 79.00% and the specificity was 90.00% (p < 0.0001).ConclusionSerum LP level is associated with the severity of OSAHS. Serum LP level demonstrates a strong predictive value for the occurrence of OSAHS, particularly in population with high MAI.

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“…Leptin concentrations are positively correlated with obesity [ 1 ]. Leptin serum levels are increased in OSA syndrome patients, mostly because of obesity [ 112 , 134 , 135 , 136 ], and, in some studies, it correlated with the severity of this syndrome [ 137 ]. Moreover, poor sleep quality in overweight and obese subjects without OSA was associated with increased levels of leptin [ 138 ].…”

Section: The Association Of Adipokines With Sleep Disorders and Cancermentioning

confidence: 99%

The Modulation of Adipokines, Adipomyokines, and Sleep Disorders on Carcinogenesis

Brzecka

Martynowicz

Daroszewski

et al. 2023

JCM

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Obesity and sarcopenia, i.e., decreased skeletal muscle mass and function, are global health challenges. Moreover, people with obesity and sedentary lifestyles often have sleep disorders. Despite the potential associations, metabolic disturbances linking obesity, sarcopenia, and sleep disorders with cancer are neither well-defined nor understood fully. Abnormal levels of adipokines and adipomyokines originating from both adipose tissue and skeletal muscles are observed in some patients with obesity, sarcopenia and sleep disorders, as well as in cancer patients. This warrants investigation with respect to carcinogenesis. Adipokines and adipomyokines may exert either pro-carcinogenic or anti-carcinogenic effects. These factors, acting independently or together, may significantly modulate the incidence and progression of cancer. This review indicates that one of the possible pathways influencing the development of cancer may be the mutual relationship between obesity and/or sarcopenia, sleep quantity and quality, and adipokines/adipomyokines excretion. Taking into account the high proportion of persons with obesity and sedentary lifestyles, as well as the associations of these conditions with sleep disturbances, more attention should be paid to the individual and combined effects on cancer pathophysiology.

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The serum leptin level in non-obese patients with obstructive sleep apnea

Cited by 8 publications

References 19 publications

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Correlation between serum leptin level and sleep monitoring indexes in patients with obstructive sleep apnea hypopnea syndrome and its predictive value: a cross-sectional analysis

The Modulation of Adipokines, Adipomyokines, and Sleep Disorders on Carcinogenesis

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