The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer

Haraguchi, Masashi; Fujita, Fumihiko; Torashima, Yasuhiro; Inokuma, Takamitsu; Tajima, Yoshitsugu; Kanematsu, Takashi

doi:10.1007/s00595-009-4205-4

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…According to the results of this study, which developed a machine learning-based prognosis prediction model for breast cancer patients, the sensitivity of tumor markers was higher than that of previous studies using tumor marker information collected during follow-up period before breast cancer surgery, and the specificity was slightly lower [37]. In addition, the AUC values in our study were higher than in previous studies that analyzed the correlation between tumor markers and prognostic factors in colorectal cancer patients [43].…”

Section: Journal Of Health Informatics and Statisticscontrasting

confidence: 70%

“…According to the results of previous studies using student t-test and Kruskal-Wallis test to confirm the correlation between CEA and CA15-3, TPA tumor markers and prognostic factors and metastasis, the serum levels of CA15-3 and TPA appears to have a significant relation to the distant metastasis in breast cancer patients [37]. In addition, there was a statistically significant difference between the positive number of lymph node metastasis and tumor markers such as CEA and CA15-3 [38] The sensitivity and specificity of CEA were higher than those in the study of metastasis prediction in liver patients (73.4% and 30%, respectively) [43]. However, the specificity of CEA was only 40% in the prediction of metastasis or local recurrence, and thus its clinical application is limited [10].…”

Section: Journal Of Health Informatics and Statisticsmentioning

confidence: 99%

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Development of Breast Cancer Prognosis Prediction Model Based on Clinical Features Including CEA and CA15-3 Serum Levels

Yang¹,

Kwon²,

Lee³

et al. 2022

J Health Info Stat

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Objectives: Serum levels of carcinoembryonic antigen and cancer antigen 15-3 tumor markers are used for breast cancer prognosis. This study developed a breast cancer prognosis prediction model.Methods: We retrospectively analyzed data of 639 patients diagnosed between January 2012 and December 2019. We selected 20 independent variables with carcinoembryonic antigen and cancer antigen 15-3 serum levels and employed four machine-learning algorithms for the model: artificial neural network, random forest, support vector machine, and logistic regression.Results: Significant differences in carcinoembryonic antigen and cancer antigen 15-3 serum levels, age, history of other diseases excluding hypertension and diabetes mellitus, chemotherapy, and drug therapy were noted between control (n = 576) and case groups (n = 63). The sensitivity and specificity of the artificial neural network model for prognosis prediction were 26.7% and 92.6%, respectively.Conclusions: Carcinoembryonic antigen and cancer antigen 15-3 serum levels were the most significant variables for developing a breast cancer prognosis prediction model using the Shapley additive explanations model. The proposed machine-learning model and tumor marker serum levels may be useful for breast cancer prognosis.

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Section: Journal Of Health Informatics and Statisticscontrasting

confidence: 70%

Section: Journal Of Health Informatics and Statisticsmentioning

confidence: 99%

Development of Breast Cancer Prognosis Prediction Model Based on Clinical Features Including CEA and CA15-3 Serum Levels

Yang¹,

Kwon²,

Lee³

et al. 2022

J Health Info Stat

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“…Usually, increased CEA levels could be used for individual risk assessments and predicting metachronous metastases or poor overall survival. 24 – 26 We found that patients with high preoperative CEA levels were more likely to develop MAN (OR, 2.58). These findings suggest that high blood CEA levels may be a useful indicator of MAN.…”

Section: Discussionmentioning

confidence: 82%

<p>Risk Stratification Based on Synchronous Neoplasia and Clinical Physicochemical Characteristics Predicts a Higher Incidence of Metachronous Advanced Neoplasia in Patients Undergoing Colorectal Resection for Colorectal Cancer</p>

Yan¹,

Yu²,

Li³

2020

CMAR

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Purpose Patients who undergo primary colorectal cancer (CRC) resection remain at increased risk for metachronous advanced neoplasia (MAN) in the remnant colorectum. This study aimed to investigate the incidence and clinicopathological characteristics predictive of MAN development in the residual colon after surgery. Patients and Methods We retrospectively reviewed 450 primary CRC cases referred to our hospital during a 4-year period. Univariate and multivariate analyses were performed to identify risk factors for MAN. The cumulative incidence of MAN was evaluated by the Cox proportional hazards model. Results MAN development was confirmed in 78 of the 450 patients (17.3%). Overall 1-, 2-, 3-, and 5-year cumulative probabilities were 0.9%, 4.8%, 9.8%, and 16.1%, respectively, for MAN. Among the clinical and colonoscopic factors at baseline, the independent factors that were significantly associated with MAN were synchronous neoplasia, carcinoembryonic antigen (CEA) level ≥10.0 ng/mL, and index cancer size ≥50 mm. The cumulative probability of MAN was significantly higher for patients with synchronous advanced neoplasia (SAN) than for those without synchronous neoplasia (P = 0.000). A subgroup analysis of patients based on the CEA level and index cancer size indicated that CEA ≥10 ng/mL and index cancer ≥50 mm resulted in a significantly higher cumulative probability of MAN (P = 0.039). Conclusion Patients with SAN or high preoperative serum CEA levels and large index cancer are at increased risk for early-onset MAN. More intensive surveillance strategies may be appropriate for these groups. Risk stratification based on synchronous neoplasia and clinical physicochemical characteristics requires further investigations involving modified appropriate postoperative colonoscopic surveillance schedules.

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Circulating Antibodies to Carcinoembryonic Antigen Related to Improved Recurrence-Free Survival of Patients with Colorectal Carcinoma

Fang

Lin

et al. 2011

J Int Med Res

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The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer

Abstract: There was virtually no change between preoperative p-CEA and d-CEA levels. These findings suggest that the d-CEA level is not a predictor for metachronous hepatic metastasis and that measuring p-CEA levels is sufficient in the surveillance of colorectal cancer.

Cited by 3 publications

References 30 publications

Development of Breast Cancer Prognosis Prediction Model Based on Clinical Features Including CEA and CA15-3 Serum Levels

Development of Breast Cancer Prognosis Prediction Model Based on Clinical Features Including CEA and CA15-3 Serum Levels

<p>Risk Stratification Based on Synchronous Neoplasia and Clinical Physicochemical Characteristics Predicts a Higher Incidence of Metachronous Advanced Neoplasia in Patients Undergoing Colorectal Resection for Colorectal Cancer</p>

Circulating Antibodies to Carcinoembryonic Antigen Related to Improved Recurrence-Free Survival of Patients with Colorectal Carcinoma

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