The serum pepsinogen level with special reference to the histology of the gastric mucosa

Estimation of serum pepsinogen.

“…Smaller degrees of overlap were found by Bock et al (1963), Nolan (1958, and Singh and Shinton (1965). We are not aware of any reports of clear separation between the results from these two groups of subjects.…”

“…Patients with pernicious anaemia and related conditions show lower levels of serum pepsinogen than normal subjects (Chinn, 1953;Hoar and Browning, 1956;Mirsky, Futterman, and Kaplan, 1952;Nolan, 1958;Singh and Shinton, 1965). Bock, Arapakis, Witts, and Richards (1963), using a modification of the method of Edwards, Jepson, and Wood (1960) with freeze-dried human plasma as the substrate, found a correlation between the serum pepsinogen level and the histological appearance of gastric biopsy specimens.…”

“…A study of the method used by Bock et al (1963) showed it to be both too laborious and unsuitable in other respects for use in a survey requiring several hundred estimations. A modified method has therefore been developed, using haemoglobin as substrate, and incorporating a buffer system to control the pH of the mixtures of substrate and serum.…”

Studies on Uropepsin Excretion, Maximal and Basal Acid Output in Recurrent Peptic Ulcer

“…The explanation is presumably th at the pep sin and acid production does not occur in exactly the same parts of the stomach and th at the partial gastrectom y removes relatively more tissue which is mainly acid-producing than pepsinogen-producing tissue, as the concentration of parietal cells decreases towards the fundus. As the extent of the gastrectom y differs from patient to patient, the resected patients will show a considerably lower degree of covariance between uropepsin and PAO than unoperated patients, even when disregarding a possible gastritis-conditioned alteration in the ratio between acid and pepsinogen production (Bock et al 1963). Thus, although high uropepsin values as well as high PAO values indicate insufficient gastric resection, the present investigations appear to show th at the two tests supplement each other.…”

‘Latent’ Pernicious Anaemia in Delhi (India)

“…Previous workers have examined the relationship between serum or plasma levels of pepsinogen and the status of parietal and peptic cell mass of the stomach, and have shown low levels of pepsinogen in pres ence of gastric atrophy [2,13,17]. Singh and Shinton [18] have re ported the usefulness of the measurement of this parameter in the diag nosis of pernicious anaemia.…”